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MAST2 microtubule associated serine/threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 23139, updated on 5-Mar-2024

Summary

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Official Symbol
MAST2provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase 2provided by HGNC
Primary source
HGNC:HGNC:19035
See related
Ensembl:ENSG00000086015 MIM:612257; AllianceGenome:HGNC:19035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTSSK; MAST205
Summary
Enables phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 25.4), heart (RPKM 11.8) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See MAST2 in Genome Data Viewer
Location:
1p34.1
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45803612..46036122)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45680810..45913311)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46269284..46501794)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 835 Neighboring gene ribosomal protein L6 pseudogene 1 Neighboring gene MPRA-validated peak201 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46304499-46305000 Neighboring gene Sharpr-MPRA regulatory region 10352 Neighboring gene uncharacterized LOC105378694 Neighboring gene translation machinery associated 16 homolog pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 5403 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46392868-46393561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46406659-46407160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46407161-46407660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 836 Neighboring gene MPRA-validated peak202 silencer Neighboring gene P3R3URF-PIK3R3 readthrough Neighboring gene OCT4 hESC enhancer GRCh37_chr1:46502635-46503136 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46508718-46509562 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46509563-46510406 Neighboring gene uncharacterized LOC124904171 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:46527714-46528913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 990 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene COX7B pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia. Rodríguez-García ME, et al. Am J Med Genet A, 2020 Jun. PMID 32198973
  2. High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer. Jiao Y, et al. Sci Rep, 2019 Dec 27. PMID 31882722, Free PMC Article
  3. A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans. Huang N, et al. Biol Reprod, 2015 Sep. PMID 26203179, Free PMC Article
  4. Deciphering the unconventional peptide binding to the PDZ domain of MAST2. Delhommel F, et al. Biochem J, 2015 Jul 1. PMID 25942057
  5. Transcriptional regulation of human-specific SVAF₁ retrotransposons by cis-regulatory MAST2 sequences. Zabolotneva AA, et al. Gene, 2012 Aug 15. PMID 22609064

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
    Title: A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
  2. MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia.
    Title: MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia.
  3. High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
    Title: High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
  4. we observed 3 case-specific duplications of the autosomal gene MAST2, and in a replication phase we found another 11 duplications
    Title: A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.
  5. Viral and PTEN peptide interactions to MAST2-PDZ occur via a unique kinetic step which involves both canonical C-terminal PBM binding and N-terminal anchoring.
    Title: Deciphering the unconventional peptide binding to the PDZ domain of MAST2.
  6. MAST2 gene rearrangements occur in invasive breast carcinoma.
    Title: MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
  7. MAST205 plays an important role in regulating CFTR expression and function
    Title: MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport.
  8. The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells.
    Title: Transcriptional regulation of human-specific SVAF₁ retrotransposons by cis-regulatory MAST2 sequences.
  9. Overexpression of MAST1 or MAST2 gene fusions has a proliferative effect both in vitro and in vivo in breast cancer cell lines.
    Title: Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
  10. Recruitment of a MAST2 CpG island was most likely beneficial to the hybrid retrotransposons because it could significantly increase retrotransposition frequency.
    Title: Novel family of human transposable elements formed due to fusion of the first exon of gene MAST2 with retrotransposon SVA.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39200, KIAA0807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatid differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule-associated serine/threonine-protein kinase 2
Names
microtubule associated testis specific serine/threonine protein kinase
NP_001306174.1
NP_001311249.1
NP_001311250.1
NP_055927.2
XP_005270712.1
XP_005270713.1
XP_006710540.1
XP_011539361.1
XP_011539363.1
XP_011539364.1
XP_011539365.1
XP_011539366.1
XP_011539369.1
XP_011539370.1
XP_011539371.1
XP_016856241.1
XP_016856242.1
XP_016856244.1
XP_047306052.1
XP_047306061.1
XP_047306067.1
XP_047306072.1
XP_047306077.1
XP_047306078.1
XP_047306079.1
XP_047306085.1
XP_047306086.1
XP_047306094.1
XP_047306097.1
XP_047306098.1
XP_047306101.1
XP_047306105.1
XP_047306106.1
XP_047306109.1
XP_054191305.1
XP_054191306.1
XP_054191307.1
XP_054191308.1
XP_054191309.1
XP_054191310.1
XP_054191311.1
XP_054191312.1
XP_054191313.1
XP_054191314.1
XP_054191315.1
XP_054191316.1
XP_054191317.1
XP_054191318.1
XP_054191319.1
XP_054191320.1
XP_054191321.1
XP_054191322.1
XP_054191323.1
XP_054191324.1
XP_054191325.1
XP_054191326.1
XP_054191327.1
XP_054191328.1
XP_054191329.1
XP_054191330.1
XP_054191331.1
XP_054191332.1
XP_054191333.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319245.2 → NP_001306174.1  microtubule-associated serine/threonine-protein kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB047005, AL358075, AL603882, BC065499
    UniProtKB/Swiss-Prot
    Q6P0Q8
    Conserved Domains (4) summary
    smart00220
    Location:512 → 785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1105 → 1186
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:511 → 790
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:201 → 475
    DUF1908; Domain of unknown function (DUF1908)

