Fbxl18 F-box and leucine-rich repeat protein 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxl18provided by MGI
Official Full Name: F-box and leucine-rich repeat protein 18provided by MGI
Primary source: MGI:MGI:2444450
See related: Ensembl:ENSMUSG00000066640 AllianceGenome:MGI:2444450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130019G13Rik; C330021B20Rik
Summary: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL18 (F-box and leucine rich repeat protein 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 23.9), adrenal adult (RPKM 20.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.79 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142852701..142882696, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142871789..142896721, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC.
Title: Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC.
Study showed that LRRK2 phosphorylation is required for LRRK2 to bind to Fbxl18, and that this interaction is important for regulating the amount of LRRK2 via ubiquitination of LRRK2 by the SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation of LRRK2. We also show that LRRK2 can induce caspase 8 mediated cell death and that the degradation of LRRK2 mediated by Fbxl18 can prevent LRRK2-mediated toxicity.
Title: Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

AI427077 (e-PCR)
- UniSTS:165439

NoName (e-PCR)
- UniSTS:237131

UniSTS:488446 (e-PCR)
- UniSTS:488446

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033312.3 → NP_001028484.2 F-box/LRR-repeat protein 18

See identical proteins and their annotated locations for NP_001028484.2

Status: VALIDATED

Source sequence(s)

AK049302, AK144757

Consensus CDS

CCDS19831.1

UniProtKB/TrEMBL

F8VQK6, Q3U4A0

Related

ENSMUSP00000041700.8, ENSMUST00000035985.8

Conserved Domains (2) summary

sd00034
Location:522 → 548

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:22 → 64

F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

142852701..142882696 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165103.1 → XP_036020996.1 F-box/LRR-repeat protein 18 isoform X1

UniProtKB/TrEMBL

Q3U4A0

Conserved Domains (1) summary

sd00034
Location:433 → 459

LRR_AMN1; leucine-rich repeat [structural motif]