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Mypop Myb-related transcription factor, partner of profilin [ Mus musculus (house mouse) ]

Gene ID: 232934, updated on 5-Mar-2024

Summary

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Official Symbol
Mypopprovided by MGI
Official Full Name
Myb-related transcription factor, partner of profilinprovided by MGI
Primary source
MGI:MGI:2446472
See related
Ensembl:ENSMUSG00000048481 AllianceGenome:MGI:2446472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P42pop; Myodysa
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human MYPOP (Myb related transcription factor, partner of profilin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 11.9), testis adult (RPKM 10.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18725230..18735691)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18991240..19001766)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NOVA alternative splicing regulator 2 Neighboring gene predicted gene, 38952 Neighboring gene STARR-positive B cell enhancer ABC_E1080 Neighboring gene nanos C2HC-type zinc finger 2 Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene forkhead box A3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Physical and genetic characterization of the distal segment of the myotonic dystrophy area on 19q. Jansen G, et al. Genomics, 1992 Jul. PMID 1639379
  2. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Krappa R, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200314, Free PMC Article
  3. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. Lederer M, et al. J Cell Sci, 2005 Jan 15. PMID 15615774
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myb-related transcription factor, partner of profilin
Names
Myb protein P42POP
myb-related protein p42POP
myotonic dystrophy region
partner of profilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420727.1 → NP_001407656.1  myb-related transcription factor, partner of profilin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC170864
    UniProtKB/Swiss-Prot
    Q7TNR1, Q8CFP0, Q8R4U1

  2. NM_001420728.1 → NP_001407657.1  myb-related transcription factor, partner of profilin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC170864

  3. NM_001420729.1 → NP_001407658.1  myb-related transcription factor, partner of profilin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC170864

  4. NM_145579.4 → NP_663554.1  myb-related transcription factor, partner of profilin isoform 1

    See identical proteins and their annotated locations for NP_663554.1

    Status: VALIDATED

    Source sequence(s)
    AC170864
    Consensus CDS
    CCDS39792.1
    UniProtKB/Swiss-Prot
    Q7TNR1, Q8CFP0, Q8R4U1
    Related
    ENSMUSP00000058718.9, ENSMUST00000059331.9
    Conserved Domains (1) summary
    pfam13873
    Location:20 → 96
    Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18725230..18735691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4U1.1 GenPept UniProtKB/Swiss-Prot:Q8R4U1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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