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Caprin2 caprin family member 2 [ Mus musculus (house mouse) ]

Gene ID: 232560, updated on 5-Mar-2024

Summary

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Official Symbol
Caprin2provided by MGI
Official Full Name
caprin family member 2provided by MGI
Primary source
MGI:MGI:2448541
See related
Ensembl:ENSMUSG00000030309 AllianceGenome:MGI:2448541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adir; Eeg1; C1qdc1; rng140
Summary
This gene encodes a member of the caprin family. The encoded protein may function as an RNA-binding protein that induces the formation of RNA granules and plays an important role in brain function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.2), limb E14.5 (RPKM 2.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Caprin2 in Genome Data Viewer
Location:
6 G3; 6 78.62 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148743990..148797756, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148842492..148896257, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene importin 8 Neighboring gene RIKEN cDNA 2610017A05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1717 Neighboring gene predicted gene, 36762 Neighboring gene STARR-seq mESC enhancer starr_17840 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene SIN3-HDAC complex associated factor Neighboring gene RIKEN cDNA 3010003L21 gene Neighboring gene STARR-seq mESC enhancer starr_17845 Neighboring gene STARR-positive B cell enhancer ABC_E4884

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation. Nakazawa K, et al. J Biol Chem, 2020 Oct 30. PMID 32839273, Free PMC Article
  2. FGF signals induce Caprin2 expression in the vertebrate lens. Lorén CE, et al. Differentiation, 2009 Apr. PMID 19275872
  3. Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly. Dash S, et al. Dev Dyn, 2015 Oct. PMID 26177727, Free PMC Article
  4. RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. Shiina N, et al. J Biol Chem, 2010 Jul 30. PMID 20516077, Free PMC Article
  5. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation.
    Title: Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation.
  2. functions in distinct morphological events in mammalian eye development
    Title: Deficiency of the RNA binding protein caprin2 causes lens defects and features of Peters anomaly.
  3. RNG140 has roles in the maintenance of the dendritic structure in the adult vertebrate brain through localizing to a kind of RNA granules that are distinct from RNG105-containing granules
    Title: RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.
  4. The authors have isolated and characterized mouse cytoplasmic activation/proliferation-associated protein-2 (Caprin2), with domains belonging to both the Caprin family and the C1q and tumour necrosis factor (TNF) super-family
    Title: FGF signals induce Caprin2 expression in the vertebrate lens.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA1873

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caprin-2
Names
C1q domain containing 1
C1q domain-containing protein 1
RNA granule protein 140
adiponectin r
cytoplasmic activation/proliferation-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301351.2 → NP_001288280.1  caprin-2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC134542
    UniProtKB/Swiss-Prot
    Q05A80
    Conserved Domains (3) summary
    COG2604
    Location:47 → 177
    COG2604; Uncharacterized conserved protein [Function unknown]
    pfam00386
    Location:683 → 808
    C1q; C1q domain
    pfam12287
    Location:317 → 614
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

  2. NM_001411635.1 → NP_001398564.1  caprin-2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC134542
    UniProtKB/Swiss-Prot
    Q05A80, Q58E31, Q6ZPG7
    UniProtKB/TrEMBL
    E4NKG5

  3. NM_001411636.1 → NP_001398565.1  caprin-2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC134542

  4. NM_001411637.1 → NP_001398566.1  caprin-2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC134542
    Related
    ENSMUSP00000072165.6, ENSMUST00000072324.12

  5. NM_001411638.1 → NP_001398567.1  caprin-2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC134542

  6. NM_001411639.1 → NP_001398568.1  caprin-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC134542
    Related
    ENSMUST00000204942.2

