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Agfg2 ArfGAP with FG repeats 2 [ Mus musculus (house mouse) ]

Gene ID: 231801, updated on 5-Mar-2024

Summary

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Official Symbol
Agfg2provided by MGI
Official Full Name
ArfGAP with FG repeats 2provided by MGI
Primary source
MGI:MGI:2443267
See related
Ensembl:ENSMUSG00000029722 AllianceGenome:MGI:2443267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hrbl; RABR; RAB-R; A630095P14Rik
Summary
This gene encodes a paralog of the HIV-1 Rev binding proteins that serve as cellular co-factors for HIV-1 Rev protein in shuttling viral pre-mRNAs from the nucleus to the cytoplasm. The encoded protein contains an ADP-ribosylation factor GTPase activating protein (Arf-GAP) zinc finger domain, several phenylalanine-glycine (FG) motifs and asparagine-proline-phenylalanine (NPF) motifs. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in thymus adult (RPKM 56.4), adrenal adult (RPKM 28.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.59 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137648725..137683068, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137650463..137684806, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20605 Neighboring gene sin3 associated polypeptide Neighboring gene insulin receptor substrate 3 Neighboring gene STARR-positive B cell enhancer ABC_E236 Neighboring gene predicted gene 15498 Neighboring gene predicted gene, 54308 Neighboring gene Sp110 nuclear body protein, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Organization patterns of the AGFG genes: an evolutionary study. Panaro MA, et al. Immunopharmacol Immunotoxicol, 2011 Mar. PMID 21284487
  2. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. Coda L, et al. J Biol Chem, 1998 Jan 30. PMID 9446614
  3. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. Wong KA, et al. PLoS One, 2012. PMID 22558309, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7148, MGC61203

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arf-GAP domain and FG repeat-containing protein 2
Names
HIV-1 Rev-binding protein-like protein
arf-GAP domain and FG repeats-containing protein 2
rev/Rex activation domain-binding protein related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303266.1 → NP_001290195.1  arf-GAP domain and FG repeat-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001290195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional in-frame exon in the 3' coding region, compared to variant 2. The resulting protein (isoform 3) is longer than isoform 2.
    Source sequence(s)
    AC124730
    Consensus CDS
    CCDS80443.1
    UniProtKB/TrEMBL
    Q3TBU7, Q3U2K8
    Related
    ENSMUSP00000098112.5, ENSMUST00000100544.11
    Conserved Domains (1) summary
    cl02464
    Location:40 → 152
    ArfGap; Putative GTPase activating protein for Arf

  2. NM_001303271.1 → NP_001290200.1  arf-GAP domain and FG repeat-containing protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and contains an additional in-frame exon in the 3' coding region, compared to variant 2. The resulting protein (isoform 4) is longer than isoform 2.
    Source sequence(s)
    AC124730
    UniProtKB/TrEMBL
    Q3TBU7
    Related
    ENSMUSP00000117351.2, ENSMUST00000151839.2
    Conserved Domains (1) summary
    cl02464
    Location:40 → 152
    ArfGap; Putative GTPase activating protein for Arf

  3. NM_178162.3 → NP_835456.1  arf-GAP domain and FG repeat-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_835456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the shortest isoform (2).
    Source sequence(s)
    AC124730, BC046788
    Consensus CDS
    CCDS19774.1
    UniProtKB/Swiss-Prot
    Q80WC7, Q8BKS5, Q99J67
    UniProtKB/TrEMBL
    Q3TBU7
    Related
    ENSMUSP00000031736.10, ENSMUST00000031736.16
    Conserved Domains (1) summary
    cl02464
    Location:40 → 152
    ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137648725..137683068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504570.3 → XP_006504633.1  arf-GAP domain and FG repeat-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q3TBU7
    Conserved Domains (2) summary
    PHA03247
    Location:163 → 411
    PHA03247; large tegument protein UL36; Provisional
    cd17903
    Location:30 → 146
    ArfGap_AGFG2; ArfGAP domain of AGFG2 (ArfGAP domain and FG repeat-containing protein 2)

  2. XM_006504569.3 → XP_006504632.1  arf-GAP domain and FG repeat-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3TBU7
    Conserved Domains (2) summary
    PHA03247
    Location:146 → 453
    PHA03247; large tegument protein UL36; Provisional
    cd17903
    Location:30 → 146
    ArfGap_AGFG2; ArfGAP domain of AGFG2 (ArfGAP domain and FG repeat-containing protein 2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145566.1: Suppressed sequence

    Description
    NM_145566.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WC7.1 GenPept UniProtKB/Swiss-Prot:Q80WC7

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