U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp12 zinc finger protein 12 [ Mus musculus (house mouse) ]

Gene ID: 231866, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp12provided by MGI
Official Full Name
zinc finger protein 12provided by MGI
Primary source
MGI:MGI:99157
See related
Ensembl:ENSMUSG00000029587 AllianceGenome:MGI:99157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf12; Krox-7; Zfp-12; C530015C18
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF12 (zinc finger protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.7), CNS E14 (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 G2; 5 82.02 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143220910..143233712)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143235138..143248834)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family, member E4A Neighboring gene RIKEN cDNA 4930448H16 gene Neighboring gene predicted gene, 38735 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143996641-143996853 Neighboring gene zinc finger protein 316 Neighboring gene cDNA sequence BC030343 Neighboring gene zinc finger protein 853

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
  2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289589.2 → NP_001276518.1  zinc finger protein 12 isoform 1

    See identical proteins and their annotated locations for NP_001276518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC123686
    Consensus CDS
    CCDS71702.1
    UniProtKB/Swiss-Prot
    Q7TSI0, Q8C7Q7
    Related
    ENSMUSP00000032591.9, ENSMUST00000032591.15
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:251 → 677
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:321 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001289590.2 → NP_001276519.1  zinc finger protein 12 isoform 3

    See identical proteins and their annotated locations for NP_001276519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' region and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC123686
    UniProtKB/TrEMBL
    Q6PB81
    Conserved Domains (2) summary
    COG5048
    Location:167 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001424656.1 → NP_001411585.1  zinc finger protein 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123686
    UniProtKB/Swiss-Prot
    Q7TSI0, Q8C7Q7

  4. NM_001424657.1 → NP_001411586.1  zinc finger protein 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123686
    UniProtKB/TrEMBL
    Q6PB81

  5. NM_001424658.1 → NP_001411587.1  zinc finger protein 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123686
    UniProtKB/TrEMBL
    Q6PB81

  6. NM_177681.5 → NP_808349.1  zinc finger protein 12 isoform 2

    See identical proteins and their annotated locations for NP_808349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC123686
    Consensus CDS
    CCDS19837.1
    UniProtKB/Swiss-Prot
    Q7TSI0
    Related
    ENSMUSP00000076693.5, ENSMUST00000077485.11
    Conserved Domains (7) summary
    smart00349
    Location:8 → 65
    KRAB; krueppel associated box
    COG5048
    Location:219 → 645
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289 → 309
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:371 → 393
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:386 → 410
    zf-H2C2_2; Zinc-finger double domain
    cl11841
    Location:7 → 129
    PSII_Pbs27; Photosystem II Pbs27

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143220910..143233712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165104.1 → XP_036020997.1  zinc finger protein 12 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:18 → 452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:96 → 116
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_017320875.3 → XP_017176364.1  zinc finger protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSI0, Q8C7Q7
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:251 → 677
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:321 → 341
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_011240980.4 → XP_011239282.1  zinc finger protein 12 isoform X3

    See identical proteins and their annotated locations for XP_011239282.1

    Conserved Domains (2) summary
    COG5048
    Location:18 → 452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:96 → 116
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSI0.1 GenPept UniProtKB/Swiss-Prot:Q7TSI0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous