Dpy19l3 dpy-19 like C-mannosyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpy19l3provided by MGI
Official Full Name: dpy-19 like C-mannosyltransferase 3provided by MGI
Primary source: MGI:MGI:2443952
See related: Ensembl:ENSMUSG00000043671 AllianceGenome:MGI:2443952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6030410G08; 9330164H19Rik
Summary: Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear inner membrane. Is expressed in cerebral cortex. Orthologous to human DPY19L3 (dpy-19 like C-mannosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 5.0), CNS E14 (RPKM 4.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 21.37 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (35384925..35453879, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (35685500..35754460, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of DPY19L3 in Myogenic Differentiation of C2C12 Myoblasts.
Title: Involvement of DPY19L3 in Myogenic Differentiation of C2C12 Myoblasts.
Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions.
Title: Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mannosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable C-mannosyltransferase DPY19L3

Names: dpy-19-like 3; dpy-19-like protein 3; protein dpy-19 homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178704.3 → NP_848819.2 probable C-mannosyltransferase DPY19L3

See identical proteins and their annotated locations for NP_848819.2

Status: VALIDATED

Source sequence(s)

AC166160, AK034217, AK045758

Consensus CDS

CCDS21155.1

UniProtKB/Swiss-Prot

Q6PB46, Q71B07, Q80W29, Q8BLA9, Q8BZL3, Q8BZW5

Related

ENSMUSP00000054747.9, ENSMUST00000051377.15

Conserved Domains (1) summary

pfam10034
Location:56 → 711

Dpy19; Q-cell neuroblast polarization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

35384925..35453879 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539906.2 → XP_006539969.1 probable C-mannosyltransferase DPY19L3 isoform X1

Conserved Domains (1) summary

pfam10034
Location:1 → 449

Dpy19; Q-cell neuroblast polarisation