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Tcaf2 TRPM8 channel-associated factor 2 [ Mus musculus (house mouse) ]

Gene ID: 232748, updated on 5-Mar-2024

Summary

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Official Symbol
Tcaf2provided by MGI
Official Full Name
TRPM8 channel-associated factor 2provided by MGI
Primary source
MGI:MGI:2385258
See related
Ensembl:ENSMUSG00000029851 AllianceGenome:MGI:2385258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam115c
Summary
Predicted to enable transmembrane transporter binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cell junction. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human TCAF2 (TRPM8 channel associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.9), thymus adult (RPKM 1.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.1; 6 20.82 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42599950..42622134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42623043..42645041, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38798 Neighboring gene TRPM8 channel-associated factor 3 Neighboring gene TRPM8 channel-associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_15722 Neighboring gene olfactory receptor family 2 subfamily AR member 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. Gkika D, et al. J Cell Biol, 2015 Jan 5. PMID 25559186, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  3. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report novel TRP channel-associated factors that modulate TRPM8 activity.
    Title: TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC7793

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
TRPM8 channel-associated factor 2
Names
TRP channel-associated factor 2
family with sequence similarity 115, member C
protein FAM115C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146174.1 → NP_666286.1  TRPM8 channel-associated factor 2

    See identical proteins and their annotated locations for NP_666286.1

    Status: PROVISIONAL

    Source sequence(s)
    BC011487
    Consensus CDS
    CCDS20075.1
    UniProtKB/Swiss-Prot
    Q6KAN8, Q921K8, Q922C4
    Related
    ENSMUSP00000031879.4, ENSMUST00000031879.5
    Conserved Domains (1) summary
    pfam13402
    Location:521 → 890
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    42599950..42622134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166099.1 → XP_036021992.1  TRPM8 channel-associated factor 2 isoform X1

    Conserved Domains (2) summary
    pfam13402
    Location:391 → 647
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:295 → 390
    M60-like_N; N-terminal domain of M60-like peptidases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921K8.1 GenPept UniProtKB/Swiss-Prot:Q921K8

Gene LinkOut

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