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Rerg RAS-like, estrogen-regulated, growth-inhibitor [ Mus musculus (house mouse) ]

Gene ID: 232441, updated on 11-Apr-2024

Summary

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Official Symbol
Rergprovided by MGI
Official Full Name
RAS-like, estrogen-regulated, growth-inhibitorprovided by MGI
Primary source
MGI:MGI:2665139
See related
Ensembl:ENSMUSG00000030222 AllianceGenome:MGI:2665139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in several processes, including Ras protein signal transduction; negative regulation of cell growth; and negative regulation of cell population proliferation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in bladder; gonad; limb; and sensory organ. Orthologous to human RERG (RAS like estrogen regulated growth inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 26.0), bladder adult (RPKM 12.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G1; 6 66.73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137031822..137147494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137054825..137170496, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9680 Neighboring gene STARR-positive B cell enhancer mm9_chr6:136929021-136929322 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene predicted gene, 30055 Neighboring gene STARR-seq mESC enhancer starr_17616 Neighboring gene STARR-seq mESC enhancer starr_17617 Neighboring gene predicted gene, 52923 Neighboring gene predicted gene, 38914 Neighboring gene STARR-positive B cell enhancer mm9_chr6:137140638-137140939 Neighboring gene STARR-seq mESC enhancer starr_17624 Neighboring gene protein tyrosine phosphatase receptor type O Neighboring gene predicted gene, 52924 Neighboring gene STARR-seq mESC enhancer starr_17627 Neighboring gene epidermal growth factor receptor pathway substrate 8 Neighboring gene STARR-seq mESC enhancer starr_17628

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Nef S, et al. Dev Biol, 2005 Nov 15. PMID 16214126
  2. The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution. Li H, et al. Development, 2019 Jun 17. PMID 31118233, Free PMC Article
  3. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Bouma GJ, et al. Biol Reprod, 2010 Feb. PMID 19864314, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related and estrogen-regulated growth inhibitor
NP_001157684.1
NP_001157686.1
NP_871788.1
XP_036021981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164212.1 → NP_001157684.1  ras-related and estrogen-regulated growth inhibitor isoform a

    See identical proteins and their annotated locations for NP_001157684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 each encode isoform a.
    Source sequence(s)
    AC122303, AC144767, AK133734
    Consensus CDS
    CCDS20663.1
    UniProtKB/Swiss-Prot
    Q8R367
    Related
    ENSMUSP00000113105.2, ENSMUST00000117919.8
    Conserved Domains (1) summary
    cd04146
    Location:8 → 169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

  2. NM_001164214.1 → NP_001157686.1  ras-related and estrogen-regulated growth inhibitor isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC122303, AC144767, AK133734
    Consensus CDS
    CCDS51942.1
    UniProtKB/TrEMBL
    E9PUF8
    Related
    ENSMUSP00000113702.2, ENSMUST00000119610.4
    Conserved Domains (1) summary
    cl21455
    Location:8 → 150
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_181988.2 → NP_871788.1  ras-related and estrogen-regulated growth inhibitor isoform a

    See identical proteins and their annotated locations for NP_871788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 each encode isoform a.
    Source sequence(s)
    AC122303, AC144767, AK133734
    Consensus CDS
    CCDS20663.1
    UniProtKB/Swiss-Prot
    Q8R367
    Related
    ENSMUSP00000032347.5, ENSMUST00000032347.11
    Conserved Domains (1) summary
    cd04146
    Location:8 → 169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    137031822..137147494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166088.1 → XP_036021981.1  ras-related and estrogen-regulated growth inhibitor isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 114
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R367.1 GenPept UniProtKB/Swiss-Prot:Q8R367

Gene LinkOut

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