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Vgll4 vestigial like family member 4 [ Mus musculus (house mouse) ]

Gene ID: 232334, updated on 4-May-2024

Summary

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Official Symbol
Vgll4provided by MGI
Official Full Name
vestigial like family member 4provided by MGI
Primary source
MGI:MGI:2652840
See related
Ensembl:ENSMUSG00000030315 AllianceGenome:MGI:2652840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VGL-4
Summary
Predicted to enable transcription coactivator binding activity. Involved in several processes, including negative regulation of cardiac muscle cell proliferation; negative regulation of hippo signaling; and positive regulation of cellular protein catabolic process. Located in nucleus. Is expressed in lung; submandibular gland primordium; tooth; and vibrissa. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 23.7), lung adult (RPKM 17.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 53.07 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114836850..114946932, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114860621..114970007, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene autophagy related 7 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17064 Neighboring gene STARR-positive B cell enhancer ABC_E11331 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114824988-114825171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114825181-114825290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114843851-114843960 Neighboring gene STARR-seq mESC enhancer starr_17069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114870691-114870844 Neighboring gene STARR-positive B cell enhancer ABC_E4855 Neighboring gene STARR-positive B cell enhancer mm9_chr6:114872780-114873081 Neighboring gene STARR-positive B cell enhancer ABC_E4856 Neighboring gene predicted gene, 38876 Neighboring gene STARR-seq mESC enhancer starr_17074 Neighboring gene STARR-seq mESC enhancer starr_17075 Neighboring gene STARR-positive B cell enhancer ABC_E6470 Neighboring gene predicted gene, 52944 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Critical role of VGLL4 in the regulation of chronic normobaric hypoxia-induced pulmonary hypertension in mice. Tian Q, et al. FASEB J, 2021 Aug. PMID 34314061
  2. Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion. Xie W, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30119884
  3. Dual function of VGLL4 in muscle regeneration. Feng X, et al. EMBO J, 2019 Sep 2. PMID 31328806, Free PMC Article
  4. The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex. Zhang W, et al. J Biol Chem, 2018 Nov 2. PMID 30209132, Free PMC Article
  5. Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers. Nezhad FY, et al. Transgenic Res, 2022 Apr. PMID 34984591, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
    Title: Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
  2. Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development.
    Title: Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development.
  3. Critical role of VGLL4 in the regulation of chronic normobaric hypoxia-induced pulmonary hypertension in mice.
    Title: Critical role of VGLL4 in the regulation of chronic normobaric hypoxia-induced pulmonary hypertension in mice.
  4. Studies identified VGLL4 as a novel activator in regulating muscle regeneration at the differentiation stage, which provides new insights into the YAP-independent role of VGLL4 in skeletal muscle regeneration.
    Title: Dual function of VGLL4 in muscle regeneration.
  5. VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CtBP2, and this TEAD4-VGLL4-CtBP2 ternary complex dynamically existed at the early stage of adipogenesis.
    Title: The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex.
  6. Results revealed an essential role of VGLL4 in heart valve morphogenesis via regulating valvar interstitial cells proliferation and apoptosis. Furthermore, its deletion resulted in progressive valve disease. These findings suggest that mutations in VGLL4 may underlie human congenital heart valve dysplasia.
    Title: VGLL4 plays a critical role in heart valve development and homeostasis.
  7. Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma in a mouse model with G2/M phase arrest and apoptosis promotion.
    Title: Adenovirus armed with VGLL4 selectively kills hepatocellular carcinoma with G2/M phase arrest and apoptosis promotion.
  8. VGLL4 inhibits cardiomyocyte proliferation by inhibiting TEAD1-YAP interaction and by targeting TEAD1 for degradation.
    Title: Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth.
  9. Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes
    Title: Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC54805

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription cofactor vestigial-like protein 4
Names
vestigial like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356371.2 → NP_001343300.1  transcription cofactor vestigial-like protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149276
    UniProtKB/TrEMBL
    D3Z130, Q3TQI9
    Related
    ENSMUSP00000123139.2, ENSMUST00000147639.8
    Conserved Domains (2) summary
    smart00711
    Location:225 → 240
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:8 → 215
    VGLL4; Transcription cofactor vestigial-like protein 4

  2. NM_001411599.1 → NP_001398528.1  transcription cofactor vestigial-like protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149276
    UniProtKB/TrEMBL
    Q3TQI9

  3. NM_001411600.1 → NP_001398529.1  transcription cofactor vestigial-like protein 4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC149276

  4. NM_001411601.1 → NP_001398530.1  transcription cofactor vestigial-like protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC149276
    UniProtKB/TrEMBL
    Q3TSJ2

  5. NM_001411602.1 → NP_001398531.1  transcription cofactor vestigial-like protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC149276

  6. NM_177683.4 → NP_808351.1  transcription cofactor vestigial-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_808351.1

    Status: VALIDATED

    Source sequence(s)
    AC149276
    Consensus CDS
    CCDS20436.1
    UniProtKB/Swiss-Prot
    Q80V24
    Related
    ENSMUSP00000032459.8, ENSMUST00000032459.14
    Conserved Domains (2) summary
    smart00711
    Location:231 → 246
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:14 → 220
    VGLL4; Transcription cofactor vestigial-like protein 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    114836850..114946932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166060.1 → XP_036021953.1  transcription cofactor vestigial-like protein 4 isoform X2

    Conserved Domains (2) summary
    smart00711
    Location:194 → 209
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:8 → 184
    VGLL4; Transcription cofactor vestigial-like protein 4

  2. XM_006506012.3 → XP_006506075.1  transcription cofactor vestigial-like protein 4 isoform X2

    Conserved Domains (2) summary
    smart00711
    Location:194 → 209
    TDU; Short repeats in human TONDU, fly vestigial and other proteins
    pfam15245
    Location:8 → 184
    VGLL4; Transcription cofactor vestigial-like protein 4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80V24.1 GenPept UniProtKB/Swiss-Prot:Q80V24

Gene LinkOut

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