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Sh3tc1 SH3 domain and tetratricopeptide repeats 1 [ Mus musculus (house mouse) ]

Gene ID: 231147, updated on 5-Mar-2024

Summary

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Official Symbol
Sh3tc1provided by MGI
Official Full Name
SH3 domain and tetratricopeptide repeats 1provided by MGI
Primary source
MGI:MGI:2678949
See related
Ensembl:ENSMUSG00000036553 AllianceGenome:MGI:2678949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4631428G15
Summary
Is expressed in embryo mesenchyme and meninges. Orthologous to human SH3TC1 (SH3 domain and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 14.6), kidney adult (RPKM 12.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 18.6 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35854524..35897331, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35697180..35739987, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene HtrA serine peptidase 3 Neighboring gene STARR-seq mESC enhancer starr_12860 Neighboring gene predicted gene, 31888 Neighboring gene STARR-positive B cell enhancer ABC_E8820 Neighboring gene actin-binding LIM protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E8050 Neighboring gene actin filament associated protein 1 Neighboring gene H2A histone family, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC67153

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
SH3 domain and tetratricopeptide repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359895.1 → NP_001346824.1  SH3 domain and tetratricopeptide repeat-containing protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC122871, AK167283
    Consensus CDS
    CCDS19234.2
    UniProtKB/TrEMBL
    G3X9F6, Q3TXV8, Q3UDI4
    Related
    ENSMUSP00000144175.2, ENSMUST00000201511.2
    Conserved Domains (3) summary
    cd11885
    Location:313 → 367
    SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
    sd00006
    Location:1163 → 1190
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1166 → 1231
    TPR_12; Tetratricopeptide repeat

  2. NM_194344.2 → NP_919325.2  SH3 domain and tetratricopeptide repeat-containing protein 1

    See identical proteins and their annotated locations for NP_919325.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK150064, AK159089, BY201660, BY513538
    Consensus CDS
    CCDS19234.2
    UniProtKB/TrEMBL
    G3X9F6, Q3TXV8, Q3UDI4
    Related
    ENSMUSP00000070610.8, ENSMUST00000070203.14
    Conserved Domains (3) summary
    cd11885
    Location:313 → 367
    SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
    sd00006
    Location:1163 → 1190
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1166 → 1231
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    35854524..35897331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503904.4 → XP_006503967.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006503967.1

    UniProtKB/TrEMBL
    G3X9F6, Q3TXV8, Q3UDI4
    Related
    ENSMUSP00000115376.2, ENSMUST00000127825.8
    Conserved Domains (3) summary
    cd11885
    Location:313 → 367
    SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
    sd00006
    Location:1163 → 1190
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1166 → 1231
    TPR_12; Tetratricopeptide repeat

  2. XM_036165020.1 → XP_036020913.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3TXV8, Q3UDI4
    Conserved Domains (3) summary
    cd11885
    Location:288 → 342
    SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
    sd00006
    Location:1138 → 1165
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:1141 → 1206
    TPR_12; Tetratricopeptide repeat

  3. XM_036165021.1 → XP_036020914.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q3TXV8, Q3UDI4
    Conserved Domains (3) summary
    cd11885
    Location:119 → 173
    SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
    sd00006
    Location:969 → 996
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:972 → 1037
    TPR_12; Tetratricopeptide repeat

  4. XM_006503905.3 → XP_006503968.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    Q6KAR4
    Conserved Domains (2) summary
    sd00006
    Location:813 → 840
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:816 → 881
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein Strain
Heading Accession and Version

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