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Uspl1 ubiquitin specific peptidase like 1 [ Mus musculus (house mouse) ]

Gene ID: 231915, updated on 5-Mar-2024

Summary

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Official Symbol
Uspl1provided by MGI
Official Full Name
ubiquitin specific peptidase like 1provided by MGI
Primary source
MGI:MGI:2442342
See related
Ensembl:ENSMUSG00000041264 AllianceGenome:MGI:2442342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430026A01Rik
Summary
Predicted to enable SUMO binding activity and SUMO-specific isopeptidase activity. Acts upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be active in Cajal body. Is expressed in several structures, including early conceptus; metanephros; secondary oocyte; skeletal muscle; and spinal cord. Orthologous to human USPL1 (ubiquitin specific peptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.4), thymus adult (RPKM 11.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G3; 5 89.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (149121338..149152246)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (149184560..149215434)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene macrophage M2 polarization regulator Neighboring gene predicted gene 42788 Neighboring gene glucosamine-6-phosphate deaminase 1 pseudogene Neighboring gene RIKEN cDNA 2310047D07 gene Neighboring gene STARR-seq mESC enhancer starr_14930 Neighboring gene nuclear encoded tRNA asparagine 14 (anticodon GTT) Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:150057677-150057931 Neighboring gene predicted gene, 24105

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neurodevelopmental consequences of Smn depletion in a mouse model of spinal muscular atrophy. Liu H, et al. J Neurosci Res, 2010 Jan. PMID 19642194
  2. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. Bäumer D, et al. PLoS Genet, 2009 Dec. PMID 20019802, Free PMC Article
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • D030048C09

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deSUMOylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Cajal body organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Cajal body organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUMO-specific isopeptidase USPL1
Names
ubiquitin-specific peptidase-like protein 1
NP_001013396.2
NP_001108621.1
NP_001108622.1
NP_001108623.1
NP_001108625.1
NP_001273753.1
NP_001273754.1
NP_001346885.1
NP_001346886.1
XP_036020999.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013378.2 → NP_001013396.2  SUMO-specific isopeptidase USPL1 isoform C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains alternate splice sites in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform C, which is shorter and has a distinct C-terminus, compared to isoform A. Variants 4 and 9 both encode the same isoform (C).
    Source sequence(s)
    AK168702, BC086664, BY203045
    Consensus CDS
    CCDS39406.1
    UniProtKB/Swiss-Prot
    Q3ULM6
    Related
    ENSMUSP00000097978.4, ENSMUST00000100410.10
    Conserved Domains (1) summary
    pfam15499
    Location:216 → 486
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

  2. NM_001115149.1 → NP_001108621.1  SUMO-specific isopeptidase USPL1 isoform A

    See identical proteins and their annotated locations for NP_001108621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (A).
    Source sequence(s)
    AK050969, AK168702, BC086664, BY203045
    Consensus CDS
    CCDS51704.1
    UniProtKB/Swiss-Prot
    Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
    UniProtKB/TrEMBL
    E9QLC6
    Related
    ENSMUSP00000050172.10, ENSMUST00000050472.16
    Conserved Domains (2) summary
    pfam15499
    Location:216 → 486
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:558 → 1087
    DUF4650; Domain of unknown function (DUF4650)

  3. NM_001115150.1 → NP_001108622.1  SUMO-specific isopeptidase USPL1 isoform B

    See identical proteins and their annotated locations for NP_001108622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 7, and 8 all encode the same isoform (B) which is shorter at the N-terminus, compared to isoform A.
    Source sequence(s)
    AK161654, AK168702, AK168981, BC086664, BY203045
    Consensus CDS
    CCDS51706.1
    UniProtKB/Swiss-Prot
    Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
    UniProtKB/TrEMBL
    A0A0R4J1P9
    Related
    ENSMUSP00000113894.2, ENSMUST00000121416.8
    Conserved Domains (2) summary
    pfam15499
    Location:15 → 287
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:359 → 888
    DUF4650; Domain of unknown function (DUF4650)

