Semp2l2a SUMO/sentrin specific peptidase 2-like 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Semp2l2aprovided by MGI
Official Full Name: SUMO/sentrin specific peptidase 2-like 2Aprovided by MGI
Primary source: MGI:MGI:2667157
See related: Ensembl:ENSMUSG00000057116 AllianceGenome:MGI:2667157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Susp4
Summary: Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in protein destabilization; protein desumoylation; and regulation of protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of nuclear pore. Predicted to be active in nucleus. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8 A1.1; 8 6.38 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13885229..13888565, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13835229..13838565, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ultraviolet damage induced SUSP4 expression, leading to an increase in p53 levels in parallel with a decrease in Mdm2 levels.
Title: SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: SUMO-1 specific protease 4

Names: SUMO-1-specific protease 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.