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Pla2g4c phospholipase A2, group IVC (cytosolic, calcium-independent) [ Mus musculus (house mouse) ]

Gene ID: 232889, updated on 5-Mar-2024

Summary

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Official Symbol
Pla2g4cprovided by MGI
Official Full Name
phospholipase A2, group IVC (cytosolic, calcium-independent)provided by MGI
Primary source
MGI:MGI:1196403
See related
Ensembl:ENSMUSG00000033847 AllianceGenome:MGI:1196403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Ertd445e
Summary
Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipid binding activity; and phospholipase activity. Predicted to be involved in glycerophospholipid metabolic process and lipid droplet formation. Predicted to act upstream of or within lipid metabolic process. Located in cell cortex; nuclear envelope; and nucleoplasm. Is expressed in central nervous system; early conceptus; ovary; and retina. Orthologous to human PLA2G4C (phospholipase A2 group IVC). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 7.84 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13045432..13094597)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13311507..13360674)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 69 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene STARR-positive B cell enhancer ABC_E4896 Neighboring gene ligase I, DNA, ATP-dependent Neighboring gene STARR-seq mESC enhancer starr_18078 Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene Neighboring gene calcium binding protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Induction of group IVC phospholipase A2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells. Bickford JS, et al. Biochem J, 2012 Feb 15. PMID 22082005
  2. Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation. Mancuso DJ, et al. J Biol Chem, 2010 Nov 19. PMID 20817734, Free PMC Article
  3. Mouse cPLA2gamma, a novel oocyte and early embryo-abundant phospholipase A2 gamma-like protein, is targeted to the nuclear envelope during germinal vesicle breakdown. Vitale A, et al. Dev Biol, 2005 Jun 15. PMID 15950603
  4. Augmented Pla2g4c/Ptgs2/Hpgds axis in bronchial smooth muscle tissues of experimental asthma. Chiba Y, et al. PLoS One, 2018. PMID 30161143, Free PMC Article
  5. cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. Vignola MJ, et al. J Biol Chem, 2010 Jul 9. PMID 20452986, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Validation of differentially expressed genes (DEGs) by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. A 24-h incubation of BSM tissues with PGD2 caused a hyperresponsiveness to acetylcholine in naive control mice.
    Title: Augmented Pla2g4c/Ptgs2/Hpgds axis in bronchial smooth muscle tissues of experimental asthma.
  2. results link cytokine-mediated alterations in cPLA2gamma gene expression with allergic asthma and outline a complex regulatory mechanism
    Title: Induction of group IVC phospholipase A2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells.
  3. Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
    Title: Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
  4. cPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia
    Title: cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis.
  5. iPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts
    Title: Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet activating factor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytosolic phospholipase A2 gamma
Names
CPLA2-gamma
cytosolic lysophospholipase
cytosolic lysophospholipid O-acyltransferase
egg and early embryo abundant protein
NP_001004762.1
NP_001161976.1
XP_006539868.1
XP_036008837.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004762.3 → NP_001004762.1  cytosolic phospholipase A2 gamma isoform 2

    See identical proteins and their annotated locations for NP_001004762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC161792, AK136098
    Consensus CDS
    CCDS39771.1
    UniProtKB/Swiss-Prot
    Q08EC7, Q3UWS1, Q64GA5, Q7TN01
    Related
    ENSMUSP00000043672.10, ENSMUST00000043612.10
    Conserved Domains (1) summary
    cd07202
    Location:5 → 561
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent

  2. NM_001168504.1 → NP_001161976.1  cytosolic phospholipase A2 gamma isoform 1

    See identical proteins and their annotated locations for NP_001161976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161792, BC117808
    Consensus CDS
    CCDS52027.1
    UniProtKB/Swiss-Prot
    Q64GA5
    Related
    ENSMUSP00000104168.3, ENSMUST00000108528.9
    Conserved Domains (1) summary
    cd07202
    Location:15 → 571
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    13045432..13094597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152944.1 → XP_036008837.1  cytosolic phospholipase A2 gamma isoform X1

    Conserved Domains (1) summary
    cd07202
    Location:97 → 653
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent

  2. XM_006539805.3 → XP_006539868.1  cytosolic phospholipase A2 gamma isoform X1

    Conserved Domains (1) summary
    cd07202
    Location:97 → 653
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64GA5.1 GenPept UniProtKB/Swiss-Prot:Q64GA5

Gene LinkOut

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