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Ccdc61 coiled-coil domain containing 61 [ Mus musculus (house mouse) ]

Gene ID: 232933, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc61provided by MGI
Official Full Name
coiled-coil domain containing 61provided by MGI
Primary source
MGI:MGI:2685005
See related
Ensembl:ENSMUSG00000074358 AllianceGenome:MGI:2685005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm159; C530028I08Rik
Summary
Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in centriole assembly and mitotic spindle assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in centriolar satellite and ciliary basal body. Predicted to be part of centriolar subdistal appendage. Predicted to be active in centrosome. Orthologous to human CCDC61 (coiled-coil domain containing 61). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.9), thymus adult (RPKM 11.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.38 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18624808..18644417, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18890883..18910414, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MHC I like leukocyte 2 Neighboring gene peptidoglycan recognition protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E66 Neighboring gene STARR-seq mESC enhancer starr_18181 Neighboring gene NOVA alternative splicing regulator 2 Neighboring gene STARR-seq mESC enhancer starr_18182 Neighboring gene predicted gene, 38952 Neighboring gene nanos C2HC-type zinc finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein CCDC61
Names
VFL3 homolog
coiled-coil domain-containing protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033314.4 → NP_001028486.1  centrosomal protein CCDC61 isoform 1

    See identical proteins and their annotated locations for NP_001028486.1

    Status: VALIDATED

    Source sequence(s)
    AC153651
    Consensus CDS
    CCDS39791.1
    UniProtKB/Swiss-Prot
    Q3UJV1
    Related
    ENSMUSP00000096377.4, ENSMUST00000098780.10
    Conserved Domains (1) summary
    COG1196
    Location:148 → 274
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001419239.1 → NP_001406168.1  centrosomal protein CCDC61 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153651

  3. NM_001419240.1 → NP_001406169.1  centrosomal protein CCDC61 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153651
    UniProtKB/Swiss-Prot
    Q3UJV1

  4. NM_001419241.1 → NP_001406170.1  centrosomal protein CCDC61 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153651
    UniProtKB/Swiss-Prot
    Q3UJV1

  5. NM_001419242.1 → NP_001406171.1  centrosomal protein CCDC61 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153651
    UniProtKB/Swiss-Prot
    Q3UJV1

  6. NM_001419244.1 → NP_001406173.1  centrosomal protein CCDC61 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153651

  7. NM_001419245.1 → NP_001406174.1  centrosomal protein CCDC61 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153651

  8. NM_001419246.1 → NP_001406175.1  centrosomal protein CCDC61 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153651

  9. NM_001419247.1 → NP_001406176.1  centrosomal protein CCDC61 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153651

RNA

  1. NR_185052.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153651
    Related
    ENSMUST00000135467.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18624808..18644417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152947.1 → XP_036008840.1  centrosomal protein CCDC61 isoform X3

  2. XM_006539814.5 → XP_006539877.2  centrosomal protein CCDC61 isoform X2

    See identical proteins and their annotated locations for XP_006539877.2

    UniProtKB/Swiss-Prot
    Q3UJV1
    Conserved Domains (1) summary
    COG1196
    Location:148 → 274
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_391057.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UJV1.1 GenPept UniProtKB/Swiss-Prot:Q3UJV1

Gene LinkOut

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