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Scaf1 SR-related CTD-associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 233208, updated on 5-Mar-2024

Summary

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Official Symbol
Scaf1provided by MGI
Official Full Name
SR-related CTD-associated factor 1provided by MGI
Primary source
MGI:MGI:2141980
See related
Ensembl:ENSMUSG00000038406 AllianceGenome:MGI:2141980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SR-A1
Summary
Predicted to enable RNA polymerase II C-terminal domain binding activity and protein domain specific binding activity. Predicted to be involved in mRNA processing and transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing. Predicted to be located in nucleus. Orthologous to human SCAF1 (SR-related CTD associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 47.0), ovary adult (RPKM 42.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 29.07 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44652372..44665537, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45002946..45016404, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15545 Neighboring gene BCL2 like 12 Neighboring gene interferon regulatory factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E130 Neighboring gene microRNA 7054 Neighboring gene STARR-positive B cell enhancer ABC_E871 Neighboring gene related RAS viral (r-ras) oncogene Neighboring gene proline rich 12 Neighboring gene STARR-positive B cell enhancer ABC_E6541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Malondialdehyde-acetaldehyde (MAA) adducted surfactant protein induced lung inflammation is mediated through scavenger receptor a (SR-A1). Sapkota M, et al. Respir Res, 2017 Feb 13. PMID 28193223, Free PMC Article
  2. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overall, the data demonstrate that SR-A1/CD204 plays an important role in SPD-MAA induced inflammation in lung.
    Title: Malondialdehyde-acetaldehyde (MAA) adducted surfactant protein induced lung inflammation is mediated through scavenger receptor a (SR-A1).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109685

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II C-terminal domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II C-terminal domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
splicing factor, arginine/serine-rich 19
Names
SR-related and CTD-associated factor 1
serine arginine-rich pre-mRNA splicing factor SR-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008422.2 → NP_001008422.1  splicing factor, arginine/serine-rich 19 isoform 1

    See identical proteins and their annotated locations for NP_001008422.1

    Status: VALIDATED

    Source sequence(s)
    AC126256
    Consensus CDS
    CCDS21225.1
    UniProtKB/Swiss-Prot
    Q3UR01, Q5U4C3
    Related
    ENSMUSP00000082501.3, ENSMUST00000085383.11

  2. NM_001400819.1 → NP_001387748.1  splicing factor, arginine/serine-rich 19 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126256
    UniProtKB/Swiss-Prot
    Q3UR01, Q5U4C3
    Related
    ENSMUSP00000148251.2, ENSMUST00000211735.2

  3. NM_001400820.1 → NP_001387749.1  splicing factor, arginine/serine-rich 19 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126256
    UniProtKB/Swiss-Prot
    Q3UR01, Q5U4C3

  4. NM_001400821.1 → NP_001387750.1  splicing factor, arginine/serine-rich 19 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126256
    UniProtKB/Swiss-Prot
    Q3UR01, Q5U4C3

  5. NM_001400822.1 → NP_001387751.1  splicing factor, arginine/serine-rich 19 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126256
    Related
    ENSMUST00000210056.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44652372..44665537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003946455.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4C3.1 GenPept UniProtKB/Swiss-Prot:Q5U4C3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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