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Zscan22 zinc finger and SCAN domain containing 22 [ Mus musculus (house mouse) ]

Gene ID: 232878, updated on 5-Mar-2024

Summary

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Official Symbol
Zscan22provided by MGI
Official Full Name
zinc finger and SCAN domain containing 22provided by MGI
Primary source
MGI:MGI:2443312
See related
Ensembl:ENSMUSG00000054715 AllianceGenome:MGI:2443312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hkr2; D530006B18Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human ZSCAN22 (zinc finger and SCAN domain containing 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 7.4), ovary adult (RPKM 6.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 7.68 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12631736..12643010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12897798..12909083)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45971 Neighboring gene STARR-positive B cell enhancer ABC_E6510 Neighboring gene zinc finger protein 128 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13482923-13483223 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13495643-13495826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13507414-13507597 Neighboring gene ribosomal protein S5 Neighboring gene ring finger protein 225 Neighboring gene predicted gene, 26325

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 22
Names
GLI-Kruppel family member HKR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001447.3 → NP_001001447.1  zinc finger and SCAN domain-containing protein 22 isoform a

    See identical proteins and their annotated locations for NP_001001447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK052559, AK163694, BB849089
    Consensus CDS
    CCDS20816.1
    UniProtKB/TrEMBL
    Q8BGS5
    Related
    ENSMUSP00000057651.5, ENSMUST00000055528.11
    Conserved Domains (3) summary
    COG5048
    Location:181 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:45 → 129
    SCAN; SCAN domain

  2. NM_001290436.1 → NP_001277365.1  zinc finger and SCAN domain-containing protein 22 isoform a

    See identical proteins and their annotated locations for NP_001277365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC107704, AK052559, AK163694, BB849089, BB871911
    Consensus CDS
    CCDS20816.1
    UniProtKB/TrEMBL
    Q8BGS5
    Conserved Domains (3) summary
    COG5048
    Location:181 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:45 → 129
    SCAN; SCAN domain

  3. NM_001290438.1 → NP_001277367.1  zinc finger and SCAN domain-containing protein 22 isoform a

    See identical proteins and their annotated locations for NP_001277367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant (1). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK078591, AK163694, BB849089
    Consensus CDS
    CCDS20816.1
    UniProtKB/TrEMBL
    Q8BGS5
    Related
    ENSMUSP00000113314.2, ENSMUST00000120809.2
    Conserved Domains (3) summary
    COG5048
    Location:181 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:45 → 129
    SCAN; SCAN domain

  4. NM_001290440.1 → NP_001277369.1  zinc finger and SCAN domain-containing protein 22 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and lacks an alternate exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK163694, BB849089
    UniProtKB/TrEMBL
    Q3TQC3
    Conserved Domains (3) summary
    COG5048
    Location:66 → 364
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:213 → 233
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:225 → 250
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001290441.1 → NP_001277370.1  zinc finger and SCAN domain-containing protein 22 isoform c

    See identical proteins and their annotated locations for NP_001277370.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 3' end of the first exon and lacks an alternate exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (c).
    Source sequence(s)
    AK163694, BB849089, BY288068
    Consensus CDS
    CCDS71889.1
    UniProtKB/TrEMBL
    Q3TQC3
    Related
    ENSMUSP00000113486.2, ENSMUST00000119989.3
    Conserved Domains (2) summary
    COG5048
    Location:22 → 320
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001290442.1 → NP_001277371.1  zinc finger and SCAN domain-containing protein 22 isoform c

    See identical proteins and their annotated locations for NP_001277371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (c).
    Source sequence(s)
    AC107704, AK163694, BB849089
    Consensus CDS
    CCDS71889.1
    UniProtKB/TrEMBL
    Q3TQC3
    Related
    ENSMUSP00000112684.2, ENSMUST00000117189.2
    Conserved Domains (2) summary
    COG5048
    Location:22 → 320
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12631736..12643010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242427.2 → XP_030098287.1  zinc finger and SCAN domain-containing protein 22 isoform X1

    UniProtKB/TrEMBL
    Q3TQC3
    Conserved Domains (2) summary
    COG5048
    Location:22 → 320
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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