Ffar2 free fatty acid receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ffar2provided by MGI
Official Full Name: free fatty acid receptor 2provided by MGI
Primary source: MGI:MGI:2441731
See related: Ensembl:ENSMUSG00000051314 AllianceGenome:MGI:2441731
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr43; GPCR43
Summary: Enables G protein-coupled receptor activity. Involved in several processes, including leukocyte chemotaxis involved in inflammatory response; positive regulation of acute inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Predicted to be located in cell projection and plasma membrane. Is expressed in pancreas; pancreas epithelium; superior cervical ganglion; and testis. Orthologous to human FFAR2 (free fatty acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 10.2), subcutaneous fat pad adult (RPKM 8.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.25 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30517778..30523200, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30818031..30823775, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells.
Title: The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells.
GPR41 and GPR43 regulate CD8[+] T cell priming during herpes simplex virus type 1 infection.
Title: GPR41 and GPR43 regulate CD8(+) T cell priming during herpes simplex virus type 1 infection.
FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion.
Title: FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion.
Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice.
Title: Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice.
GPR43 stimulation on TCRalphabeta[+] intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.
Title: GPR43 stimulation on TCRαβ(+) intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.
Consumption of barley flour increases gut fermentation and improves glucose intolerance via the short-chain fatty acid receptor GPR43 in obese male mice.
Title: Consumption of barley flour increases gut fermentation and improves glucose intolerance via the short-chain fatty acid receptor GPR43 in obese male mice.
Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner.
Title: Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner.
Changes in gut microbiota, metabolite SCFAs, and GPR43 expression in obese diabetic mice after sleeve gastrectomy.
Title: Changes in gut microbiota, metabolite SCFAs, and GPR43 expression in obese diabetic mice after sleeve gastrectomy.
GPR43 Suppresses Intestinal Tumor Growth by Modification of the Mammalian Target of Rapamycin Complex 1 Activity in ApcMin/+ Mice.
Title: GPR43 Suppresses Intestinal Tumor Growth by Modification of the Mammalian Target of Rapamycin Complex 1 Activity in ApcMin/+ Mice.
Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Title: Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

Ffar2 (e-PCR), detects polymorphism
- UniSTS:534575

ha1258 (e-PCR)
- UniSTS:515421

Ffar2 (e-PCR), detects polymorphism
- UniSTS:525221

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte chemotaxis involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peptide hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: free fatty acid receptor 2

Names: G protein-coupled receptor 43; leukocyte-specific STAT-induced GPCR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168509.1 → NP_001161981.1 free fatty acid receptor 2

See identical proteins and their annotated locations for NP_001161981.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AI607149, AK078861

Consensus CDS

CCDS21111.1

UniProtKB/Swiss-Prot

Q8VCK6

Related

ENSMUSP00000129398.2, ENSMUST00000168528.8

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001168510.1 → NP_001161982.1 free fatty acid receptor 2

See identical proteins and their annotated locations for NP_001161982.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AI573563, AK078861

Consensus CDS

CCDS21111.1

UniProtKB/Swiss-Prot

Q8VCK6

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001168511.1 → NP_001161983.1 free fatty acid receptor 2

See identical proteins and their annotated locations for NP_001161983.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AK078861, CX231878

Consensus CDS

CCDS21111.1

UniProtKB/Swiss-Prot

Q8VCK6

Related

ENSMUSP00000127758.2, ENSMUST00000163504.8

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001168512.1 → NP_001161984.1 free fatty acid receptor 2

See identical proteins and their annotated locations for NP_001161984.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AC165340, AK078861, CX228700

Consensus CDS

CCDS21111.1

UniProtKB/Swiss-Prot

Q8VCK6

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_146187.4 → NP_666299.1 free fatty acid receptor 2

See identical proteins and their annotated locations for NP_666299.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.

Source sequence(s)

AK078861

Consensus CDS

CCDS21111.1

UniProtKB/Swiss-Prot

Q8VCK6

Related

ENSMUSP00000052600.4, ENSMUST00000053156.10

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

30517778..30523200 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250554.4 → XP_011248856.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011248856.1

UniProtKB/Swiss-Prot

Q8VCK6

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011250549.4 → XP_011248851.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011248851.1

UniProtKB/Swiss-Prot

Q8VCK6

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011250548.4 → XP_011248850.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011248850.1

UniProtKB/Swiss-Prot

Q8VCK6

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011250553.3 → XP_011248855.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011248855.1

UniProtKB/Swiss-Prot

Q8VCK6

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011250552.3 → XP_011248854.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011248854.1

UniProtKB/Swiss-Prot

Q8VCK6

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors