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TUT4 terminal uridylyl transferase 4 [ Homo sapiens (human) ]

Gene ID: 23318, updated on 7-Apr-2024

Summary

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Official Symbol
TUT4provided by HGNC
Official Full Name
terminal uridylyl transferase 4provided by HGNC
Primary source
HGNC:HGNC:28981
See related
Ensembl:ENSG00000134744 MIM:613692; AllianceGenome:HGNC:28981
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPD3; TENT3A; ZCCHC11
Summary
Enables RNA uridylyltransferase activity. Involved in RNA metabolic process; negative regulation of transposition, RNA-mediated; and stem cell population maintenance. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleolus. Implicated in liver benign neoplasm. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 11.1), thyroid (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p32.3
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52423275..52553463, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52304743..52434560, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52888947..53018764, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:52869594-52870793 Neighboring gene uncharacterized LOC124904850 Neighboring gene Sharpr-MPRA regulatory region 15542 Neighboring gene pre-mRNA processing factor 38A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1032 Neighboring gene MPRA-validated peak227 silencer Neighboring gene MPRA-validated peak228 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52963547-52964066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52964067-52964586 Neighboring gene uncharacterized LOC105378723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53036969-53037469 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 7 Neighboring gene glutathione peroxidase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinetic and Mechanistic Studies of the Terminal Uridylyltransferase, Zcchc11 (TUT4). Stein RL, et al. Biochemistry, 2022 Aug 2. PMID 35797480
  2. Identification of small molecule inhibitors of Zcchc11 TUTase activity. Lin S, et al. RNA Biol, 2015. PMID 26114892, Free PMC Article
  3. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity. Blahna MT, et al. J Biol Chem, 2011 Dec 9. PMID 22006926, Free PMC Article
  4. Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis. Zhang P, et al. Cells, 2022 Nov 23. PMID 36497000, Free PMC Article
  5. RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. Medhi R, et al. RNA, 2022 Mar. PMID 34949722, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
    Title: Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis.
  2. TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
    Title: TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
  3. RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
    Title: RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type.
  4. Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11.
    Title: Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11.
  5. This tail-U-mediated repression (TUMR) is abolished in cells lacking the uridylation enzymes TUT4 and TUT7, indicating that uridylation alters miRNA function by modulating target recognition. We identified a set of non-canonical targets in human cells that are specifically regulated by uridylated miR-27a.
    Title: 3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
  6. Uridylation by TUT4, which is enriched in cytoplasmic foci, destabilizes LINE-1 mRNAs.
    Title: Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.
  7. The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
    Title: Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
  8. For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s
    Title: Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.
  9. Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) activity.
    Title: Identification of small molecule inhibitors of Zcchc11 TUTase activity.
  10. Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
    Title: Uridylation by TUT4 and TUT7 marks mRNA for degradation.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42878, DKFZp779C1943

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA 3' uridylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in polyuridylation-dependent mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pre-miRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pre-miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
terminal uridylyltransferase 4
Names
PAP associated domain containing 3
TUTase 4
zinc finger CCHC domain-containing protein 11
zinc finger CCHC-type containing 11
zinc finger, CCHC domain containing 11
NP_001009881.1
NP_056084.1
XP_005270733.1
XP_005270735.1
XP_005270736.1
XP_005270737.1
XP_005270738.1
XP_005270739.1
XP_011539399.1
XP_011539401.1
XP_016856292.1
XP_016856293.1
XP_016856294.1
XP_016856295.1
XP_016856296.1
XP_016856297.1
XP_016856299.1
XP_016856307.1
XP_047272280.1
XP_047272281.1
XP_047272282.1
XP_047272283.1
XP_047272285.1
XP_047272286.1
XP_047272288.1
XP_047272290.1
XP_047272295.1
XP_047272296.1
XP_047272303.1
XP_047272305.1
XP_047272306.1
XP_047272307.1
XP_047272311.1
XP_047272320.1
XP_047272325.1
XP_047272327.1
XP_047272336.1
XP_047272337.1
XP_047272344.1
XP_047272345.1
XP_047272348.1
XP_047272350.1
XP_047272354.1
XP_047272362.1
XP_047272365.1
XP_047272367.1
XP_047272369.1
XP_047272372.1
XP_047272373.1
XP_047272377.1
XP_047272384.1
XP_054191485.1
XP_054191486.1
XP_054191487.1
XP_054191488.1
XP_054191489.1
XP_054191490.1
XP_054191491.1
XP_054191492.1
XP_054191493.1
XP_054191494.1
XP_054191495.1
XP_054191496.1
XP_054191497.1
XP_054191498.1
XP_054191499.1
XP_054191500.1
XP_054191501.1
XP_054191502.1
XP_054191503.1
XP_054191504.1
XP_054191505.1
XP_054191506.1
XP_054191507.1
XP_054191508.1
XP_054191509.1
XP_054191510.1
XP_054191511.1
XP_054191512.1
XP_054191513.1
XP_054191514.1
XP_054191515.1
XP_054191516.1
XP_054191517.1
XP_054191518.1
XP_054191519.1
XP_054191520.1
XP_054191521.1
XP_054191522.1
XP_054191523.1
XP_054191524.1
XP_054191525.1
XP_054191526.1
XP_054191527.1
XP_054191528.1
XP_054191529.1
XP_054191530.1
XP_054191531.1
XP_054191532.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009881.3 → NP_001009881.1  terminal uridylyltransferase 4 isoform a

