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Thnsl2 threonine synthase-like 2 (bacterial) [ Mus musculus (house mouse) ]

Gene ID: 232078, updated on 5-Mar-2024

Summary

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Official Symbol
Thnsl2provided by MGI
Official Full Name
threonine synthase-like 2 (bacterial)provided by MGI
Primary source
MGI:MGI:3041254
See related
Ensembl:ENSMUSG00000054474 AllianceGenome:MGI:3041254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TSH2
Summary
Enables pyridoxal phosphate binding activity and serine binding activity. Involved in 2-oxobutyrate biosynthetic process; dephosphorylation; and serine family amino acid catabolic process. Is expressed in renal calyx. Orthologous to human THNSL2 (threonine synthase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 87.1), placenta adult (RPKM 25.3) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C1; 6 32.14 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71105150..71121364, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71128166..71144380, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16251 Neighboring gene predicted gene, 38826 Neighboring gene ribosomal protein L34, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71093854-71094037 Neighboring gene STARR-seq mESC enhancer starr_16253 Neighboring gene predicted gene, 30391 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71104939-71105048 Neighboring gene predicted gene, 38827

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A threonine synthase homolog from a mammalian genome. Donini S, et al. Biochem Biophys Res Commun, 2006 Dec 1. PMID 17034760
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC59076

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables threonine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 2-oxobutyrate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 2-oxobutyrate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serine family amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serine family amino acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
NOT acts_upstream_of_or_within threonine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
threonine synthase-like 2
NP_001029101.1
NP_848500.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033929.2 → NP_001029101.1  threonine synthase-like 2

    See identical proteins and their annotated locations for NP_001029101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI156509, AK165463, BQ042728, CX223060
    Consensus CDS
    CCDS20225.1
    UniProtKB/Swiss-Prot
    Q80W22, Q8R135
    Related
    ENSMUSP00000124423.2, ENSMUST00000160918.8
    Conserved Domains (2) summary
    cd01560
    Location:2 → 463
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK09225
    Location:1 → 453
    PRK09225; threonine synthase; Validated

  2. NM_178413.5 → NP_848500.3  threonine synthase-like 2

    See identical proteins and their annotated locations for NP_848500.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154003, AI156509, AK165463, BQ042728, CX223060
    Consensus CDS
    CCDS20225.1
    UniProtKB/Swiss-Prot
    Q80W22, Q8R135
    Related
    ENSMUSP00000073861.8, ENSMUST00000074241.9
    Conserved Domains (2) summary
    cd01560
    Location:2 → 463
    Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
    PRK09225
    Location:1 → 453
    PRK09225; threonine synthase; Validated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71105150..71121364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80W22.1 GenPept UniProtKB/Swiss-Prot:Q80W22

Gene LinkOut

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