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Shisa7 shisa family member 7 [ Mus musculus (house mouse) ]

Gene ID: 232813, updated on 11-Apr-2024

Summary

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Official Symbol
Shisa7provided by MGI
Official Full Name
shisa family member 7provided by MGI
Primary source
MGI:MGI:3605641
See related
Ensembl:ENSMUSG00000053550 AllianceGenome:MGI:3605641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ckamp59
Summary
Enables GABA receptor binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Is integral component of postsynaptic specialization membrane. Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; rib; and tail mesenchyme. Orthologous to human SHISA7 (shisa family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 32.2), whole brain E14.5 (RPKM 29.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Shisa7 in Genome Data Viewer
Location:
7 A1; 7 2.79 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4828551..4847788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4825551..4844866, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57780 Neighboring gene ribosomal protein L28 Neighboring gene STARR-positive B cell enhancer ABC_E441 Neighboring gene ubiquitin-conjugating enzyme E2S Neighboring gene STARR-seq mESC enhancer starr_17941 Neighboring gene predicted gene, 36127 Neighboring gene isochorismatase domain containing 2b Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4817662-4817771 Neighboring gene predicted gene, 53350 Neighboring gene STARR-positive B cell enhancer ABC_E2220 Neighboring gene isochorismatase domain containing 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activity- and sleep-dependent regulation of tonic inhibition by Shisa7. Wu K, et al. Cell Rep, 2021 Mar 23. PMID 33761345, Free PMC Article
  2. Shisa7 is a GABA(A) receptor auxiliary subunit controlling benzodiazepine actions. Han W, et al. Science, 2019 Oct 11. PMID 31601770, Free PMC Article
  3. The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory. Schmitz LJM, et al. Elife, 2017 Dec 4. PMID 29199957, Free PMC Article
  4. Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties. Farrow P, et al. Elife, 2015 Dec 1. PMID 26623514, Free PMC Article
  5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.
    Title: Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.
  2. data indicate that Shisa7 regulates GABAAR trafficking, function, and pharmacology and reveal a previously unknown molecular interaction that modulates benzodiazepine action in the brain
    Title: Shisa7 is a GABA(A) receptor auxiliary subunit controlling benzodiazepine actions.
  3. Thus, Shisa7 is a bona-fide AMPA receptor modulatory protein affecting channel kinetics of the receptors, necessary for synaptic hippocampal plasticity, and memory recall.
    Title: The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory.
  4. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members 39, 52 and 59.
    Title: Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • D430041B17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables ionotropic glutamate receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ionotropic glutamate receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid receptor clustering IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of AMPA glutamate receptor clustering IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of AMPA receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of GABA-A receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
NOT part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in asymmetric, glutamatergic, excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in asymmetric, glutamatergic, excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendritic spine membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein shisa-7
Names
GABA(A) receptor auxiliary subunit Shisa7
cysteine-knot AMPAR-modulating protein 59
cystine-knot AMPAR modulating protein of 59 kDa
shisa homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290291.1 → NP_001277220.1  protein shisa-7 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC162034, AK085127, CJ120465
    Consensus CDS
    CCDS71882.1
    UniProtKB/Swiss-Prot
    Q8C3Q5
    UniProtKB/TrEMBL
    A0A172Q401
    Related
    ENSMUSP00000112423.3, ENSMUST00000119433.4
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

  2. NM_172737.4 → NP_766325.3  protein shisa-7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766325.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC162034, AK085127, CF538627, CJ120465
    UniProtKB/Swiss-Prot
    A0A172Q401, A0A172Q418, Q3UMB3, Q8C3Q5
    Related
    ENSMUSP00000064886.6, ENSMUST00000066041.12
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 136
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4828551..4847788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242416.2 → XP_030098276.1  protein shisa-7 isoform X2

    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator

  2. XM_006539775.5 → XP_006539838.1  protein shisa-7 isoform X1

    See identical proteins and their annotated locations for XP_006539838.1

    UniProtKB/Swiss-Prot
    A0A172Q401, A0A172Q418, Q3UMB3, Q8C3Q5
    Conserved Domains (1) summary
    pfam13908
    Location:83 → 136
    Shisa; Wnt and FGF inhibitory regulator

  3. XM_030242417.2 → XP_030098277.1  protein shisa-7 isoform X3

    Conserved Domains (1) summary
    pfam13908
    Location:83 → 142
    Shisa; Wnt and FGF inhibitory regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C3Q5.3 GenPept UniProtKB/Swiss-Prot:Q8C3Q5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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