  2. NM_001324320.2 → NP_001311249.1  microtubule-associated serine/threonine-protein kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL358075, AL603882, AL603888, AL645480
    Conserved Domains (4) summary
    smart00220
    Location:519 → 792
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1112 → 1193
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:518 → 797
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:201 → 482
    DUF1908; Domain of unknown function (DUF1908)

  3. NM_001324321.2 → NP_001311250.1  microtubule-associated serine/threonine-protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL358075, AL603888, AL645480
    Conserved Domains (4) summary
    smart00220
    Location:358 → 631
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:951 → 1032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:357 → 636
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:40 → 321
    DUF1908; Domain of unknown function (DUF1908)

  4. NM_015112.3 → NP_055927.2  microtubule-associated serine/threonine-protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_055927.2

    Status: VALIDATED

    Source sequence(s)
    AB047005, AL540100, AL603882, BC065499, CN297081
    Consensus CDS
    CCDS41326.1
    UniProtKB/Swiss-Prot
    O94899, Q5VT07, Q5VT08, Q6P0Q8, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8
    Related
    ENSP00000354671.2, ENST00000361297.7
    Conserved Domains (4) summary
    smart00220
    Location:512 → 785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1105 → 1186
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:511 → 790
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:201 → 475
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    45803612..46036122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541059.3 → XP_011539361.1  microtubule-associated serine/threonine-protein kinase 2 isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:584 → 857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1177 → 1258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583 → 862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266 → 547
    DUF1908; Domain of unknown function (DUF1908)

  2. XM_011541069.3 → XP_011539371.1  microtubule-associated serine/threonine-protein kinase 2 isoform X24

    Conserved Domains (4) summary
    smart00220
    Location:584 → 857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1177 → 1258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583 → 862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266 → 547
    DUF1908; Domain of unknown function (DUF1908)

  3. XM_011541061.3 → XP_011539363.1  microtubule-associated serine/threonine-protein kinase 2 isoform X2

    Conserved Domains (4) summary
    smart00220
    Location:584 → 857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1177 → 1258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583 → 862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266 → 547
    DUF1908; Domain of unknown function (DUF1908)

  4. XM_047450141.1 → XP_047306097.1  microtubule-associated serine/threonine-protein kinase 2 isoform X25

  5. XM_011541062.3 → XP_011539364.1  microtubule-associated serine/threonine-protein kinase 2 isoform X3

    Conserved Domains (4) summary
    smart00220
    Location:577 → 850
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1170 → 1251
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:576 → 855
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:266 → 540
    DUF1908; Domain of unknown function (DUF1908)

  6. XM_047450142.1 → XP_047306098.1  microtubule-associated serine/threonine-protein kinase 2 isoform X26

  7. XM_047450096.1 → XP_047306052.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

  8. XM_047450145.1 → XP_047306101.1  microtubule-associated serine/threonine-protein kinase 2 isoform X27

  9. XM_047450111.1 → XP_047306067.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

  10. XM_047450149.1 → XP_047306105.1  microtubule-associated serine/threonine-protein kinase 2 isoform X28

  11. XM_047450150.1 → XP_047306106.1  microtubule-associated serine/threonine-protein kinase 2 isoform X29

  12. XM_047450153.1 → XP_047306109.1  microtubule-associated serine/threonine-protein kinase 2 isoform X30

  13. XM_047450105.1 → XP_047306061.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

  14. XM_047450121.1 → XP_047306077.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

  15. XM_047450123.1 → XP_047306079.1  microtubule-associated serine/threonine-protein kinase 2 isoform X12

  16. XM_047450129.1 → XP_047306085.1  microtubule-associated serine/threonine-protein kinase 2 isoform X13

  17. XM_011541064.3 → XP_011539366.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

    Conserved Domains (4) summary
    smart00220
    Location:531 → 804
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1124 → 1205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:530 → 809
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:213 → 494
    DUF1908; Domain of unknown function (DUF1908)

  18. XM_047450116.1 → XP_047306072.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

  19. XM_047450122.1 → XP_047306078.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

  20. XM_011541063.2 → XP_011539365.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

    Conserved Domains (4) summary
    smart00220
    Location:534 → 807
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1127 → 1208
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:533 → 812
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:216 → 497
    DUF1908; Domain of unknown function (DUF1908)

  21. XM_017000752.2 → XP_016856241.1  microtubule-associated serine/threonine-protein kinase 2 isoform X14

  22. XM_017000755.2 → XP_016856244.1  microtubule-associated serine/threonine-protein kinase 2 isoform X19

  23. XM_047450130.1 → XP_047306086.1  microtubule-associated serine/threonine-protein kinase 2 isoform X17

  24. XM_005270655.4 → XP_005270712.1  microtubule-associated serine/threonine-protein kinase 2 isoform X15

    Conserved Domains (4) summary
    smart00220
    Location:434 → 707
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1027 → 1108
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:433 → 712
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:116 → 397
    DUF1908; Domain of unknown function (DUF1908)

