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Eva1a eva-1 homolog A, regulator of programmed cell death [ Mus musculus (house mouse) ]

Gene ID: 232146, updated on 21-Apr-2024

Summary

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Official Symbol
Eva1aprovided by MGI
Official Full Name
eva-1 homolog A, regulator of programmed cell deathprovided by MGI
Primary source
MGI:MGI:2385247
See related
Ensembl:ENSMUSG00000035104 AllianceGenome:MGI:2385247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam176a; Tmem166
Summary
Predicted to act upstream of or within apoptotic process and autophagy. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in foot; hand; left lung; renal calyx; and right lung. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 20.7), placenta adult (RPKM 16.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C3; 6 35.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82018058..82070079)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82041048..82093099)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20383 Neighboring gene predicted gene, 32378 Neighboring gene predicted gene, 53287 Neighboring gene predicted gene, 53288 Neighboring gene predicted gene, 40381 Neighboring gene STARR-seq mESC enhancer starr_16424 Neighboring gene predicted gene, 53289

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy. Zhang S, et al. Cell Death Dis, 2017 Feb 2. PMID 28151473, Free PMC Article
  2. Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation. Zhong L, et al. Proteomics, 2017 Mar. PMID 28044434
  3. EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Canham L, et al. Arterioscler Thromb Vasc Biol, 2023 Apr. PMID 36794585, Free PMC Article
  4. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b. Li J, et al. Cardiovasc Res, 2021 Jan 21. PMID 31977009
  5. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Li M, et al. Stem Cell Reports, 2016 Mar 8. PMID 26905199, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy.
    Title: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy.
  2. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b.
    Title: Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b.
  3. Eva1a improves cardiac function.
    Title: Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy.
  4. ATP synthesis, oxidative phosphorylation, and the TCA cycle, are involved in the EVA1A regulatory network.EVA1A plays an important role in neuronal differentiation.
    Title: Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation.
  5. EVA1A deletion results in defective self-renewal and differentiation of NSCs. EVA1A modulates autophagy through the PIK3CA/AKT-mTOR pathway.
    Title: EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • MGC25911, MGC37042

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein eva-1 homolog A
Names
eva-1 homolog A
family with sequence similarity 176, member A
protein FAM176A
transmembrane protein 166

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411592.1 → NP_001398521.1  protein eva-1 homolog A

    Status: VALIDATED

    Source sequence(s)
    AC171502
    UniProtKB/Swiss-Prot
    G3X936, Q91WM6

  2. NM_001411593.1 → NP_001398522.1  protein eva-1 homolog A

    Status: VALIDATED

    Source sequence(s)
    AC171502
    UniProtKB/Swiss-Prot
    G3X936, Q91WM6

  3. NM_001411594.1 → NP_001398523.1  protein eva-1 homolog A

    Status: VALIDATED

    Source sequence(s)
    AC171502
    UniProtKB/Swiss-Prot
    G3X936, Q91WM6
    Related
    ENSMUSP00000117345.2, ENSMUST00000149023.2

  4. NM_001411595.1 → NP_001398524.1  protein eva-1 homolog A

    Status: VALIDATED

    Source sequence(s)
    AC171502
    UniProtKB/Swiss-Prot
    G3X936, Q91WM6

  5. NM_145570.3 → NP_663545.2  protein eva-1 homolog A

    See identical proteins and their annotated locations for NP_663545.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein. Variants 1-5 all encode the protein.
    Source sequence(s)
    AC171502
    Consensus CDS
    CCDS20261.1
    UniProtKB/Swiss-Prot
    G3X936, Q91WM6
    UniProtKB/TrEMBL
    D3Z511
    Related
    ENSMUSP00000037422.9, ENSMUST00000042974.15
    Conserved Domains (1) summary
    pfam14851
    Location:19 → 156
    FAM176; FAM176 family

RNA

  1. NR_177292.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171502
    Related
    ENSMUST00000150691.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    82018058..82070079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WM6.2 GenPept UniProtKB/Swiss-Prot:Q91WM6

Gene LinkOut

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