  7. NM_001411640.1 → NP_001398569.1  caprin-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC134542

  8. NM_181541.5 → NP_853519.2  caprin-2 isoform 1

    See identical proteins and their annotated locations for NP_853519.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC134542
    Consensus CDS
    CCDS39720.1
    UniProtKB/Swiss-Prot
    Q05A80, Q58E31, Q6ZPG7
    UniProtKB/TrEMBL
    E4NKG5
    Related
    ENSMUSP00000107195.3, ENSMUST00000111569.9
    Conserved Domains (5) summary
    COG5022
    Location:110 → 377
    COG5022; Myosin heavy chain [General function prediction only]
    pfam00386
    Location:903 → 1028
    C1q; C1q domain
    pfam12287
    Location:528 → 839
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam13870
    Location:45 → 172
    DUF4201; Domain of unknown function (DUF4201)
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    148743990..148797756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507041.5 → XP_006507104.1  caprin-2 isoform X3

    Conserved Domains (5) summary
    COG5022
    Location:110 → 367
    COG5022; Myosin heavy chain [General function prediction only]
    pfam00386
    Location:893 → 1018
    C1q; C1q domain
    pfam12287
    Location:518 → 829
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam13870
    Location:45 → 172
    DUF4201; Domain of unknown function (DUF4201)
    pfam18293
    Location:119 → 224
    Caprin-1_dimer; Caprin-1 dimerization domain

  2. XM_036166093.1 → XP_036021986.1  caprin-2 isoform X6

    Conserved Domains (3) summary
    pfam00386
    Location:562 → 687
    C1q; C1q domain
    pfam12287
    Location:187 → 498
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:2 → 112
    Caprin-1_dimer; Caprin-1 dimerization domain

  3. XM_006507039.5 → XP_006507102.1  caprin-2 isoform X1

    See identical proteins and their annotated locations for XP_006507102.1

    UniProtKB/Swiss-Prot
    Q05A80, Q58E31, Q6ZPG7
    UniProtKB/TrEMBL
    E4NKG5
    Conserved Domains (5) summary
    COG5022
    Location:110 → 377
    COG5022; Myosin heavy chain [General function prediction only]
    pfam00386
    Location:903 → 1028
    C1q; C1q domain
    pfam12287
    Location:528 → 839
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam13870
    Location:45 → 172
    DUF4201; Domain of unknown function (DUF4201)
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  4. XM_030255361.2 → XP_030111221.1  caprin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q05A80, Q58E31, Q6ZPG7
    UniProtKB/TrEMBL
    E4NKG5
    Conserved Domains (5) summary
    COG5022
    Location:110 → 377
    COG5022; Myosin heavy chain [General function prediction only]
    pfam00386
    Location:903 → 1028
    C1q; C1q domain
    pfam12287
    Location:528 → 839
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam13870
    Location:45 → 172
    DUF4201; Domain of unknown function (DUF4201)
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  5. XM_006507040.5 → XP_006507103.1  caprin-2 isoform X2

    Conserved Domains (5) summary
    COG5022
    Location:110 → 377
    COG5022; Myosin heavy chain [General function prediction only]
    pfam00386
    Location:902 → 1027
    C1q; C1q domain
    pfam12287
    Location:528 → 839
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam13870
    Location:45 → 172
    DUF4201; Domain of unknown function (DUF4201)
    pfam18293
    Location:119 → 234
    Caprin-1_dimer; Caprin-1 dimerization domain

  6. XM_036166092.1 → XP_036021985.1  caprin-2 isoform X4

    Conserved Domains (4) summary
    COG5022
    Location:3 → 255
    COG5022; Myosin heavy chain [General function prediction only]
    pfam00386
    Location:781 → 906
    C1q; C1q domain
    pfam12287
    Location:406 → 717
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:2 → 112
    Caprin-1_dimer; Caprin-1 dimerization domain

  7. XM_030255362.2 → XP_030111222.1  caprin-2 isoform X4

    Conserved Domains (4) summary
    COG5022
    Location:3 → 255
    COG5022; Myosin heavy chain [General function prediction only]
    pfam00386
    Location:781 → 906
    C1q; C1q domain
    pfam12287
    Location:406 → 717
    Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
    pfam18293
    Location:2 → 112
    Caprin-1_dimer; Caprin-1 dimerization domain

RNA

  1. XR_004942949.1 RNA Sequence

  2. XR_004942948.1 RNA Sequence

  3. XR_004942950.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05A80.1 GenPept UniProtKB/Swiss-Prot:Q05A80

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