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Rasgrp4 RAS guanyl releasing protein 4 [ Mus musculus (house mouse) ]

Gene ID: 233046, updated on 21-Apr-2024

Summary

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Official Symbol
Rasgrp4provided by MGI
Official Full Name
RAS guanyl releasing protein 4provided by MGI
Primary source
MGI:MGI:2386851
See related
Ensembl:ENSMUSG00000030589 AllianceGenome:MGI:2386851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cell population proliferation; positive regulation of Ras protein signal transduction; and response to extracellular stimulus. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in several structures, including genitourinary system; liver; peritoneal cavity; spleen; and tongue. Orthologous to human RASGRP4 (RAS guanyl releasing protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 8.9), duodenum adult (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 16.94 cM; 7 B1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28834358..28853386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29134607..29153961)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene predicted gene, 26604 Neighboring gene STARR-seq mESC enhancer starr_18458 Neighboring gene microRNA 1963 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29926525-29926755 Neighboring gene STARR-positive B cell enhancer ABC_E9287 Neighboring gene family with sequence similarity 98, member C Neighboring gene STARR-positive B cell enhancer ABC_E8159 Neighboring gene sprouty-related EVH1 domain containing 3 Neighboring gene gametogenetin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide. Zhou S, et al. PLoS One, 2016. PMID 26982501, Free PMC Article
  2. Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. Adachi R, et al. J Biol Chem, 2012 Jun 8. PMID 22511759, Free PMC Article
  3. RasGRP4 in mast cell signalling and disease susceptibility. Stevens RL, et al. Novartis Found Symp, 2005. PMID 16605128
  4. The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development. Zhu M, et al. J Biol Chem, 2012 Mar 9. PMID 22262848, Free PMC Article
  5. Possible involvement of RasGRP4 in leukemogenesis. Watanabe-Okochi N, et al. Int J Hematol, 2009 May. PMID 19350351

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RasGRP4 is required for CD117+ MCs and DCs to optimally induce acute NK cell-dependent immune responses to LPS helps explain why this signaling protein has been conserved in evolution
    Title: CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.
  2. Rasgrp4 is an activity dependent gene in mouse olfactory sensory neurons. [Rasgrp4]
    Title: Activity-dependent genes in mouse olfactory sensory neurons.
  3. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
    Title: GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
  4. Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis.
    Title: Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis.
  5. Despite high levels of RasGRP4 expression in mast cells, RasGRP4 deficiency led to only a modest reduction in FcepsilonRI-mediated degranulation and cytokine production.
    Title: The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.
  6. RasGRP4 cooperates with AML1 mutations in T cell leukemogenesis as a class I mutation
    Title: Possible involvement of RasGRP4 in leukemogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAS guanyl-releasing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174155.1 → NP_001167626.1  RAS guanyl-releasing protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC164564, AK049562, BY749980
    Consensus CDS
    CCDS85258.1
    UniProtKB/TrEMBL
    E9QKB7
    Related
    ENSMUSP00000125137.2, ENSMUST00000159975.8
    Conserved Domains (4) summary
    smart00147
    Location:197 → 432
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:541 → 595
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:465 → 494
    EF-hand_7; EF-hand domain pair
    cl02520
    Location:82 → 164
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  2. NM_145149.4 → NP_660131.2  RAS guanyl-releasing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_660131.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC164564, AK049562, BY749980
    Consensus CDS
    CCDS85257.1
    UniProtKB/Swiss-Prot
    Q3TNQ1, Q3TRL5, Q3U3I4, Q811P7, Q8BKV7, Q8BTM9, Q91ZC8, Q920A2
    UniProtKB/TrEMBL
    E9QKB7
    Related
    ENSMUSP00000032811.6, ENSMUST00000032811.12
    Conserved Domains (4) summary
    smart00147
    Location:197 → 432
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:541 → 590
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:465 → 494
    EF-hand_7; EF-hand domain pair
    cl02520
    Location:82 → 164
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

RNA

  1. NR_045676.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC164564

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28834358..28853386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250525.2 → XP_011248827.1  RAS guanyl-releasing protein 4 isoform X2

    UniProtKB/TrEMBL
    E9QKB7
    Related
    ENSMUSP00000124183.2, ENSMUST00000159351.3
    Conserved Domains (3) summary
    smart00147
    Location:197 → 432
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:541 → 595
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:82 → 164
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  2. XM_017322159.3 → XP_017177648.1  RAS guanyl-releasing protein 4 isoform X1

    UniProtKB/TrEMBL
    E9QKB7
    Conserved Domains (3) summary
    smart00147
    Location:201 → 436
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:545 → 599
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:86 → 168
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  3. XM_017322161.3 → XP_017177650.1  RAS guanyl-releasing protein 4 isoform X4

    UniProtKB/TrEMBL
    E9QKB7
    Conserved Domains (3) summary
    smart00147
    Location:201 → 436
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:545 → 599
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:86 → 168
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  4. XM_017322160.3 → XP_017177649.1  RAS guanyl-releasing protein 4 isoform X3

    UniProtKB/TrEMBL
    E9QKB7
    Conserved Domains (3) summary
    smart00147
    Location:201 → 436
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:545 → 594
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:86 → 168
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  5. XM_017322162.3 → XP_017177651.1  RAS guanyl-releasing protein 4 isoform X5

    UniProtKB/TrEMBL
    E9QKB7
    Conserved Domains (3) summary
    smart00147
    Location:201 → 436
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:545 → 594
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:86 → 168
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  6. XM_017322163.3 → XP_017177652.1  RAS guanyl-releasing protein 4 isoform X6

    UniProtKB/TrEMBL
    E9QKB7
    Conserved Domains (3) summary
    smart00147
    Location:155 → 390
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:499 → 553
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:40 → 122
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  7. XM_017322164.3 → XP_017177653.1  RAS guanyl-releasing protein 4 isoform X7

    UniProtKB/TrEMBL
    E9QKB7
    Conserved Domains (3) summary
    smart00147
    Location:201 → 436
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl00040
    Location:545 → 582
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:86 → 168
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

  8. XM_017322165.3 → XP_017177654.1  RAS guanyl-releasing protein 4 isoform X8

    UniProtKB/TrEMBL
    E9QKB7
    Conserved Domains (3) summary
    smart00147
    Location:201 → 436
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:545 → 577
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl02520
    Location:86 → 168
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

RNA

  1. XR_001785525.3 RNA Sequence

  2. XR_001785526.3 RNA Sequence

  3. XR_001785524.3 RNA Sequence

  4. XR_001785523.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTM9.1 GenPept UniProtKB/Swiss-Prot:Q8BTM9

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