Tmf1 TATA element modulatory factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmf1provided by MGI
Official Full Name: TATA element modulatory factor 1provided by MGI
Primary source: MGI:MGI:2684999
See related: Ensembl:ENSMUSG00000030059 AllianceGenome:MGI:2684999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm153; Tmf1`; 7030402D04Rik
Summary: Predicted to enable androgen receptor binding activity and nuclear receptor coactivator activity. Involved in regulation of proteasomal protein catabolic process. Acts upstream of or within several processes, including Leydig cell differentiation; regulation of gene expression; and spermatid development. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in mandible and maxilla. Orthologous to human TMF1 (TATA element modulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 8.6), cerebellum adult (RPKM 3.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D3; 6 44.89 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (97128911..97156107, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (97151950..97179151, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMF1 is upregulated by insulin and is required for a sustained glucose homeostasis.
Title: TMF1 is upregulated by insulin and is required for a sustained glucose homeostasis.
The microtubule interacting domain (MIT) domain in TMF, along with microtubule integrity, are required for stable association of TMF with the Golgi apparatus.
Title: TMF/ARA160 Governs the Dynamic Spatial Orientation of the Golgi Apparatus during Sperm Development.
Altered mucus secretion in TMF(-/-) mouse colons is accompanied by a reprogrammed intestinal microbiota, leading to a transmissible reduced sensitivity to induced colitis.
Title: Reprogrammed and transmissible intestinal microbiota confer diminished susceptibility to induced colitis in TMF-/- mice.
Data from knockout mice suggest that TMF/ARA160 participates in control of serum testosterone levels in males, and its absence results in major testicular and epididymal defects and abnormal spermatogenesis and Leydig cell proliferation.
Title: Testosterone deficiency accompanied by testicular and epididymal abnormalities in TMF(-/-) mice.
absence of TMF/ARA160 renders the colonic mucus refractory to bacterial colonization and the large intestine less susceptible to the onset of colitis.
Title: Loss of TMF/ARA160 protein renders colonic mucus refractory to bacterial colonization and diminishes intestinal susceptibility to acute colitis.
TMF/ARA160 is a key regulator which is essential for the onset of key events in the differentiation and maturation of mammalian sperm and whose absence severely compromises their ability to fertilize ova.
Title: TMF/ARA160: A key regulator of sperm development.
TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3
Title: TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Leydig cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of testosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid nucleus differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TATA element modulatory factor

Names: TMF; androgen receptor coactivator 160 kDa protein; androgen receptor-associated protein of 160 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081111.2 → NP_001074580.1 TATA element modulatory factor

See identical proteins and their annotated locations for NP_001074580.1

Status: VALIDATED

Source sequence(s)

AC155724, AK144898, BE627586, BQ561256, BQ561257, CN456538

Consensus CDS

CCDS39575.1

UniProtKB/Swiss-Prot

B9EKI3, E9QPJ3, Q3UMH8, Q3UMR3

Related

ENSMUSP00000093325.4, ENSMUST00000095664.6

Conserved Domains (3) summary

pfam00261
Location:600 → 800

Tropomyosin; Tropomyosin

pfam12325
Location:974 → 1085

TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

pfam12329
Location:540 → 613

TMF_DNA_bd; TATA element modulatory factor 1 DNA binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

97128911..97156107 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255349.2 → XP_030111209.1 TATA element modulatory factor isoform X1

Conserved Domains (2) summary

COG1196
Location:232 → 869

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12325
Location:754 → 865

TMF_TATA_bd; TATA element modulatory factor 1 TATA binding