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Zfp592 zinc finger protein 592 [ Mus musculus (house mouse) ]

Gene ID: 233410, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp592provided by MGI
Official Full Name
zinc finger protein 592provided by MGI
Primary source
MGI:MGI:2443541
See related
Ensembl:ENSMUSG00000005621 AllianceGenome:MGI:2443541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf592; A730014M16Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; and neural ectoderm. Orthologous to human ZNF592 (zinc finger protein 592). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.4), spleen adult (RPKM 11.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D3; 7 45.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80643432..80694912)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80993684..81045162)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51451 Neighboring gene SEC11 homolog A, signal peptidase complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E2829 Neighboring gene STARR-seq mESC enhancer starr_19348 Neighboring gene predicted gene, 32178 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene STARR-seq mESC enhancer starr_19350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88220222-88220409 Neighboring gene alpha-kinase 3 Neighboring gene predicted gene, 51490 Neighboring gene solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 Neighboring gene STARR-seq mESC enhancer starr_19353 Neighboring gene STARR-positive B cell enhancer mm9_chr7:88299922-88300223 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IRS pleckstrin homology domains bind to acidic motifs in proteins. Burks DJ, et al. J Biol Chem, 1998 Nov 20. PMID 9813005
  2. CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592. Nicolas E, et al. Eur J Hum Genet, 2010 Oct. PMID 20531441, Free PMC Article
  3. DNMT1 interacts with the developmental transcriptional repressor HESX1. Sajedi E, et al. Biochim Biophys Acta, 2008 Jan. PMID 17931718, Free PMC Article
  4. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
  5. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0211, 8430405N24

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables PH domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 592

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178707.4 → NP_848822.2  zinc finger protein 592

    See identical proteins and their annotated locations for NP_848822.2

    Status: VALIDATED

    Source sequence(s)
    AK033364, AK042675, BC094321
    Consensus CDS
    CCDS40003.2
    UniProtKB/Swiss-Prot
    Q80XM1, Q8BHZ4
    UniProtKB/TrEMBL
    Q3UPC8
    Related
    ENSMUSP00000102976.3, ENSMUST00000107353.3
    Conserved Domains (2) summary
    sd00017
    Location:985 → 1005
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam16622
    Location:1149 → 1177
    zf-C2H2_11; zinc-finger C2H2-type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80643432..80694912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152983.1 → XP_036008876.1  zinc finger protein 592 isoform X1

    UniProtKB/TrEMBL
    Q3UPC8
    Conserved Domains (3) summary
    PTZ00449
    Location:261 → 470
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    sd00017
    Location:994 → 1014
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam16622
    Location:1158 → 1186
    zf-C2H2_11; zinc-finger C2H2-type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHZ4.3 GenPept UniProtKB/Swiss-Prot:Q8BHZ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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