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Arhgap25 Rho GTPase activating protein 25 [ Mus musculus (house mouse) ]

Gene ID: 232201, updated on 11-Apr-2024

Summary

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Official Symbol
Arhgap25provided by MGI
Official Full Name
Rho GTPase activating protein 25provided by MGI
Primary source
MGI:MGI:2443687
See related
Ensembl:ENSMUSG00000030047 AllianceGenome:MGI:2443687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A130039I20Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of small GTPase mediated signal transduction; and phagocytosis, engulfment. Predicted to be active in phagocytic cup. Is expressed in brain; pharyngo-tympanic tube; and vibrissa. Orthologous to human ARHGAP25 (Rho GTPase activating protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 4.7), thymus adult (RPKM 2.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 38.01 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87435526..87510241, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87458544..87533261, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10 Neighboring gene STARR-positive B cell enhancer ABC_E861 Neighboring gene STARR-positive B cell enhancer ABC_E4843 Neighboring gene STARR-positive B cell enhancer ABC_E3663 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:87492045-87492293 Neighboring gene STARR-seq mESC enhancer starr_16556 Neighboring gene STARR-positive B cell enhancer ABC_E680 Neighboring gene STARR-seq mESC enhancer starr_16558 Neighboring gene prokineticin receptor 1 Neighboring gene predicted gene, 34222 Neighboring gene predicted gene, 34312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice. Czárán D, et al. Front Immunol, 2023. PMID 37234175, Free PMC Article
  2. Arhgap25 Deficiency Leads to Decreased Numbers of Peripheral Blood B Cells and Defective Germinal Center Reactions. Lindner SE, et al. Immunohorizons, 2020 May 20. PMID 32434881, Free PMC Article
  3. Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice. Csépányi-Kömi R, et al. J Immunol, 2016 Oct 1. PMID 27566826
  4. Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization. Wang LD, et al. Blood, 2016 Sep 15. PMID 27365422, Free PMC Article
  5. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. Katoh M, et al. Int J Mol Med, 2004 Aug. PMID 15254788

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice.
    Title: Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice.
  2. Arhgap25 Deficiency Leads to Decreased Numbers of Peripheral Blood B Cells and Defective Germinal Center Reactions.
    Title: Arhgap25 Deficiency Leads to Decreased Numbers of Peripheral Blood B Cells and Defective Germinal Center Reactions.
  3. Using Arhgap25-deficient mice, it identified ARHGAP25 as a relevant negative regulator of leukocyte transendothelial migration.
    Title: Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in phagocytic cup IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 25
Names
rho-type GTPase-activating protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037727.2 → NP_001032816.1  rho GTPase-activating protein 25 isoform a

    See identical proteins and their annotated locations for NP_001032816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK037710, AK137526, AK159941
    Consensus CDS
    CCDS20321.1
    UniProtKB/Swiss-Prot
    B2RS69, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98, Q8BYW1
    UniProtKB/TrEMBL
    B9EI26
    Related
    ENSMUSP00000109267.3, ENSMUST00000113637.9
    Conserved Domains (3) summary
    cd04390
    Location:156 → 354
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:45 → 157
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:47 → 149
    PH; PH domain

  2. NM_001286610.1 → NP_001273539.1  rho GTPase-activating protein 25 isoform c

    See identical proteins and their annotated locations for NP_001273539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK137526, AK159941
    Consensus CDS
    CCDS71790.1
    UniProtKB/TrEMBL
    B9EI26
    Related
    ENSMUSP00000068964.7, ENSMUST00000071024.7
    Conserved Domains (3) summary
    cd04390
    Location:67 → 265
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:3 → 60
    PH; PH domain
    cl17171
    Location:1 → 68
    PH-like; Pleckstrin homology-like domain

  3. NM_175476.4 → NP_780685.2  rho GTPase-activating protein 25 isoform b

    See identical proteins and their annotated locations for NP_780685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform b, which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK137444, AK137526, CJ145934
    Consensus CDS
    CCDS20322.1
    UniProtKB/TrEMBL
    B9EI26
    Related
    ENSMUSP00000098758.3, ENSMUST00000101197.9
    Conserved Domains (3) summary
    cd04390
    Location:130 → 328
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:19 → 131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:21 → 123
    PH; PH domain

RNA

  1. NR_104483.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate terminal 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK137526, CJ145934
    Related
    ENSMUST00000145128.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87435526..87510241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166049.1 → XP_036021942.1  rho GTPase-activating protein 25 isoform X2

    Conserved Domains (2) summary
    cd04390
    Location:130 → 328
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    cd13263
    Location:19 → 131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain

  2. XM_017321531.2 → XP_017177020.1  rho GTPase-activating protein 25 isoform X1

    UniProtKB/TrEMBL
    B9EI26
    Conserved Domains (4) summary
    COG1196
    Location:505 → 606
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:117 → 315
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam05667
    Location:381 → 602
    DUF812; Protein of unknown function (DUF812)
    cl17171
    Location:45 → 122
    PH-like; Pleckstrin homology-like domain

  3. XM_006505980.4 → XP_006506043.1  rho GTPase-activating protein 25 isoform X3

    Conserved Domains (3) summary
    COG1196
    Location:426 → 527
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:38 → 236
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam05667
    Location:302 → 523
    DUF812; Protein of unknown function (DUF812)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYW1.2 GenPept UniProtKB/Swiss-Prot:Q8BYW1

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