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Blvrb biliverdin reductase B [ Mus musculus (house mouse) ]

Gene ID: 233016, updated on 21-Apr-2024

Summary

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Official Symbol
Blvrbprovided by MGI
Official Full Name
biliverdin reductase Bprovided by MGI
Primary source
MGI:MGI:2385271
See related
Ensembl:ENSMUSG00000040466 AllianceGenome:MGI:2385271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable biliverdin reductase (NAD(P)+) activity and riboflavin reductase (NADPH) activity. Predicted to be involved in heme catabolic process. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and terminal bouton. Is expressed in liver; nervous system; respiratory system; and sensory organ. Orthologous to human BLVRB (biliverdin reductase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 398.9), liver E14 (RPKM 344.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 15.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27147403..27165406)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27447978..27465981)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Sh3kbp1 binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1726 Neighboring gene STARR-positive B cell enhancer ABC_E1727 Neighboring gene STARR-positive B cell enhancer ABC_E2820 Neighboring gene spectrin beta, non-erythrocytic 4 Neighboring gene STARR-seq mESC enhancer starr_18360 Neighboring gene STARR-positive B cell enhancer ABC_E4908 Neighboring gene STARR-positive B cell enhancer ABC_E2230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28258388-28258575 Neighboring gene phosphoglycerate mutase 1, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E1336 Neighboring gene SERTA domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis. Nesbitt NM, et al. Free Radic Biol Med, 2021 Feb 20. PMID 33359909, Free PMC Article
  2. Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis. Chemaly M, et al. Biomolecules, 2023 May 24. PMID 37371462, Free PMC Article
  3. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
  4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.
    Title: Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.
  2. Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis.
    Title: Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC11726, MGC27866

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables biliberdin reductase NAD+ activity IEA
Inferred from Electronic Annotation
more info
  
enables biliverdin reductase (NAD(P)H) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables biliverdin reductase (NAD(P)H) activity ISO
Inferred from Sequence Orthology
more info
  
enables biliverdin reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-cysteine S-nitrosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-cysteine S-nitrosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables riboflavin reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heme catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
flavin reductase (NADPH)
Names
BVR-B
FLR
FR
NADPH-dependent diaphorase
NADPH-flavin reductase
biliverdin-IX beta-reductase
NP_001277454.1
NP_659172.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290525.1 → NP_001277454.1  flavin reductase (NADPH) isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC158304
    Consensus CDS
    CCDS71922.1
    UniProtKB/TrEMBL
    E9PZC4
    Related
    ENSMUSP00000103994.2, ENSMUST00000108357.8
    Conserved Domains (2) summary
    COG0451
    Location:3 → 68
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    cl21454
    Location:1 → 114
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_144923.3 → NP_659172.1  flavin reductase (NADPH) isoform 1

    See identical proteins and their annotated locations for NP_659172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158304
    Consensus CDS
    CCDS39848.1
    UniProtKB/Swiss-Prot
    Q923D2
    UniProtKB/TrEMBL
    Q3U6G1
    Related
    ENSMUSP00000043092.10, ENSMUST00000037399.16
    Conserved Domains (2) summary
    cd05244
    Location:5 → 200
    BVR-B_like_SDR_a; biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs
    COG0451
    Location:4 → 154
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27147403..27165406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923D2.3 GenPept UniProtKB/Swiss-Prot:Q923D2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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