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Atp10d ATPase, class V, type 10D [ Mus musculus (house mouse) ]

Gene ID: 231287, updated on 30-Mar-2024

Summary

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Official Symbol
Atp10dprovided by MGI
Official Full Name
ATPase, class V, type 10Dprovided by MGI
Primary source
MGI:MGI:2450125
See related
Ensembl:ENSMUSG00000046808 AllianceGenome:MGI:2450125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPVD; D5Buc24e; 9830145H18Rik
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be active in plasma membrane. Orthologous to human ATP10D (ATPase phospholipid transporting 10D (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Ubiquitous expression in spleen adult (RPKM 4.4), subcutaneous fat pad adult (RPKM 3.5) and 27 other tissues See more
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Genomic context

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Location:
5 C3.2; 5 38.44 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72360672..72456114)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72203329..72298771)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit beta 1 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13358 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72551776-72552076 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72559343-72559644 Neighboring gene STARR-positive B cell enhancer ABC_E670 Neighboring gene STARR-seq mESC enhancer starr_13361 Neighboring gene STARR-seq mESC enhancer starr_13362 Neighboring gene STARR-seq mESC enhancer starr_13363 Neighboring gene COMM domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E10323 Neighboring gene STARR-positive B cell enhancer ABC_E4761 Neighboring gene predicted gene, 25768 Neighboring gene corin, serine peptidase Neighboring gene STARR-seq mESC enhancer starr_13364 Neighboring gene synaptonemal complex central element protein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lipidomic and metabolic changes in the P4-type ATPase ATP10D deficient C57BL/6J wild type mice upon rescue of ATP10D function. Sigruener A, et al. PLoS One, 2017. PMID 28542499, Free PMC Article
  2. Characterization of a putative type IV aminophospholipid transporter P-type ATPase. Flamant S, et al. Mamm Genome, 2003 Jan. PMID 12532265
  3. Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3. Martynova E, et al. Open Biol, 2019 Dec. PMID 31847788, Free PMC Article
  4. A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5. Lengeling A, et al. Genome Res, 1999 Aug. PMID 10447508, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (2)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Clone Names

  • MGC37731

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables glycosylceramide flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic cation transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase VD
Names
P4-ATPase flippase complex alpha subunit ATP10D
probable phospholipid-transporting ATPase VD
putative type IV aminophospholipid transporting ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153389.3 → NP_700438.3  phospholipid-transporting ATPase VD

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the protein-coding transcript.
    Source sequence(s)
    AJ441079
    UniProtKB/Swiss-Prot
    Q8K2X1
    Conserved Domains (6) summary
    TIGR01652
    Location:124 → 1377
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:181 → 406
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:779 → 859
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:124 → 175
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:1132 → 1377
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:1101 → 1132
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. NR_003966.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the transcript expressed in the C57BL/6J mouse strain.
    Source sequence(s)
    AC084780, AC122915, AC129608
    Related
    ENSMUST00000126664.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    72360672..72456114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2X1.2 GenPept UniProtKB/Swiss-Prot:Q8K2X1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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