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Lypd4 Ly6/Plaur domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 232973, updated on 5-Mar-2024

Summary

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Official Symbol
Lypd4provided by MGI
Official Full Name
Ly6/Plaur domain containing 4provided by MGI
Primary source
MGI:MGI:2687054
See related
Ensembl:ENSMUSG00000062732 AllianceGenome:MGI:2687054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933400F01Rik
Summary
Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in plasma membrane raft. Predicted to be anchored component of plasma membrane. Orthologous to human LYPD4 (LY6/PLAUR domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 398.2) See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 13.3 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24564044..24569180, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24864617..24869924, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cysteine rich protein 2 pseudogene Neighboring gene thymosin beta 10b Neighboring gene doublesex and mab-3 related transcription factor like family C2 Neighboring gene predicted gene, 38966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669208-25669317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669584-25669693 Neighboring gene ribosomal protein S19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility†. Wang D, et al. Biol Reprod, 2020 Apr 24. PMID 32040177
  2. Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Fujihara Y, et al. Proc Natl Acad Sci U S A, 2019 Sep 10. PMID 31455729, Free PMC Article
  3. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertilitydagger.
    Title: LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility†.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC58778

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ly6/PLAUR domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419266.1 → NP_001406195.1  ly6/PLAUR domain-containing protein 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/Swiss-Prot
    Q8BVP6

  2. NM_182785.4 → NP_877586.1  ly6/PLAUR domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_877586.1

    Status: VALIDATED

    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS20964.1
    UniProtKB/Swiss-Prot
    Q8BVP6
    Related
    ENSMUSP00000078287.5, ENSMUST00000079306.11
    Conserved Domains (1) summary
    pfam00021
    Location:142 → 212
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24564044..24569180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVP6.1 GenPept UniProtKB/Swiss-Prot:Q8BVP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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