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PRRC2C proline rich coiled-coil 2C [ Homo sapiens (human) ]

Gene ID: 23215, updated on 7-Apr-2024

Summary

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Official Symbol
PRRC2Cprovided by HGNC
Official Full Name
proline rich coiled-coil 2Cprovided by HGNC
Primary source
HGNC:HGNC:24903
See related
Ensembl:ENSG00000117523 MIM:617373; AllianceGenome:HGNC:24903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XTP2; BAT2D1; BAT2L2; BAT2-iso
Summary
Enables protein C-terminus binding activity. Involved in stress granule assembly. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 24.0), lymph node (RPKM 17.9) and 25 other tissues See more
Orthologs
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Genomic context

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See PRRC2C in Genome Data Viewer
Location:
1q24.3
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (171485530..171593511)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (170841969..170949975)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171454669..171562650)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CYCS pseudogene 53 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:171454474-171455222 Neighboring gene RNA, 7SL, cytoplasmic 425, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:171475977-171476512 Neighboring gene U6 spliceosomal RNA Neighboring gene ReSE screen-validated silencer GRCh37_chr1:171489309-171489479 Neighboring gene myocilin opposite strand Neighboring gene MPRA-validated peak453 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:171613996-171614502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:171614503-171615009 Neighboring gene myocilin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer. Huang WC, et al. DNA Cell Biol, 2002 Oct. PMID 12443540
  2. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. Sun NN, et al. Toxicol Ind Health, 2003 Oct. PMID 15747776
  3. The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. Miele A, et al. J Cell Biochem, 2007 Sep 1. PMID 17577209
  4. Proteome analysis of the HIV-1 Gag interactome. Engeland CE, et al. Virology, 2014 Jul. PMID 25010285
  5. The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism. Sanderson MR, et al. J Biol Chem, 2021 Aug. PMID 34265304, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. The KIAA1096 gene is located at 1q23-24 with no overexpression or amplification in normal urothelium, but was significantly upregulated in 30% of tumors.
    Title: KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer.
  3. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h
    Title: Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated proline-rich coiled-coil 2C (PRRC2C) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with proline-rich coiled-coil 2C (PRRC2C, BAT2L2) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
protein PRRC2C
Names
BAT2 domain containing 1
BAT2 domain-containing protein 1
HBV X-transactivated gene 2 protein
HBV XAg-transactivated protein 2
HBxAg transactivated protein 2
HLA-B-associated transcript 2-like 2
proline-rich and coiled-coil-containing protein 2C
protein BAT2-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387844.1 → NP_001374773.1  protein PRRC2C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL021579, AL049762, Z98750
    Consensus CDS
    CCDS91104.1
    Related
    ENSP00000495867.2, ENST00000647382.2
    Conserved Domains (2) summary
    PTZ00449
    Location:931 → 1309
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  2. NM_015172.4 → NP_055987.2  protein PRRC2C isoform 1

    See identical proteins and their annotated locations for NP_055987.2

    Status: VALIDATED

    Source sequence(s)
    AF488829, AL133635, AL162004, BC001260, CB158511
    Consensus CDS
    CCDS1296.2
    UniProtKB/Swiss-Prot
    Q9Y520
    Related
    ENSP00000343629.4, ENST00000338920.8
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 160
    BAT2_N; BAT2 N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    171485530..171593511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245020.3 → XP_005245077.1  protein PRRC2C isoform X6

    Conserved Domains (2) summary
    pfam09606
    Location:2258 → 2642
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  2. XM_005245015.3 → XP_005245072.1  protein PRRC2C isoform X1

    Conserved Domains (2) summary
    pfam09606
    Location:2258 → 2642
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  3. XM_005245025.3 → XP_005245082.1  protein PRRC2C isoform X10

    Conserved Domains (2) summary
    pfam09606
    Location:2258 → 2642
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  4. XM_005245023.3 → XP_005245080.1  protein PRRC2C isoform X8

