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Cnot3 CCR4-NOT transcription complex, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 232791, updated on 18-Apr-2024

Summary

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Official Symbol
Cnot3provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 3provided by MGI
Primary source
MGI:MGI:2385261
See related
Ensembl:ENSMUSG00000035632 AllianceGenome:MGI:2385261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930039N10Rik
Summary
Involved in positive regulation of cold-induced thermogenesis; regulation of stem cell population maintenance; and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and white fat. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.9), limb E14.5 (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 2.1 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3646717..3664108)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3645247..3661109)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TCF3 (E2A) fusion partner Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:3581200-3581309 Neighboring gene STARR-positive B cell enhancer ABC_E2811 Neighboring gene pre-mRNA processing factor 31 Neighboring gene predicted gene 15927 Neighboring gene STARR-seq mESC enhancer starr_17914 Neighboring gene microRNA 3572 Neighboring gene STARR-positive B cell enhancer ABC_E1077 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene membrane bound O-acyltransferase domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stability of mRNA influences osteoporotic bone mass via CNOT3. Watanabe C, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550297, Free PMC Article
  2. Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis. Yang CY, et al. Genes Dev, 2016 Oct 15. PMID 27807034, Free PMC Article
  3. CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. Inoue T, et al. J Exp Med, 2015 Aug 24. PMID 26238124, Free PMC Article
  4. CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells. Sarkar M, et al. Mol Biol Cell, 2021 Dec 1. PMID 34613789, Free PMC Article
  5. Insufficient liver maturation affects murine early postnatal hair cycle. Suzuki T, et al. Biochem Biophys Res Commun, 2020 Jan 1. PMID 31630801

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
    Title: CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
  2. Loss of beta-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation.
    Title: Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation.
  3. Cnot3 plays a crucial role in liver functional maturation
    Title: Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.
  4. Data indicate that autophagy-related protein 7 (Atg7) promotes cardiac dysfunction of CCR4-NOT complex component Cnot3 knockout (Cnot3 mKO) mice independently of the canonical autophagy pathway.
    Title: The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function.
  5. we propose that CNOT3 maintains the pluripotent state by promoting differentiation gene mRNA deadenylation and degradation, and we identify poly(A) tail-length regulation as a post-transcriptional mechanism that controls pluripotency.
    Title: CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State.
  6. Cnot3(ad-/-) mice exhibit lipodystrophy.
    Title: Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy.
  7. increases the number of ALP-positive colonies after iPSC induction and decreases expression levels of Eomes and p21 mRNAs. Based on these observations, we propose that the CCR4-NOT deadenylase activity contributes to iPSC induction.
    Title: The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells.
  8. CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins, Ripk1 and Ripk3.
    Title: CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins.
  9. data suggest that the CCR4-NOT complex regulates B cell differentiation by controlling Igh rearrangement and destabilizing p53 mRNA.
    Title: CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.
  10. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
    Title: Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40675

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of stem cell population maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 3
Names
CCR4-associated factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146176.3 → NP_666288.1  CCR4-NOT transcription complex subunit 3

    See identical proteins and their annotated locations for NP_666288.1

    Status: VALIDATED

    Source sequence(s)
    BC053437, BQ748712, CV783268
    Consensus CDS
    CCDS20721.1
    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    Q6A015
    Related
    ENSMUSP00000039098.10, ENSMUST00000038913.16
    Conserved Domains (2) summary
    COG5665
    Location:12 → 749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3646717..3664108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152919.1 → XP_036008812.1  CCR4-NOT transcription complex subunit 3 isoform X1

    Conserved Domains (2) summary
    COG5665
    Location:210 → 929
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:211 → 409
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  2. XM_036152920.1 → XP_036008813.1  CCR4-NOT transcription complex subunit 3 isoform X2

    Conserved Domains (2) summary
    COG5665
    Location:210 → 928
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:211 → 408
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  3. XM_036152921.1 → XP_036008814.1  CCR4-NOT transcription complex subunit 3 isoform X3

    Conserved Domains (2) summary
    COG5665
    Location:209 → 928
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:210 → 408
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  4. XM_036152922.1 → XP_036008815.1  CCR4-NOT transcription complex subunit 3 isoform X4

    Conserved Domains (3) summary
    pfam05109
    Location:477 → 744
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam04065
    Location:211 → 409
    Not3; Not1 N-terminal domain, CCR4-Not complex component
    cl02384
    Location:798 → 860
    NOT2_3_5; NOT2 / NOT3 / NOT5 family

  5. XM_006539756.5 → XP_006539819.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539819.1

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  6. XM_030242409.2 → XP_030098269.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  7. XM_036152924.1 → XP_036008817.1  CCR4-NOT transcription complex subunit 3 isoform X6

    Conserved Domains (2) summary
    COG5665
    Location:130 → 849
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:131 → 329
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  8. XM_006539752.5 → XP_006539815.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539815.1

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  9. XM_036152927.1 → XP_036008820.1  CCR4-NOT transcription complex subunit 3 isoform X7

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  10. XM_036152930.1 → XP_036008823.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  11. XM_006539753.5 → XP_006539816.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539816.1

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  12. XM_030242407.2 → XP_030098267.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  13. XM_017322146.3 → XP_017177635.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  14. XM_036152928.1 → XP_036008821.1  CCR4-NOT transcription complex subunit 3 isoform X7

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  15. XM_006539755.5 → XP_006539818.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539818.1

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  16. XM_036152923.1 → XP_036008816.1  CCR4-NOT transcription complex subunit 3 isoform X5

    Conserved Domains (2) summary
    COG5665
    Location:131 → 850
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:132 → 330
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  17. XM_030242406.2 → XP_030098266.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  18. XM_036152926.1 → XP_036008819.1  CCR4-NOT transcription complex subunit 3 isoform X7

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  19. XM_030242408.2 → XP_030098268.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  20. XM_036152931.1 → XP_036008824.1  CCR4-NOT transcription complex subunit 3 isoform X9

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (1) summary
    COG5665
    Location:1 → 663
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

  21. XM_036152929.1 → XP_036008822.1  CCR4-NOT transcription complex subunit 3 isoform X7

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

  22. XM_036152925.1 → XP_036008818.1  CCR4-NOT transcription complex subunit 3 isoform X7

    UniProtKB/TrEMBL
    Q6A015
    Conserved Domains (2) summary
    COG5665
    Location:12 → 750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3 → 230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

RNA

  1. XR_004934061.1 RNA Sequence

  2. XR_003946437.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0V4.1 GenPept UniProtKB/Swiss-Prot:Q8K0V4

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