    See identical proteins and their annotated locations for NP_001009881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK025698, AL138849, AL591167, BC131734, DA748708
    Consensus CDS
    CCDS30715.1
    UniProtKB/TrEMBL
    A0A0C4DFM7
    Related
    ENSP00000257177.4, ENST00000257177.9
    Conserved Domains (6) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:628 → 677
    PAP_assoc; Cid1 family poly A polymerase
    cl00325
    Location:97 → 199
    Ribosomal_L4; Ribosomal protein L4/L1 family
    cl25764
    Location:1395 → 1620
    PAT1; Topoisomerase II-associated protein PAT1
    cl26705
    Location:1280 → 1375
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
    cl27230
    Location:929 → 1261
    PAP_assoc; Cid1 family poly A polymerase

  2. NM_015269.2 → NP_056084.1  terminal uridylyltransferase 4 isoform b

    See identical proteins and their annotated locations for NP_056084.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of a coding exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC035820, D83776, DA748708, R60512
    Consensus CDS
    CCDS30716.1
    UniProtKB/Swiss-Prot
    A2RRP0, B7Z8J5, D3DQ35, Q12764, Q5TAX2, Q5TAX3, Q5TAX4, Q86XZ3
    Related
    ENSP00000360599.3, ENST00000371544.7
    Conserved Domains (4) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:1184 → 1237
    PAP_assoc; Cid1 family poly A polymerase
    pfam09786
    Location:1374 → 1515
    CytochromB561_N; Cytochrome B561, N terminal
    pfam14650
    Location:1422 → 1483
    FAM75; FAM75 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    52423275..52553463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000804.3 → XP_016856293.1  terminal uridylyltransferase 4 isoform X16

  2. XM_047416324.1 → XP_047272280.1  terminal uridylyltransferase 4 isoform X3

  3. XM_047416327.1 → XP_047272283.1  terminal uridylyltransferase 4 isoform X6

  4. XM_005270678.3 → XP_005270735.1  terminal uridylyltransferase 4 isoform X2

    Conserved Domains (5) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:1184 → 1237
    PAP_assoc; Cid1 family poly A polymerase
    pfam07223
    Location:1382 → 1649
    DUF1421; Protein of unknown function (DUF1421)
    pfam09786
    Location:1374 → 1515
    CytochromB561_N; Cytochrome B561, N terminal
    pfam14650
    Location:1422 → 1483
    FAM75; FAM75 family

  5. XM_047416326.1 → XP_047272282.1  terminal uridylyltransferase 4 isoform X5

    UniProtKB/Swiss-Prot
    A2RRP0, B7Z8J5, D3DQ35, Q12764, Q5TAX2, Q5TAX3, Q5TAX4, Q86XZ3

  6. XM_011541097.2 → XP_011539399.1  terminal uridylyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_011539399.1

    Conserved Domains (7) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    PTZ00368
    Location:1280 → 1375
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    PRK14907
    Location:97 → 199
    rplD; 50S ribosomal protein L4; Provisional
    PHA03247
    Location:1406 → 1592
    PHA03247; large tegument protein UL36; Provisional
    COG5260
    Location:929 → 1261
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    pfam03828
    Location:628 → 677
    PAP_assoc; Cid1 family poly A polymerase
    pfam19088
    Location:265 → 600
    TUTase; TUTase nucleotidyltransferase domain

