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Ankrd26 ankyrin repeat domain 26 [ Mus musculus (house mouse) ]

Gene ID: 232339, updated on 8-Feb-2024

Summary

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Official Symbol
Ankrd26provided by MGI
Official Full Name
ankyrin repeat domain 26provided by MGI
Primary source
MGI:MGI:1917887
See related
Ensembl:ENSMUSG00000007827 AllianceGenome:MGI:1917887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1074; 5730521P14Rik
Summary
Involved in negative regulation of fat cell differentiation. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of organ growth; and negative regulation of signal transduction. Located in actin cytoskeleton. Used to study obesity. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including ANKRD26 (ankyrin repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 3.8) and 19 other tissues See more
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Genomic context

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Location:
6 F1; 6 55.86 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118478261..118539244, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118501300..118562280, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 248 pseudogene Neighboring gene zinc finger protein 9 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene predicted gene, 38887 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity. Raciti GA, et al. Sci Rep, 2017 Mar 7. PMID 28266632, Free PMC Article
  2. A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice. Acs P, et al. Brain Struct Funct, 2015. PMID 24633808, Free PMC Article
  3. Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice. Raciti GA, et al. Diabetologia, 2011 Nov. PMID 21842266, Free PMC Article
  4. Centriole signaling restricts hepatocyte ploidy to maintain liver integrity. Sladky VC, et al. Genes Dev, 2022 Aug 18. PMID 35981754, Free PMC Article
  5. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. Fei Z, et al. J Biol Chem, 2011 Aug 5. PMID 21669876, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the methylation of specific CpGs at the Ankrd26 promoter occurs in mice during HFD treatment and causes the down-regulation of Ankrd26 expression, at least in part, by impairing p300 binding to its promoter. We propose that the epigenetic silencing of the Ankrd26 gene contributes to VAT inflammation following unhealthy dieting.
    Title: Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity.
  2. Deletion of the C-terminus of the protein encoded by Ankrd26 leads to changes in primary cilia in the brain, resulting in the disruption of the function of the melanocortin pathway and the HPA axis and leading to excessive food intake and obesity.
    Title: A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice.
  3. Data indicate that Ankrd26 is involved in regulation of food intake and in regulation of insulin/insulin receptor signaling in white adipose tissue; partial inactivation of Ankrd26 leads to obesity and, thus, to diabetes type 2.
    Title: Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice.
  4. conclude that Ankrd26 gene disruption promotes adipocyte differentiation at both the progenitor commitment and differentiation steps and that ERK activation plays a role in this process
    Title: Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts.
  5. obesity and gigantism may be caused by a disruption of the Ankrd26 gene
    Title: A model for obesity and gigantism due to disruption of the Ankrd26 gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081112.2 → NP_001074581.1  ankyrin repeat domain-containing protein 26

    Status: VALIDATED

    Source sequence(s)
    AC036121, AC140192
    Consensus CDS
    CCDS39609.1
    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    UniProtKB/TrEMBL
    D3Z482
    Related
    ENSMUSP00000108449.2, ENSMUST00000112830.3
    Conserved Domains (8) summary
    COG1340
    Location:1197 → 1457
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00204
    Location:75 → 200
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:1495 → 1602
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:51 → 101
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:886 → 1189
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:82 → 111
    ANK; ANK repeat [structural motif]
    cl21509
    Location:1195 → 1329
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    118478261..118539244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506023.4 → XP_006506086.1  ankyrin repeat domain-containing protein 26 isoform X2

    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    Conserved Domains (6) summary
    PLN03192
    Location:54 → 277
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG1196
    Location:690 → 1521
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:82 → 111
    ANK; ANK repeat [structural motif]
    pfam12001
    Location:1462 → 1569
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:853 → 1156
    CCDC144C; CCDC144C protein coiled-coil region

  2. XM_006506022.4 → XP_006506085.1  ankyrin repeat domain-containing protein 26 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    Conserved Domains (6) summary
    PLN03192
    Location:54 → 277
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG1196
    Location:728 → 1559
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:82 → 111
    ANK; ANK repeat [structural motif]
    pfam12001
    Location:1500 → 1607
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:891 → 1194
    CCDC144C; CCDC144C protein coiled-coil region

  3. XM_036166065.1 → XP_036021958.1  ankyrin repeat domain-containing protein 26 isoform X6

    Conserved Domains (3) summary
    COG1196
    Location:305 → 1136
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:1077 → 1184
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:468 → 772
    CCDC144C; CCDC144C protein coiled-coil region

  4. XM_036166064.1 → XP_036021957.1  ankyrin repeat domain-containing protein 26 isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:338 → 1169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:1110 → 1217
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:501 → 805
    CCDC144C; CCDC144C protein coiled-coil region

  5. XM_030255354.2 → XP_030111214.1  ankyrin repeat domain-containing protein 26 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:343 → 1174
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:1115 → 1222
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:506 → 809
    CCDC144C; CCDC144C protein coiled-coil region

  6. XM_006506025.4 → XP_006506088.1  ankyrin repeat domain-containing protein 26 isoform X7

    Conserved Domains (3) summary
    COG1196
    Location:240 → 1071
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:1012 → 1119
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:403 → 706
    CCDC144C; CCDC144C protein coiled-coil region

  7. XM_006506024.4 → XP_006506087.1  ankyrin repeat domain-containing protein 26 isoform X3

    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    Conserved Domains (6) summary
    PLN03192
    Location:54 → 277
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG1196
    Location:660 → 930
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:1104 → 1300
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    sd00045
    Location:82 → 111
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:85 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:891 → 1194
    CCDC144C; CCDC144C protein coiled-coil region

RNA

  1. XR_001785122.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811D2.2 GenPept UniProtKB/Swiss-Prot:Q811D2

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