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METAP1 methionyl aminopeptidase 1 [ Homo sapiens (human) ]

Gene ID: 23173, updated on 3-Apr-2024

Summary

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Official Symbol
METAP1provided by HGNC
Official Full Name
methionyl aminopeptidase 1provided by HGNC
Primary source
HGNC:HGNC:15789
See related
Ensembl:ENSG00000164024 MIM:610151; AllianceGenome:HGNC:15789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP1A; MetAP1A
Summary
Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Involved in platelet aggregation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 20.9), testis (RPKM 19.8) and 25 other tissues See more
Orthologs
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Genomic context

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See METAP1 in Genome Data Viewer
Location:
4q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (98995721..99062809)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (102310655..102377714)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99916872..99983960)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 149 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21736 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15580 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:99917285-99918067 Neighboring gene uncharacterized LOC124900738 Neighboring gene microRNA 3684 Neighboring gene activator of basal transcription 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21737 Neighboring gene ADH5 promoter Neighboring gene uncharacterized LOC100507053 Neighboring gene Sharpr-MPRA regulatory region 12553 Neighboring gene uncharacterized LOC124900739 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. METAP1 mutation is a novel candidate for autosomal recessive intellectual disability. Caglayan AO, et al. J Hum Genet, 2021 Feb. PMID 32764695, Free PMC Article
  2. Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases. Kishor C, et al. J Med Chem, 2013 Jul 11. PMID 23767698
  3. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Hu X, et al. Proc Natl Acad Sci U S A, 2006 Nov 28. PMID 17114291, Free PMC Article
  4. MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state. Frottin F, et al. Oncotarget, 2016 Sep 27. PMID 27542228, Free PMC Article
  5. Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. Xiao Q, et al. Biochemistry, 2010 Jul 6. PMID 20521764, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METAP1 mutation is a novel candidate for autosomal recessive intellectual disability.
    Title: METAP1 mutation is a novel candidate for autosomal recessive intellectual disability.
  2. MetAP1 and MetAP2 have roles in driving cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state
    Title: MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.
  3. Data indicate that pyridinylpyrimidine-based molecules displayed species specificity behavior against methionine aminopeptidases (MetAPs).
    Title: Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases.
  4. the substrate specificities of Escherichia coli MetAP1, human MetAP1, and human MetAP2 were systematically profiled
    Title: Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
  7. Human MetAP1 is distinct from other members of the MetAP superfamily in the number of metal ions employed and likely mechanism of catalysis.
    Title: Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases.
  8. A comparison of the structual differences between Type I and Type II methionine aminopeptidases.
    Title: Structural basis for the functional differences between type I and type II human methionine aminopeptidases.
  9. Data show that human methionine aminopeptidase 1 (MetAP1) fully rescued the slow growth phenotype associated with deletion of yeast MetAP1, suggesting that the yeast and human proteins may have similar roles in vivo.
    Title: Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae.
  10. results suggest that MetAP1 plays an important role in G(2)/M phase of the cell cycle and that it may serve as a promising target for the discovery and development of new anticancer agents
    Title: Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0094, DKFZp781C0419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloexopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid modification TAS
Traceable Author Statement
more info
 PubMed 
involved_in peptidyl-methionine modification TAS
Traceable Author Statement
more info
 PubMed 
involved_in platelet aggregation HMP PubMed 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
methionine aminopeptidase 1
Names
MAP 1
metAP 1
peptidase M 1
NP_055958.2
XP_011530079.1
XP_011530080.1
XP_011530081.1
XP_016863403.1
XP_016863405.1
XP_016863406.1
XP_024309714.1
XP_024309715.1
XP_024309719.1
XP_047305839.1
XP_047305840.1
XP_047305841.1
XP_047305842.1
XP_047305843.1
XP_054205353.1
XP_054205354.1
XP_054205355.1
XP_054205356.1
XP_054205357.1
XP_054205358.1
XP_054205359.1
XP_054205360.1
XP_054205361.1
XP_054205362.1
XP_054205363.1
XP_054205364.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015143.3 → NP_055958.2  methionine aminopeptidase 1