  7. XM_047416325.1 → XP_047272281.1  terminal uridylyltransferase 4 isoform X4

    UniProtKB/TrEMBL
    A0A0C4DFM7

  8. XM_047416416.1 → XP_047272372.1  terminal uridylyltransferase 4 isoform X42

  9. XM_047416421.1 → XP_047272377.1  terminal uridylyltransferase 4 isoform X44

  10. XM_047416417.1 → XP_047272373.1  terminal uridylyltransferase 4 isoform X43

  11. XM_017000808.2 → XP_016856297.1  terminal uridylyltransferase 4 isoform X36

  12. XM_017000810.3 → XP_016856299.1  terminal uridylyltransferase 4 isoform X40

  13. XM_047416409.1 → XP_047272365.1  terminal uridylyltransferase 4 isoform X38

  14. XM_005270682.3 → XP_005270739.1  terminal uridylyltransferase 4 isoform X33

    Conserved Domains (6) summary
    cd05402
    Location:860 → 978
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    PTZ00368
    Location:1169 → 1264
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    pfam03828
    Location:1073 → 1126
    PAP_assoc; Cid1 family poly A polymerase
    pfam07223
    Location:1272 → 1539
    DUF1421; Protein of unknown function (DUF1421)
    pfam09786
    Location:1264 → 1405
    CytochromB561_N; Cytochrome B561, N terminal
    pfam14650
    Location:1312 → 1373
    FAM75; FAM75 family

  15. XM_047416413.1 → XP_047272369.1  terminal uridylyltransferase 4 isoform X41

  16. XM_047416389.1 → XP_047272345.1  terminal uridylyltransferase 4 isoform X31

  17. XM_011541099.2 → XP_011539401.1  terminal uridylyltransferase 4 isoform X29

    Conserved Domains (6) summary
    cd05402
    Location:873 → 991
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    PTZ00368
    Location:1182 → 1277
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    pfam03828
    Location:1086 → 1139
    PAP_assoc; Cid1 family poly A polymerase
    pfam07223
    Location:1285 → 1552
    DUF1421; Protein of unknown function (DUF1421)
    pfam09786
    Location:1277 → 1418
    CytochromB561_N; Cytochrome B561, N terminal
    pfam14650
    Location:1325 → 1386
    FAM75; FAM75 family

