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Adap1 ArfGAP with dual PH domains 1 [ Mus musculus (house mouse) ]

Gene ID: 231821, updated on 21-Apr-2024

Summary

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Official Symbol
Adap1provided by MGI
Official Full Name
ArfGAP with dual PH domains 1provided by MGI
Primary source
MGI:MGI:2442201
See related
Ensembl:ENSMUSG00000056413 AllianceGenome:MGI:2442201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GC1L; Centa1; p42IP4; 4930431P11Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Predicted to be located in cytosol and nucleus. Predicted to be active in intracellular membrane-bounded organelle and plasma membrane. Is expressed in nervous system. Orthologous to human ADAP1 (ArfGAP with dual PH domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 78.3), large intestine adult (RPKM 65.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 78.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139257631..139311516, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139271876..139325763, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene golgi to ER traffic protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E4802 Neighboring gene STARR-positive B cell enhancer ABC_E2770 Neighboring gene STARR-positive B cell enhancer ABC_E6389 Neighboring gene STARR-positive B cell enhancer ABC_E9266 Neighboring gene STARR-positive B cell enhancer ABC_E8825 Neighboring gene STARR-positive B cell enhancer ABC_E6390 Neighboring gene cytochrome c oxidase assembly protein 19 Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus. Szatmari EM, et al. eNeuro, 2021 Jan-Feb. PMID 33139322, Free PMC Article
  2. ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival. Van Duzer A, et al. Life Sci Alliance, 2019 Dec. PMID 31792062, Free PMC Article
  3. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
  4. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
  5. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAP1/Centaurin-alpha1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus.
    Title: ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol 1,3,4,5 tetrakisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arf-GAP with dual PH domain-containing protein 1
Names
centaurin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172723.4 → NP_766311.2  arf-GAP with dual PH domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    BC079634, BY740716, CX242691
    Consensus CDS
    CCDS19806.2
    UniProtKB/TrEMBL
    E9PY16, Q6PGM4
    Related
    ENSMUSP00000106489.2, ENSMUST00000110865.2
    Conserved Domains (3) summary
    smart00105
    Location:10 → 126
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd01251
    Location:252 → 357
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:130 → 238
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139257631..139311516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504669.4 → XP_006504732.1  arf-GAP with dual PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006504732.1

    UniProtKB/TrEMBL
    Q6PGM4, Q8BVR8
    Conserved Domains (3) summary
    cd01251
    Location:180 → 285
    PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
    cd13252
    Location:58 → 166
    PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
    cl28907
    Location:1 → 41
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
Nucleotide Protein Strain
Heading Accession and Version

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