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Bud31 BUD31 homolog [ Mus musculus (house mouse) ]

Gene ID: 231889, updated on 11-Apr-2024

Summary

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Official Symbol
Bud31provided by MGI
Official Full Name
BUD31 homologprovided by MGI
Primary source
MGI:MGI:2141291
See related
Ensembl:ENSMUSG00000038722 AllianceGenome:MGI:2141291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G10; EDG2; EDG-2
Summary
Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of androgen receptor activity. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to colocalize with chromatin. Is expressed in genitourinary system. Orthologous to human BUD31 (BUD31 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 80.7), placenta adult (RPKM 42.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bud31 in Genome Data Viewer
Location:
5 G2; 5 85.05 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145077186..145084888)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145140376..145148078)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:145877013-145877196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:145877310-145877463 Neighboring gene STARR-positive B cell enhancer ABC_E11730 Neighboring gene actin related protein 2/3 complex, subunit 1B Neighboring gene PDGFA associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8091 Neighboring gene pentatricopeptide repeat domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E6397 Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene ATP synthase membrane subunit f

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation. Qin J, et al. Cell Death Differ, 2023 Jan. PMID 36114296, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
    Title: Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of androgen receptor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein BUD31 homolog
Names
maternal G10 transcript
protein G10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008705.2 → NP_001008705.1  protein BUD31 homolog isoform 2

    See identical proteins and their annotated locations for NP_001008705.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA051275, BC057025, BP770669
    Consensus CDS
    CCDS19857.1
    UniProtKB/Swiss-Prot
    Q6PGH1
    Related
    ENSMUSP00000125590.2, ENSMUST00000162308.8
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 102
    G10; G10 protein

  2. NM_001310770.1 → NP_001297699.1  protein BUD31 homolog isoform 1

    See identical proteins and their annotated locations for NP_001297699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC127411, BP770669, BX520786, CX567360
    Consensus CDS
    CCDS80463.1
    UniProtKB/Swiss-Prot
    E0CX20, Q6PGH1
    Related
    ENSMUSP00000125564.2, ENSMUST00000160075.2
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

  3. NM_001310771.1 → NP_001297700.1  protein BUD31 homolog isoform 1

    See identical proteins and their annotated locations for NP_001297700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA051275, BP770669, CJ044770, CJ047068, CX567360
    Consensus CDS
    CCDS80463.1
    UniProtKB/Swiss-Prot
    E0CX20, Q6PGH1
    Related
    ENSMUSP00000125738.2, ENSMUST00000162594.8
    Conserved Domains (1) summary
    pfam01125
    Location:1 → 143
    G10; G10 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145077186..145084888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGH1.2 GenPept UniProtKB/Swiss-Prot:Q6PGH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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