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Stk38l serine/threonine kinase 38 like [ Mus musculus (house mouse) ]

Gene ID: 232533, updated on 16-Apr-2024

Summary

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Official Symbol
Stk38lprovided by MGI
Official Full Name
serine/threonine kinase 38 likeprovided by MGI
Primary source
MGI:MGI:1922250
See related
Ensembl:ENSMUSG00000001630 AllianceGenome:MGI:1922250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr2; Ndr54; 4930473A22Rik
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in regulation of cellular component organization. Located in actin cytoskeleton and cytoplasm. Orthologous to human STK38L (serine/threonine kinase 38 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.6), frontal lobe adult (RPKM 3.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 77.7 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146626428..146680312)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146724930..146778814)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930479D17 gene Neighboring gene mediator complex subunit 21 Neighboring gene predicted pseudogene 6654 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146623095-146623296 Neighboring gene STARR-positive B cell enhancer ABC_E6504 Neighboring gene STARR-seq mESC enhancer starr_17805 Neighboring gene STARR-positive B cell enhancer ABC_E1332 Neighboring gene STARR-seq mESC enhancer starr_17807 Neighboring gene STARR-seq mESC enhancer starr_17808 Neighboring gene STARR-seq mESC enhancer starr_17809 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene basic helix-loop-helix ARNT like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation. Wang S, et al. Cell Rep, 2022 Nov 22. PMID 36417850
  2. NDR functions as a physiological YAP1 kinase in the intestinal epithelium. Zhang L, et al. Curr Biol, 2015 Feb 2. PMID 25601544, Free PMC Article
  3. The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. Rehberg K, et al. J Neurosci, 2014 Apr 9. PMID 24719112, Free PMC Article
  4. Neuronal functions of the novel serine/threonine kinase Ndr2. Stork O, et al. J Biol Chem, 2004 Oct 29. PMID 15308672
  5. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. Stegert MR, et al. J Biol Chem, 2004 May 28. PMID 15037617

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
    Title: LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
  2. NDR1/2 functions as a physiological YAP1 kinase in the intestinal epithelium.
    Title: NDR functions as a physiological YAP1 kinase in the intestinal epithelium.
  3. Ndr2 is an interesting candidate gene for the regulation of structural processes in differentiating and mature neuronal cells.
    Title: Neuronal functions of the novel serine/threonine kinase Ndr2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • B230328I19

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular component organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 38-like
Names
nuclear Dbf2-related kinase 2
NP_001333595.1
NP_766322.1
XP_006507090.2
XP_006507092.1
XP_006507094.1
XP_006507095.1
XP_017177049.1
XP_030111217.1
XP_030111218.1
XP_030111220.1
XP_036021983.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346666.1 → NP_001333595.1  serine/threonine-protein kinase 38-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which as a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK045971, AY223819, BE946381, BY434134, CJ082246
    UniProtKB/Swiss-Prot
    Q7TSE6
    Conserved Domains (1) summary
    cl21453
    Location:1 → 335
    PKc_like; Protein Kinases, catalytic domain

  2. NM_172734.3 → NP_766322.1  serine/threonine-protein kinase 38-like isoform 1

    See identical proteins and their annotated locations for NP_766322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC164631, AK052288, CJ082246
    Consensus CDS
    CCDS39712.1
    UniProtKB/Swiss-Prot
    B2KFR4, Q6P6K6, Q7TSE6, Q8BWK4
    Related
    ENSMUSP00000001675.8, ENSMUST00000001675.14
    Conserved Domains (2) summary
    smart00220
    Location:90 → 383
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05627
    Location:87 → 452
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    146626428..146680312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507027.2 → XP_006507090.2  serine/threonine-protein kinase 38-like isoform X1

    See identical proteins and their annotated locations for XP_006507090.2

    UniProtKB/Swiss-Prot
    Q7TSE6
    Related
    ENSMUSP00000107271.2, ENSMUST00000111644.2
    Conserved Domains (1) summary
    cd05627
    Location:87 → 459
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  2. XM_036166090.1 → XP_036021983.1  serine/threonine-protein kinase 38-like isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:87 → 391
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006507032.4 → XP_006507095.1  serine/threonine-protein kinase 38-like isoform X7

    See identical proteins and their annotated locations for XP_006507095.1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 342
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030255358.2 → XP_030111218.1  serine/threonine-protein kinase 38-like isoform X6

    Conserved Domains (1) summary
    cd05627
    Location:35 → 400
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  5. XM_006507031.3 → XP_006507094.1  serine/threonine-protein kinase 38-like isoform X5

    See identical proteins and their annotated locations for XP_006507094.1

    Conserved Domains (1) summary
    cd05627
    Location:35 → 407
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  6. XM_017321560.3 → XP_017177049.1  serine/threonine-protein kinase 38-like isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:1 → 335
    PKc_like; Protein Kinases, catalytic domain

  7. XM_030255360.2 → XP_030111220.1  serine/threonine-protein kinase 38-like isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:1 → 342
    PKc_like; Protein Kinases, catalytic domain

  8. XM_030255357.2 → XP_030111217.1  serine/threonine-protein kinase 38-like isoform X4

    Conserved Domains (1) summary
    cd05627
    Location:93 → 458
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

  9. XM_006507029.5 → XP_006507092.1  serine/threonine-protein kinase 38-like isoform X3

    See identical proteins and their annotated locations for XP_006507092.1

    Conserved Domains (1) summary
    cd05627
    Location:93 → 465
    STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

RNA

  1. XR_004942946.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSE6.2 GenPept UniProtKB/Swiss-Prot:Q7TSE6

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