Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uradprovided by MGI
Official Full Name: ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylaseprovided by MGI
Primary source: MGI:MGI:3647519
See related: Ensembl:ENSMUSG00000075543 AllianceGenome:MGI:3647519
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prhoxnb; EG231903
Summary: Enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity. Involved in allantoin metabolic process; purine-containing compound catabolic process; and urate catabolic process. Is active in peroxisome. Orthologous to human URAD (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 64.8) and liver E18 (RPKM 44.2) See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 86.87 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (147251794..147259250, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (147314984..147322440, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identified as the gene encoding the enzyme catalyzing the third step of the pathway from uric acid to S-allantoin.
Title: Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes.

Submit: New GeneRIF Correction

General gene information

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Markers

Prhoxnb (e-PCR), detects polymorphism
- UniSTS:546965

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxy-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in IMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adenosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in allantoin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in amide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dAMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dGMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyadenosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyguanosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyinosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in guanine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hypoxanthine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in urate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xanthine catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Names: OHCU decarboxylase; parahox cluster neighbor; parahox neighbor; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase

NP_001034767.1

EC 4.1.1.97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.