  25. XM_006710477.4 → XP_006710540.1  microtubule-associated serine/threonine-protein kinase 2 isoform X20

    UniProtKB/TrEMBL
    A0A669KBJ4
    Related
    ENSP00000501318.1, ENST00000674079.1
    Conserved Domains (4) summary
    smart00220
    Location:369 → 642
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:962 → 1043
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368 → 647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:51 → 332
    DUF1908; Domain of unknown function (DUF1908)

  26. XM_017000753.2 → XP_016856242.1  microtubule-associated serine/threonine-protein kinase 2 isoform X18

  27. XM_047450138.1 → XP_047306094.1  microtubule-associated serine/threonine-protein kinase 2 isoform X23

  28. XM_005270656.6 → XP_005270713.1  microtubule-associated serine/threonine-protein kinase 2 isoform X16

    Conserved Domains (4) summary
    smart00220
    Location:425 → 698
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:1018 → 1099
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:424 → 703
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:107 → 388
    DUF1908; Domain of unknown function (DUF1908)

  29. XM_011541067.3 → XP_011539369.1  microtubule-associated serine/threonine-protein kinase 2 isoform X21

    Conserved Domains (4) summary
    smart00220
    Location:357 → 630
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:950 → 1031
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:356 → 635
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:39 → 320
    DUF1908; Domain of unknown function (DUF1908)

  30. XM_011541068.2 → XP_011539370.1  microtubule-associated serine/threonine-protein kinase 2 isoform X22

    Conserved Domains (4) summary
    smart00220
    Location:350 → 623
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:943 → 1024
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:349 → 628
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:39 → 313
    DUF1908; Domain of unknown function (DUF1908)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    45680810..45913311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335330.1 → XP_054191305.1  microtubule-associated serine/threonine-protein kinase 2 isoform X1

  2. XM_054335352.1 → XP_054191327.1  microtubule-associated serine/threonine-protein kinase 2 isoform X24

  3. XM_054335331.1 → XP_054191306.1  microtubule-associated serine/threonine-protein kinase 2 isoform X2

  4. XM_054335353.1 → XP_054191328.1  microtubule-associated serine/threonine-protein kinase 2 isoform X25

  5. XM_054335332.1 → XP_054191307.1  microtubule-associated serine/threonine-protein kinase 2 isoform X3

  6. XM_054335354.1 → XP_054191329.1  microtubule-associated serine/threonine-protein kinase 2 isoform X26

  7. XM_054335333.1 → XP_054191308.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

  8. XM_054335355.1 → XP_054191330.1  microtubule-associated serine/threonine-protein kinase 2 isoform X27

  9. XM_054335337.1 → XP_054191312.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

  10. XM_054335356.1 → XP_054191331.1  microtubule-associated serine/threonine-protein kinase 2 isoform X28

  11. XM_054335357.1 → XP_054191332.1  microtubule-associated serine/threonine-protein kinase 2 isoform X29

  12. XM_054335358.1 → XP_054191333.1  microtubule-associated serine/threonine-protein kinase 2 isoform X30

  13. XM_054335336.1 → XP_054191311.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

  14. XM_054335339.1 → XP_054191314.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

  15. XM_054335341.1 → XP_054191316.1  microtubule-associated serine/threonine-protein kinase 2 isoform X12

  16. XM_054335342.1 → XP_054191317.1  microtubule-associated serine/threonine-protein kinase 2 isoform X13

  17. XM_054335335.1 → XP_054191310.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

  18. XM_054335338.1 → XP_054191313.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

  19. XM_054335340.1 → XP_054191315.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

  20. XM_054335334.1 → XP_054191309.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

  21. XM_054335343.1 → XP_054191318.1  microtubule-associated serine/threonine-protein kinase 2 isoform X14

  22. XM_054335348.1 → XP_054191323.1  microtubule-associated serine/threonine-protein kinase 2 isoform X19

  23. XM_054335344.1 → XP_054191319.1  microtubule-associated serine/threonine-protein kinase 2 isoform X15

  24. XM_054335346.1 → XP_054191321.1  microtubule-associated serine/threonine-protein kinase 2 isoform X17

  25. XM_054335349.1 → XP_054191324.1  microtubule-associated serine/threonine-protein kinase 2 isoform X20

  26. XM_054335347.1 → XP_054191322.1  microtubule-associated serine/threonine-protein kinase 2 isoform X18

  27. XM_054335345.1 → XP_054191320.1  microtubule-associated serine/threonine-protein kinase 2 isoform X16

  28. XM_054335350.1 → XP_054191325.1  microtubule-associated serine/threonine-protein kinase 2 isoform X21

  29. XM_054335351.1 → XP_054191326.1  microtubule-associated serine/threonine-protein kinase 2 isoform X22

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P0Q8.2 GenPept UniProtKB/Swiss-Prot:Q6P0Q8

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