Oasl1 2'-5' oligoadenylate synthetase-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oasl1provided by MGI
Official Full Name: 2'-5' oligoadenylate synthetase-like 1provided by MGI
Primary source: MGI:MGI:2180849
See related: Ensembl:ENSMUSG00000041827 AllianceGenome:MGI:2180849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: oasl9; 7530414C13Rik
Summary: Enables double-stranded RNA binding activity. Acts upstream of or within interleukin-27-mediated signaling pathway. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in testis. Orthologous to human OASL (2'-5'-oligoadenylate synthetase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 38.2), stomach adult (RPKM 33.5) and 9 other tissues See more
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Genomic context

Location:: 5 F; 5 55.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115061236..115075970)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114923143..114937911)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway.
Title: OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway.
results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections.
Title: OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses.
these results show that OASL1 deficiency promotes the antitumor immune response, and thus, OASL1 could be a good therapeutic target for treating tumors.
Title: 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons.
OASL1 deficiency promotes antiviral immunity against local mucosal viral infection.
Title: OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production.
Data from knockout mice suggest that Oasl1 is involved in regulation of innate immunity; Oasl1 knockout mice mount a better virus-specific CD8-positive T-cell response to lymphocytic choriomeningitis virus.
Title: Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.
OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.
Title: OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase-like protein 1

Names: 2',5'-oligoadenylate synthetase-like 9; 2,5-oligoadenylate synthetase-like 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359945.1 → NP_001346874.1 2'-5'-oligoadenylate synthase-like protein 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC117799, AK150863

Consensus CDS

CCDS19575.1

UniProtKB/Swiss-Prot

Q3UBP8, Q8K2A2, Q8QZV5, Q8VI94

Related

ENSMUSP00000107771.4, ENSMUST00000112143.4

Conserved Domains (4) summary

cd05400
Location:29 → 208

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam00240
Location:432 → 498

ubiquitin; Ubiquitin family

pfam10421
Location:165 → 347

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

cl00155
Location:350 → 429

UBQ; Ubiquitin-like proteins
NM_001359946.1 → NP_001346875.1 2'-5'-oligoadenylate synthase-like protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC117799

Conserved Domains (3) summary

pfam00240
Location:253 → 319

ubiquitin; Ubiquitin family

pfam10421
Location:9 → 168

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

cl00155
Location:171 → 250

UBQ; Ubiquitin-like proteins
NM_145209.3 → NP_660210.1 2'-5'-oligoadenylate synthase-like protein 1 isoform a

See identical proteins and their annotated locations for NP_660210.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AK078690

Consensus CDS

CCDS19575.1

UniProtKB/Swiss-Prot

Q3UBP8, Q8K2A2, Q8QZV5, Q8VI94

Related

ENSMUSP00000031540.5, ENSMUST00000031540.11

Conserved Domains (4) summary

cd05400
Location:29 → 208

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam00240
Location:432 → 498

ubiquitin; Ubiquitin family

pfam10421
Location:165 → 347

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

cl00155
Location:350 → 429

UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

115061236..115075970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530295.5 → XP_006530358.1 2'-5'-oligoadenylate synthase-like protein 1 isoform X1

Conserved Domains (2) summary

cd05400
Location:29 → 208

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:165 → 215

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus