Gcn1 GCN1 activator of EIF2AK4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gcn1provided by MGI
Official Full Name: GCN1 activator of EIF2AK4provided by MGI
Primary source: MGI:MGI:2444248
See related: Ensembl:ENSMUSG00000041638 AllianceGenome:MGI:2444248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GCN1L; Gcn1l1; mKIAA0219; 4932409G22; G431004K08Rik
Summary: Predicted to enable protein kinase binding activity; protein kinase regulator activity; and ribosome binding activity. Involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Part of polysome. Is expressed in several structures, including gut; heart; hemolymphoid system gland; liver; and lung. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 25.3), thymus adult (RPKM 23.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115703177..115760713)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115565117..115622654)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of GCN1 causes severe growth retardation and embryonic lethality. GCN1 regulates the eIF2alpha-mediated stress response, cell cycle and cell proliferation.
Title: Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235280

NoName (e-PCR)
- UniSTS:235281

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

RH125341 (e-PCR)
- UniSTS:162163

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables stalled ribosome sensor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GCN2-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stalled ribosome sensor GCN1

Names: GCN1 eIF-2-alpha kinase activator homolog; GCN1 general control of amino-acid synthesis 1-like 1; GCN1-like protein 1; eIF-2-alpha kinase activator GCN1; general control of amino-acid synthesis 1-like protein 1; translational activator GCN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172719.2 → NP_766307.2 stalled ribosome sensor GCN1

Status: VALIDATED

Source sequence(s)

AK077013, AK089324, AK147257, BY582410, CD350892, CJ104712

Consensus CDS

CCDS19595.1

UniProtKB/Swiss-Prot

B2RWW6, E9PVA8

UniProtKB/TrEMBL

Q3UHQ5

Related

ENSMUSP00000069432.8, ENSMUST00000064454.12

Conserved Domains (4) summary

cd00020
Location:1498 → 1601

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam12074
Location:355 → 705

DUF3554; Domain of unknown function (DUF3554)

pfam13646
Location:1616 → 1721

HEAT_2; HEAT repeats

sd00044
Location:1461 → 1485

HEAT; HEAT repeat [structural motif]