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Myo1h myosin 1H [ Mus musculus (house mouse) ]

Gene ID: 231646, updated on 5-Mar-2024

Summary

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Official Symbol
Myo1hprovided by MGI
Official Full Name
myosin 1Hprovided by MGI
Primary source
MGI:MGI:1914674
See related
Ensembl:ENSMUSG00000066952 AllianceGenome:MGI:1914674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4631401O15Rik
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in several structures, including alimentary system; gonad; nervous system; neural retina; and respiratory system. Orthologous to human MYO1H (myosin IH). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 21.5), stomach adult (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.99 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114427314..114502637)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114289253..114364576)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetyl-Coenzyme A carboxylase beta Neighboring gene STARR-seq mESC enhancer starr_14069 Neighboring gene STARR-seq mESC enhancer starr_14070 Neighboring gene forkhead box N4 Neighboring gene VISTA enhancer mm1522 Neighboring gene STARR-positive B cell enhancer mm9_chr5:114762243-114762544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114765155-114765411 Neighboring gene potassium channel tetramerisation domain containing 10 Neighboring gene ubiquitin protein ligase E3B Neighboring gene microRNA 7027 Neighboring gene STARR-positive B cell enhancer ABC_E278 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, et al. J Assoc Res Otolaryngol, 2002 Dec. PMID 12486594, Free PMC Article
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
unconventional myosin-Ih
Names
myosin-Ih

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164573.2 → NP_001158045.1  unconventional myosin-Ih isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122282, AC127255
    Consensus CDS
    CCDS51622.1
    UniProtKB/TrEMBL
    A0A0J9YUC4, E9PWM9
    Related
    ENSMUSP00000144110.2, ENSMUST00000202006.4
    Conserved Domains (3) summary
    smart00242
    Location:8 → 689
    MYSc; Myosin. Large ATPases
    cd01378
    Location:26 → 678
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:834 → 1001
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  2. NM_001368675.1 → NP_001355604.1  unconventional myosin-Ih isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127255
    Consensus CDS
    CCDS89974.1
    UniProtKB/TrEMBL
    B7ZMY1, B7ZMY2
    Related
    ENSMUSP00000144682.2, ENSMUST00000196676.5
    Conserved Domains (1) summary
    pfam06017
    Location:25 → 206
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  3. NM_001368676.1 → NP_001355605.1  unconventional myosin-Ih isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127255
    Consensus CDS
    CCDS89974.1
    UniProtKB/TrEMBL
    B7ZMY1, B7ZMY2
    Related
    ENSMUSP00000144492.2, ENSMUST00000199567.5
    Conserved Domains (1) summary
    pfam06017
    Location:25 → 206
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114427314..114502637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165090.1 → XP_036020983.1  unconventional myosin-Ih isoform X1

    UniProtKB/TrEMBL
    B7ZMY1, B7ZMY2
    Conserved Domains (1) summary
    pfam06017
    Location:25 → 206
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_146163.2: Suppressed sequence

    Description
    NM_146163.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6A1.2 GenPept UniProtKB/Swiss-Prot:Q9D6A1

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