    Conserved Domains (2) summary
    pfam09606
    Location:2258 → 2642
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  5. XM_005245028.3 → XP_005245085.1  protein PRRC2C isoform X13

    Conserved Domains (2) summary
    pfam09606
    Location:2258 → 2642
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  6. XM_005245027.3 → XP_005245084.1  protein PRRC2C isoform X12

    Conserved Domains (2) summary
    pfam09606
    Location:2258 → 2642
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  7. XM_017000761.2 → XP_016856250.1  protein PRRC2C isoform X7

  8. XM_005245026.3 → XP_005245083.1  protein PRRC2C isoform X11

    Conserved Domains (1) summary
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  9. XM_005245024.3 → XP_005245081.1  protein PRRC2C isoform X9

    UniProtKB/TrEMBL
    E7EPN9
    Related
    ENSP00000356716.3, ENST00000367742.7
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  10. XM_047415746.1 → XP_047271702.1  protein PRRC2C isoform X15

  11. XM_005245029.3 → XP_005245086.1  protein PRRC2C isoform X14

    Conserved Domains (1) summary
    pfam07001
    Location:1 → 162
    BAT2_N; BAT2 N-terminus

  12. XM_005245018.4 → XP_005245075.1  protein PRRC2C isoform X3

    Conserved Domains (2) summary
    pfam09606
    Location:2253 → 2637
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 157
    BAT2_N; BAT2 N-terminus

  13. XM_005245016.6 → XP_005245073.1  protein PRRC2C isoform X2

    Conserved Domains (2) summary
    pfam09606
    Location:2256 → 2640
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 160
    BAT2_N; BAT2 N-terminus

  14. XM_006711238.5 → XP_006711301.1  protein PRRC2C isoform X4

    See identical proteins and their annotated locations for XP_006711301.1

    UniProtKB/Swiss-Prot
    Q05DM8, Q49A39, Q6PD54, Q9H2N2, Q9HA05, Q9NSM8, Q9NXL3, Q9UF29, Q9UPQ6, Q9Y520
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 160
    BAT2_N; BAT2 N-terminus

  15. XM_017000760.3 → XP_016856249.1  protein PRRC2C isoform X5

  16. XM_047415747.1 → XP_047271703.1  protein PRRC2C isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    170841969..170949975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335383.1 → XP_054191358.1  protein PRRC2C isoform X6

  2. XM_054335378.1 → XP_054191353.1  protein PRRC2C isoform X1

  3. XM_054335387.1 → XP_054191362.1  protein PRRC2C isoform X10

  4. XM_054335385.1 → XP_054191360.1  protein PRRC2C isoform X8

  5. XM_054335390.1 → XP_054191365.1  protein PRRC2C isoform X13

  6. XM_054335389.1 → XP_054191364.1  protein PRRC2C isoform X12

  7. XM_054335384.1 → XP_054191359.1  protein PRRC2C isoform X7

  8. XM_054335388.1 → XP_054191363.1  protein PRRC2C isoform X11

  9. XM_054335386.1 → XP_054191361.1  protein PRRC2C isoform X9

    UniProtKB/TrEMBL
    E7EPN9

  10. XM_054335392.1 → XP_054191367.1  protein PRRC2C isoform X15

  11. XM_054335391.1 → XP_054191366.1  protein PRRC2C isoform X14

  12. XM_054335380.1 → XP_054191355.1  protein PRRC2C isoform X3

  13. XM_054335379.1 → XP_054191354.1  protein PRRC2C isoform X2

  14. XM_054335381.1 → XP_054191356.1  protein PRRC2C isoform X4

    UniProtKB/Swiss-Prot
    Q05DM8, Q49A39, Q6PD54, Q9H2N2, Q9HA05, Q9NSM8, Q9NXL3, Q9UF29, Q9UPQ6, Q9Y520

  15. XM_054335382.1 → XP_054191357.1  protein PRRC2C isoform X5

  16. XM_054335393.1 → XP_054191368.1  protein PRRC2C isoform X16

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y520.4 GenPept UniProtKB/Swiss-Prot:Q9Y520

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