NPIPB3 nuclear pore complex interacting protein family member B3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPIPB3provided by HGNC
Official Full Name: nuclear pore complex interacting protein family member B3provided by HGNC
Primary source: HGNC:HGNC:28989
See related: MIM:619984; AllianceGenome:HGNC:28989
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NPIP; NPIPB; NPIPB5; NPIPL3; KIAA0220L
Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Ubiquitous expression in skin (RPKM 36.9), bone marrow (RPKM 26.9) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 16p12.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (21402129..21425378, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (21337400..21360419, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (21413450..21436699, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The overexpression of NPIPB3 restored the interferon-beta responses in severe acute respiratory syndrome coronavirus open reading frame 6 (SARS-CoV ORF6) expressing cells, indicating that the interaction of SARS CoV ORF6 and NPIPB3 reduced Type I interferon antagonism by SARS-CoV ORF6.
Title: Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of nuclear pore complex interacting protein-like 3 (NPIPL3; KIAA0220L) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:485386

L18426 (e-PCR)
- UniSTS:34648

D1S1423 (e-PCR)
- UniSTS:149619

D16S3313 (e-PCR)
- UniSTS:57752

Cda0uf06 (e-PCR)
- UniSTS:85931

GDB:451833 (e-PCR)
- UniSTS:157380

D5S1597E (e-PCR)
- UniSTS:151019

Clone Names

FLJ17456, FLJ45371, FLJ54505, FLJ58661, FLJ79358, FLJ98670, KIAA0220, MGC70907, MGC105000

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	TAS Traceable Author Statement more info

General protein information

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Preferred Names: nuclear pore complex-interacting protein family member B3; LOW QUALITY PROTEIN: nuclear pore complex-interacting protein family member B3

Names: KIAA0220-like protein; nuclear pore complex-interacting protein B type; nuclear pore complex-interacting protein-like 3; protein pps22-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130464.3 → NP_569731.2 nuclear pore complex-interacting protein family member B3

Status: VALIDATED

Source sequence(s)

AK294452, BC036263, BQ950195, DC309942

Conserved Domains (3) summary

pfam06409
Location:41 → 302

NPIP; Nuclear pore complex interacting protein (NPIP)

pfam16496
Location:1032 → 1123

SWIRM-assoc_2; SWIRM-associated domain at the N-terminal

cl17068
Location:1 → 41

AFD_class_I; Adenylate forming domain, Class I superfamily