  18. XM_047416380.1 → XP_047272336.1  terminal uridylyltransferase 4 isoform X26

  19. XM_047416371.1 → XP_047272327.1  terminal uridylyltransferase 4 isoform X24

  20. XM_047416355.1 → XP_047272311.1  terminal uridylyltransferase 4 isoform X21

  21. XM_047416364.1 → XP_047272320.1  terminal uridylyltransferase 4 isoform X22

  22. XM_017000803.2 → XP_016856292.1  terminal uridylyltransferase 4 isoform X9

  23. XM_047416329.1 → XP_047272285.1  terminal uridylyltransferase 4 isoform X7

  24. XM_047416332.1 → XP_047272288.1  terminal uridylyltransferase 4 isoform X10

  25. XM_047416394.1 → XP_047272350.1  terminal uridylyltransferase 4 isoform X34

  26. XM_047416388.1 → XP_047272344.1  terminal uridylyltransferase 4 isoform X30

  27. XM_047416411.1 → XP_047272367.1  terminal uridylyltransferase 4 isoform X39

  28. XM_047416406.1 → XP_047272362.1  terminal uridylyltransferase 4 isoform X37

  29. XM_047416392.1 → XP_047272348.1  terminal uridylyltransferase 4 isoform X32

  30. XM_047416398.1 → XP_047272354.1  terminal uridylyltransferase 4 isoform X35

  31. XM_017000806.2 → XP_016856295.1  terminal uridylyltransferase 4 isoform X25

  32. XM_017000807.3 → XP_016856296.1  terminal uridylyltransferase 4 isoform X28

  33. XM_047416369.1 → XP_047272325.1  terminal uridylyltransferase 4 isoform X23

  34. XM_047416381.1 → XP_047272337.1  terminal uridylyltransferase 4 isoform X27

  35. XM_047416334.1 → XP_047272290.1  terminal uridylyltransferase 4 isoform X11

  36. XM_047416349.1 → XP_047272305.1  terminal uridylyltransferase 4 isoform X17

  37. XM_047416340.1 → XP_047272296.1  terminal uridylyltransferase 4 isoform X13

  38. XM_047416330.1 → XP_047272286.1  terminal uridylyltransferase 4 isoform X8

  39. XM_047416339.1 → XP_047272295.1  terminal uridylyltransferase 4 isoform X12

  40. XM_047416350.1 → XP_047272306.1  terminal uridylyltransferase 4 isoform X18

  41. XM_017000805.3 → XP_016856294.1  terminal uridylyltransferase 4 isoform X20

  42. XM_047416347.1 → XP_047272303.1  terminal uridylyltransferase 4 isoform X15

  43. XM_047416351.1 → XP_047272307.1  terminal uridylyltransferase 4 isoform X19

  44. XM_005270681.3 → XP_005270738.1  terminal uridylyltransferase 4 isoform X14

    Conserved Domains (6) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    PTZ00368
    Location:1242 → 1337
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    pfam03828
    Location:1146 → 1199
    PAP_assoc; Cid1 family poly A polymerase
    pfam07223
    Location:1345 → 1612
    DUF1421; Protein of unknown function (DUF1421)
    pfam09786
    Location:1337 → 1478
    CytochromB561_N; Cytochrome B561, N terminal
    pfam14650
    Location:1385 → 1446
    FAM75; FAM75 family

  45. XM_005270679.3 → XP_005270736.1  terminal uridylyltransferase 4 isoform X3

    Conserved Domains (6) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    PTZ00368
    Location:1280 → 1370
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    pfam03828
    Location:1184 → 1237
    PAP_assoc; Cid1 family poly A polymerase
    pfam07223
    Location:1378 → 1645
    DUF1421; Protein of unknown function (DUF1421)
    pfam09786
    Location:1370 → 1511
    CytochromB561_N; Cytochrome B561, N terminal
    pfam14650
    Location:1418 → 1479
    FAM75; FAM75 family

  46. XM_005270680.4 → XP_005270737.1  terminal uridylyltransferase 4 isoform X6

    See identical proteins and their annotated locations for XP_005270737.1

    Conserved Domains (5) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    PTZ00368
    Location:1280 → 1370
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    pfam03828
    Location:1184 → 1237
    PAP_assoc; Cid1 family poly A polymerase
    pfam09786
    Location:1370 → 1511
    CytochromB561_N; Cytochrome B561, N terminal
    pfam14650
    Location:1418 → 1479
    FAM75; FAM75 family

  47. XM_005270676.3 → XP_005270733.1  terminal uridylyltransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_005270733.1

    Conserved Domains (7) summary
    cd05402
    Location:971 → 1089
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    PTZ00368
    Location:1280 → 1375
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    PRK14907
    Location:97 → 199
    rplD; 50S ribosomal protein L4; Provisional
    PHA03247
    Location:1406 → 1592
    PHA03247; large tegument protein UL36; Provisional
    COG5260
    Location:929 → 1261
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
    pfam03828
    Location:628 → 677
    PAP_assoc; Cid1 family poly A polymerase
    pfam19088
    Location:265 → 600
    TUTase; TUTase nucleotidyltransferase domain

  48. XM_047416428.1 → XP_047272384.1  terminal uridylyltransferase 4 isoform X46

  49. XM_017000818.2 → XP_016856307.1  terminal uridylyltransferase 4 isoform X45

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    52304743..52434560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335554.1 → XP_054191529.1  terminal uridylyltransferase 4 isoform X44

