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Klrh1 killer cell lectin-like receptor subfamily H, member 1 [ Mus musculus (house mouse) ]

Gene ID: 232415, updated on 11-Apr-2024

Summary

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Official Symbol
Klrh1provided by MGI
Official Full Name
killer cell lectin-like receptor subfamily H, member 1provided by MGI
Primary source
MGI:MGI:2685002
See related
Ensembl:ENSMUSG00000071158 AllianceGenome:MGI:2685002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm156
Summary
Predicted to enable (1->3)-beta-D-glucan binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including phagocytosis, recognition; positive regulation of cytokine production involved in inflammatory response; and response to fungus. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
6 F3; 6 63.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129743531..129761233, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129766568..129784270, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor family I member 2 Neighboring gene predicted gene, 57684 Neighboring gene STARR-seq mESC enhancer starr_17482 Neighboring gene killer cell lectin-like receptor, subfamily A, member 17 Neighboring gene predicted gene, 23977 Neighboring gene killer cell lectin-like receptor, subfamily A, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (1->3)-beta-D-glucan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokine production involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
killer cell lectin-like receptor subfamily H, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014997.2 → NP_001014997.1  killer cell lectin-like receptor subfamily H, member 1 isoform 1

    See identical proteins and their annotated locations for NP_001014997.1

    Status: VALIDATED

    Source sequence(s)
    AB121775, AK138706
    Consensus CDS
    CCDS20595.1
    UniProtKB/TrEMBL
    Q58A37
    Related
    ENSMUSP00000093058.3, ENSMUST00000095409.3
    Conserved Domains (2) summary
    cd03593
    Location:100 → 216
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:31 → 114
    Ly49; Ly49-like protein, N-terminal region

  2. NM_001356340.1 → NP_001343269.1  killer cell lectin-like receptor subfamily H, member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK138706
    Consensus CDS
    CCDS90128.1
    UniProtKB/TrEMBL
    Q3UU75
    Related
    ENSMUSP00000113766.2, ENSMUST00000118532.8
    Conserved Domains (2) summary
    cd03593
    Location:100 → 171
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:31 → 114
    Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129743531..129761233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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