  4. NM_001115151.1 → NP_001108623.1  SUMO-specific isopeptidase USPL1 isoform D

    See identical proteins and their annotated locations for NP_001108623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, uses alternate splice sites in the 3' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform D, which is shorter and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK146820, AK161654, BC086664, BY203045
    Consensus CDS
    CCDS51705.1
    UniProtKB/Swiss-Prot
    Q3ULM6
    Related
    ENSMUSP00000113176.2, ENSMUST00000117878.8
    Conserved Domains (1) summary
    pfam15499
    Location:17 → 287
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

  5. NM_001115153.1 → NP_001108625.1  SUMO-specific isopeptidase USPL1 isoform A

    See identical proteins and their annotated locations for NP_001108625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A). Variants 1 and 2 both encode the same isoform (A).
    Source sequence(s)
    AK145409, AK161654, AK168981, BC086664, BY203045
    Consensus CDS
    CCDS51704.1
    UniProtKB/Swiss-Prot
    Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
    UniProtKB/TrEMBL
    E9QLC6
    Related
    ENSMUSP00000113247.2, ENSMUST00000122160.8
    Conserved Domains (2) summary
    pfam15499
    Location:216 → 486
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:558 → 1087
    DUF4650; Domain of unknown function (DUF4650)

  6. NM_001286824.1 → NP_001273753.1  SUMO-specific isopeptidase USPL1 isoform E

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform E, which is shorter than isoform A.
    Source sequence(s)
    AK168702, AK168981, BC086664, BY203045
    Consensus CDS
    CCDS71718.1
    UniProtKB/Swiss-Prot
    Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
    UniProtKB/TrEMBL
    D3YW34
    Related
    ENSMUSP00000114104.2, ENSMUST00000119685.8
    Conserved Domains (2) summary
    pfam15499
    Location:202 → 472
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:544 → 1073
    DUF4650; Domain of unknown function (DUF4650)

  7. NM_001286825.1 → NP_001273754.1  SUMO-specific isopeptidase USPL1 isoform B

    See identical proteins and their annotated locations for NP_001273754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 7, and 8 all encode the same isoform (B) which is shorter at the N-terminus, compared to isoform A.
    Source sequence(s)
    AK145409, AK168702, BC086664, BY203045
    Consensus CDS
    CCDS51706.1
    UniProtKB/Swiss-Prot
    Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
    UniProtKB/TrEMBL
    A0A0R4J1P9
    Conserved Domains (2) summary
    pfam15499
    Location:15 → 287
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:359 → 888
    DUF4650; Domain of unknown function (DUF4650)

  8. NM_001359956.1 → NP_001346885.1  SUMO-specific isopeptidase USPL1 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 7, and 8 all encode the same isoform (B) which is shorter at the N-terminus, compared to isoform A.
    Source sequence(s)
    AC122546
    Consensus CDS
    CCDS51706.1
    UniProtKB/Swiss-Prot
    Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
    UniProtKB/TrEMBL
    A0A0R4J1P9
    Conserved Domains (2) summary
    pfam15499
    Location:15 → 287
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:359 → 888
    DUF4650; Domain of unknown function (DUF4650)

  9. NM_001359957.1 → NP_001346886.1  SUMO-specific isopeptidase USPL1 isoform C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains alternate splice sites in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform C, which is shorter and has a distinct C-terminus, compared to isoform A. Variants 4 and 9 both encode the same isoform (C).
    Source sequence(s)
    AC122546
    Consensus CDS
    CCDS39406.1
    Conserved Domains (1) summary
    pfam15499
    Location:216 → 486
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    149121338..149152246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165106.1 → XP_036020999.1  SUMO-specific isopeptidase USPL1 isoform X1

    UniProtKB/Swiss-Prot
    Q0P689, Q3TT12, Q3ULM6, Q3V2W0, Q5RJG8, Q8BHR4
    UniProtKB/TrEMBL
    A0A0R4J1P9
    Conserved Domains (2) summary
    pfam15499
    Location:15 → 287
    Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    pfam15509
    Location:359 → 888
    DUF4650; Domain of unknown function (DUF4650)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ULM6.2 GenPept UniProtKB/Swiss-Prot:Q3ULM6

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