    See identical proteins and their annotated locations for NP_055958.2

    Status: VALIDATED

    Source sequence(s)
    BC030054, D42084, DA178462
    Consensus CDS
    CCDS47110.1
    UniProtKB/Swiss-Prot
    B4E2E6, P53582
    UniProtKB/TrEMBL
    Q5CZ91
    Related
    ENSP00000296411.6, ENST00000296411.11
    Conserved Domains (3) summary
    PLN03158
    Location:14 → 382
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:136 → 373
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:12 → 53
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    98995721..99062809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007914.3 → XP_016863403.1  methionine aminopeptidase 1 isoform X4

    UniProtKB/TrEMBL
    Q5CZ91

  2. XM_011531779.3 → XP_011530081.1  methionine aminopeptidase 1 isoform X3

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (3) summary
    PLN03158
    Location:14 → 338
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:136 → 329
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:12 → 53
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding

  3. XM_011531777.4 → XP_011530079.1  methionine aminopeptidase 1 isoform X1

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (3) summary
    PLN03158
    Location:3 → 369
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:123 → 360
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    cl20224
    Location:24 → 40
    zf-MYND; MYND finger

  4. XM_024453946.2 → XP_024309714.1  methionine aminopeptidase 1 isoform X6

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (1) summary
    cl00279
    Location:3 → 325
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

  5. XM_047449884.1 → XP_047305840.1  methionine aminopeptidase 1 isoform X5

  6. XM_047449883.1 → XP_047305839.1  methionine aminopeptidase 1 isoform X5

  7. XM_017007916.3 → XP_016863405.1  methionine aminopeptidase 1 isoform X8

    UniProtKB/TrEMBL
    Q5CZ91

  8. XM_017007917.3 → XP_016863406.1  methionine aminopeptidase 1 isoform X8

    UniProtKB/TrEMBL
    Q5CZ91

  9. XM_047449885.1 → XP_047305841.1  methionine aminopeptidase 1 isoform X5

  10. XM_011531778.3 → XP_011530080.1  methionine aminopeptidase 1 isoform X2

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (3) summary
    PRK12318
    Location:41 → 337
    PRK12318; methionine aminopeptidase; Provisional
    cd01086
    Location:101 → 338
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    cl20224
    Location:3 → 18
    zf-MYND; MYND finger

  11. XM_024453947.2 → XP_024309715.1  methionine aminopeptidase 1 isoform X7

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (1) summary
    cl00279
    Location:2 → 303
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

  12. XM_047449886.1 → XP_047305842.1  methionine aminopeptidase 1 isoform X9

  13. XM_047449887.1 → XP_047305843.1  methionine aminopeptidase 1 isoform X9

  14. XM_024453951.2 → XP_024309719.1  methionine aminopeptidase 1 isoform X9

    UniProtKB/TrEMBL
    Q5CZ91
    Conserved Domains (1) summary
    cl00279
    Location:3 → 268
    APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    102310655..102377714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349381.1 → XP_054205356.1  methionine aminopeptidase 1 isoform X4

  2. XM_054349380.1 → XP_054205355.1  methionine aminopeptidase 1 isoform X3

  3. XM_054349378.1 → XP_054205353.1  methionine aminopeptidase 1 isoform X1

  4. XM_054349383.1 → XP_054205358.1  methionine aminopeptidase 1 isoform X6

  5. XM_054349385.1 → XP_054205360.1  methionine aminopeptidase 1 isoform X8

  6. XM_054349386.1 → XP_054205361.1  methionine aminopeptidase 1 isoform X8

  7. XM_054349384.1 → XP_054205359.1  methionine aminopeptidase 1 isoform X7

  8. XM_054349379.1 → XP_054205354.1  methionine aminopeptidase 1 isoform X2

  9. XM_054349382.1 → XP_054205357.1  methionine aminopeptidase 1 isoform X5

  10. XM_054349387.1 → XP_054205362.1  methionine aminopeptidase 1 isoform X9

  11. XM_054349388.1 → XP_054205363.1  methionine aminopeptidase 1 isoform X9

  12. XM_054349389.1 → XP_054205364.1  methionine aminopeptidase 1 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53582.2 GenPept UniProtKB/Swiss-Prot:P53582

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