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Klhl42 kelch-like 42 [ Mus musculus (house mouse) ]

Gene ID: 232539, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl42provided by MGI
Official Full Name
kelch-like 42provided by MGI
Primary source
MGI:MGI:2444786
See related
Ensembl:ENSMUSG00000040102 AllianceGenome:MGI:2444786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctb9; Klhdc5; mKIAA1340; A330079N23Rik; C230080I20Rik
Summary
Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in early conceptus; genitourinary system; and olfactory epithelium. Orthologous to human KLHL42 (kelch like family member 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 10.6), adrenal adult (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 77.7 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146990783..147014276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (147090615..147112778)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146991206-146991315 Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene STARR-seq mESC enhancer starr_17814 Neighboring gene MANSC domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_17819 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:147048014-147048197 Neighboring gene predicted gene, 53326 Neighboring gene predicted gene 7571

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. Cummings CM, et al. J Biol Chem, 2009 Apr 24. PMID 19261606, Free PMC Article
  2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch-like protein 42
Names
cullin-3-binding protein 9
kelch domain containing 5
kelch domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081237.2 → NP_001074706.1  kelch-like protein 42 isoform a

    See identical proteins and their annotated locations for NP_001074706.1

    Status: VALIDATED

    Source sequence(s)
    AC153575
    Consensus CDS
    CCDS39716.1
    UniProtKB/Swiss-Prot
    Q6ZPT4, Q8BFQ9
    UniProtKB/TrEMBL
    B2KFS7
    Related
    ENSMUSP00000042558.8, ENSMUST00000036003.8
    Conserved Domains (7) summary
    smart00612
    Location:290 → 332
    Kelch; Kelch domain
    smart00225
    Location:7 → 108
    BTB; Broad-Complex, Tramtrack and Bric a brac
    PHA03098
    Location:198 → 485
    PHA03098; kelch-like protein; Provisional
    cd14735
    Location:117 → 162
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:232 → 275
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:232 → 276
    Kelch_1; Kelch motif
    cl02518
    Location:7 → 108
    BTB; BTB/POZ domain

  2. NM_001418232.1 → NP_001405161.1  kelch-like protein 42 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153575

  3. NM_001418233.1 → NP_001405162.1  kelch-like protein 42 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153575

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    146990783..147014276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507038.5 → XP_006507101.1  kelch-like protein 42 isoform X1

    See identical proteins and their annotated locations for XP_006507101.1

    Conserved Domains (4) summary
    sd00038
    Location:179 → 223
    Kelch; KELCH repeat [structural motif]
    cd18319
    Location:4 → 101
    BTB_POZ_KLHL42; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42)
    cd18478
    Location:113 → 225
    BACK_KLHL42_KLHDC5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42)
    pfam01344
    Location:232 → 276
    Kelch_1; Kelch motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFQ9.1 GenPept UniProtKB/Swiss-Prot:Q8BFQ9

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