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Tmc3 transmembrane channel-like gene family 3 [ Mus musculus (house mouse) ]

Gene ID: 233424, updated on 5-Mar-2024

Summary

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Official Symbol
Tmc3provided by MGI
Official Full Name
transmembrane channel-like gene family 3provided by MGI
Primary source
MGI:MGI:2669033
See related
Ensembl:ENSMUSG00000038540 AllianceGenome:MGI:2669033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030203A06
Summary
Predicted to enable mechanosensitive ion channel activity. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in bone and rib. Orthologous to human TMC3 (transmembrane channel like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 1.4), cerebellum adult (RPKM 1.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D3; 7 47.43 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83234112..83276060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (83584904..83626852)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19407 Neighboring gene STARR-positive B cell enhancer mm9_chr7:90574679-90574980 Neighboring gene retinoblastoma binding protein 6 pseudogene Neighboring gene predicted gene 10610 Neighboring gene STARR-seq mESC enhancer starr_19409 Neighboring gene predicted gene, 16638 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:90803780-90804044 Neighboring gene StAR related lipid transfer domain containing 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:90809590-90809791 Neighboring gene interleukin 16 Neighboring gene STARR-positive B cell enhancer ABC_E8840 Neighboring gene 3-phosphoglycerate dehydrogenase, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants. Beurg M, et al. J Gen Physiol, 2014 Jul. PMID 24981230, Free PMC Article
  2. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
  3. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane channel-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177695.4 → NP_808363.3  transmembrane channel-like protein 3

    See identical proteins and their annotated locations for NP_808363.3

    Status: VALIDATED

    Source sequence(s)
    AC158576, AY236491, AY263157
    Consensus CDS
    CCDS40012.1
    UniProtKB/Swiss-Prot
    Q7TN63, Q7TQ69
    UniProtKB/TrEMBL
    F8VQI4
    Related
    ENSMUSP00000046028.8, ENSMUST00000039317.14
    Conserved Domains (1) summary
    pfam07810
    Location:505 → 611
    TMC; TMC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    83234112..83276060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507591.3 → XP_006507654.1  transmembrane channel-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q7TN63, Q7TQ69
    UniProtKB/TrEMBL
    E9Q6Y0
    Related
    ENSMUSP00000130348.2, ENSMUST00000164944.2
    Conserved Domains (1) summary
    pfam07810
    Location:500 → 615
    TMC; TMC domain

RNA

  1. XR_001785530.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQ69.1 GenPept UniProtKB/Swiss-Prot:Q7TQ69

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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