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Siglecf sialic acid binding Ig-like lectin F [ Mus musculus (house mouse) ]

Gene ID: 233186, updated on 11-Apr-2024

Summary

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Official Symbol
Siglecfprovided by MGI
Official Full Name
sialic acid binding Ig-like lectin Fprovided by MGI
Primary source
MGI:MGI:2681107
See related
Ensembl:ENSMUSG00000039013 AllianceGenome:MGI:2681107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siglec5; mSiglec-F
Summary
Enables monosaccharide binding activity and sialic acid binding activity. Involved in regulation of endocytosis. Located in lysosome. Orthologous to several human genes including SIGLEC6 (sialic acid binding Ig like lectin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 6.0), small intestine adult (RPKM 1.8) and 11 other tissues See more
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Genomic context

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See Siglecf in Genome Data Viewer
Location:
7 B3; 7 28.25 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43000496..43008899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43351341..43359475)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35588 Neighboring gene STARR-seq mESC enhancer starr_18763 Neighboring gene zinc finger protein 715 Neighboring gene STARR-positive B cell enhancer ABC_E4922 Neighboring gene STARR-seq mESC enhancer starr_18769 Neighboring gene STARR-seq mESC enhancer starr_18772 Neighboring gene STARR-positive B cell enhancer mm9_chr7:50633698-50633999 Neighboring gene sialic acid binding Ig-like lectin G Neighboring gene predicted gene, 38999

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. Morshed N, et al. Mol Syst Biol, 2020 Dec. PMID 33289969, Free PMC Article
  2. A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model. Matsui M, et al. Biochem Biophys Res Commun, 2020 Jun 4. PMID 32247614
  3. Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls. Knuplez E, et al. J Leukoc Biol, 2020 Jul. PMID 32134149, Free PMC Article
  4. Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages. Tateyama H, et al. Immunology, 2019 Dec. PMID 31520477, Free PMC Article
  5. Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice. Wei Y, et al. Int J Mol Sci, 2018 Dec 21. PMID 30577572, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Induction of Siglec-F[hi]CD101[hi] eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
    Title: Induction of Siglec-F(hi)CD101(hi) eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
  2. Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.
    Title: Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.
  3. IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils.
    Title: IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils.
  4. Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
    Title: Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
  5. A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.
    Title: A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.
  6. the knockdown of Siglec-F enhanced GM-CSF-induced STAT5 phosphorylation and reduced the STAT6 phosphorylation and expression of arginase-1 in interleukin-4-stimulated macrophages
    Title: Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
  7. Immunohistochemical analysis of the Peyer's patches (PPs) tissue sections shows that Siglec-F is expressed on the surface of the Intestinal microfold (M) cell membrane exposed to the intestinal lumen.
    Title: Siglec-F is a novel intestinal M cell marker.
  8. These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F.
    Title: Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.
  9. depending on the nature of the allergy model used, the negative regulatory role of siglec-F on eosinophilia may be overridden.
    Title: Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.
  10. Engagement of Siglec-F induced mouse eosinophil apoptosis that was modest in magnitude and dependent on caspase activity.
    Title: Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables monosaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sialic acid-binding Ig-like lectin 5
Names
sialic acid-binding lectin Siglec-F
siglec-5
siglec-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271019.1 → NP_001257948.1  sialic acid-binding Ig-like lectin 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF293371, BB842394, BC145038
    Consensus CDS
    CCDS85278.1
    UniProtKB/TrEMBL
    B7ZN64, Q80ZE2
    Related
    ENSMUSP00000146009.2, ENSMUST00000206299.2
    Conserved Domains (2) summary
    smart00410
    Location:252 → 325
    IG_like; Immunoglobulin like
    cl11960
    Location:20 → 132
    Ig; Immunoglobulin domain

  2. NM_145581.2 → NP_663556.1  sialic acid-binding Ig-like lectin 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_663556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes a longer isoform (1).
    Source sequence(s)
    AF293371, BB842394
    Consensus CDS
    CCDS21167.1
    UniProtKB/Swiss-Prot
    Q920G3
    UniProtKB/TrEMBL
    Q80ZE2
    Related
    ENSMUSP00000012798.8, ENSMUST00000012798.14
    Conserved Domains (2) summary
    smart00410
    Location:252 → 325
    IG_like; Immunoglobulin like
    cl11960
    Location:20 → 132
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43000496..43008899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152965.1 → XP_036008858.1  sialic acid-binding Ig-like lectin 5 isoform X1

    UniProtKB/TrEMBL
    Q80ZE2
    Conserved Domains (3) summary
    smart00409
    Location:272 → 345
    IG; Immunoglobulin
    cd00096
    Location:40 → 44
    Ig; Ig strand A [structural motif]
    cl11960
    Location:40 → 153
    Ig; Immunoglobulin domain

  2. XM_036152966.1 → XP_036008859.1  sialic acid-binding Ig-like lectin 5 isoform X2

    UniProtKB/TrEMBL
    Q80ZE2
    Conserved Domains (3) summary
    smart00409
    Location:272 → 345
    IG; Immunoglobulin
    cd00096
    Location:40 → 44
    Ig; Ig strand A [structural motif]
    cl11960
    Location:40 → 153
    Ig; Immunoglobulin domain

  3. XM_006540816.1 → XP_006540879.1  sialic acid-binding Ig-like lectin 5 isoform X3

    See identical proteins and their annotated locations for XP_006540879.1

    UniProtKB/TrEMBL
    Q80ZE2
    Conserved Domains (2) summary
    smart00410
    Location:252 → 325
    IG_like; Immunoglobulin like
    cl11960
    Location:20 → 132
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920G3.1 GenPept UniProtKB/Swiss-Prot:Q920G3

Gene LinkOut

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