  2. XM_054335553.1 → XP_054191528.1  terminal uridylyltransferase 4 isoform X43

  3. XM_054335551.1 → XP_054191526.1  terminal uridylyltransferase 4 isoform X40

  4. XM_054335549.1 → XP_054191524.1  terminal uridylyltransferase 4 isoform X38

  5. XM_054335548.1 → XP_054191523.1  terminal uridylyltransferase 4 isoform X52

  6. XM_054335537.1 → XP_054191512.1  terminal uridylyltransferase 4 isoform X26

  7. XM_054335535.1 → XP_054191510.1  terminal uridylyltransferase 4 isoform X24

  8. XM_054335533.1 → XP_054191508.1  terminal uridylyltransferase 4 isoform X22

  9. XM_054335525.1 → XP_054191500.1  terminal uridylyltransferase 4 isoform X16

  10. XM_054335520.1 → XP_054191495.1  terminal uridylyltransferase 4 isoform X48

  11. XM_054335518.1 → XP_054191493.1  terminal uridylyltransferase 4 isoform X10

  12. XM_054335550.1 → XP_054191525.1  terminal uridylyltransferase 4 isoform X39

  13. XM_054335547.1 → XP_054191522.1  terminal uridylyltransferase 4 isoform X37

  14. XM_054335545.1 → XP_054191520.1  terminal uridylyltransferase 4 isoform X35

  15. XM_054335540.1 → XP_054191515.1  terminal uridylyltransferase 4 isoform X28

  16. XM_054335539.1 → XP_054191514.1  terminal uridylyltransferase 4 isoform X27

  17. XM_054335538.1 → XP_054191513.1  terminal uridylyltransferase 4 isoform X51

  18. XM_054335526.1 → XP_054191501.1  terminal uridylyltransferase 4 isoform X17

  19. XM_054335522.1 → XP_054191497.1  terminal uridylyltransferase 4 isoform X13

  20. XM_054335521.1 → XP_054191496.1  terminal uridylyltransferase 4 isoform X12

  21. XM_054335530.1 → XP_054191505.1  terminal uridylyltransferase 4 isoform X20

  22. XM_054335529.1 → XP_054191504.1  terminal uridylyltransferase 4 isoform X19

  23. XM_054335528.1 → XP_054191503.1  terminal uridylyltransferase 4 isoform X49

  24. XM_054335513.1 → XP_054191488.1  terminal uridylyltransferase 4 isoform X6

  25. XM_054335546.1 → XP_054191521.1  terminal uridylyltransferase 4 isoform X36

  26. XM_054335544.1 → XP_054191519.1  terminal uridylyltransferase 4 isoform X33

  27. XM_054335552.1 → XP_054191527.1  terminal uridylyltransferase 4 isoform X41

  28. XM_054335542.1 → XP_054191517.1  terminal uridylyltransferase 4 isoform X31

  29. XM_054335541.1 → XP_054191516.1  terminal uridylyltransferase 4 isoform X29

  30. XM_054335531.1 → XP_054191506.1  terminal uridylyltransferase 4 isoform X21

  31. XM_054335517.1 → XP_054191492.1  terminal uridylyltransferase 4 isoform X9

  32. XM_054335515.1 → XP_054191490.1  terminal uridylyltransferase 4 isoform X7

  33. XM_054335514.1 → XP_054191489.1  terminal uridylyltransferase 4 isoform X47

  34. XM_054335543.1 → XP_054191518.1  terminal uridylyltransferase 4 isoform X32

  35. XM_054335536.1 → XP_054191511.1  terminal uridylyltransferase 4 isoform X25

  36. XM_054335534.1 → XP_054191509.1  terminal uridylyltransferase 4 isoform X23

  37. XM_054335532.1 → XP_054191507.1  terminal uridylyltransferase 4 isoform X50

  38. XM_054335519.1 → XP_054191494.1  terminal uridylyltransferase 4 isoform X11

  39. XM_054335516.1 → XP_054191491.1  terminal uridylyltransferase 4 isoform X8

  40. XM_054335527.1 → XP_054191502.1  terminal uridylyltransferase 4 isoform X18

  41. XM_054335524.1 → XP_054191499.1  terminal uridylyltransferase 4 isoform X15

  42. XM_054335523.1 → XP_054191498.1  terminal uridylyltransferase 4 isoform X14

  43. XM_054335512.1 → XP_054191487.1  terminal uridylyltransferase 4 isoform X3

  44. XM_054335511.1 → XP_054191486.1  terminal uridylyltransferase 4 isoform X2

  45. XM_054335510.1 → XP_054191485.1  terminal uridylyltransferase 4 isoform X1

  46. XM_054335557.1 → XP_054191532.1  terminal uridylyltransferase 4 isoform X46

  47. XM_054335556.1 → XP_054191531.1  terminal uridylyltransferase 4 isoform X45

  48. XM_054335555.1 → XP_054191530.1  terminal uridylyltransferase 4 isoform X53

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009882.1: Suppressed sequence

    Description
    NM_001009882.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TAX3.3 GenPept UniProtKB/Swiss-Prot:Q5TAX3

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