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Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 [ Mus musculus (house mouse) ]

Gene ID: 231050, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt11provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 11provided by MGI
Primary source
MGI:MGI:2444392
See related
Ensembl:ENSMUSG00000038072 AllianceGenome:MGI:2444392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430075I06Rik; E430002F06Rik
Summary
Predicted to enable Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine and regulation of Notch signaling pathway. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 102.6), CNS E18 (RPKM 9.5) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Galnt11 in Genome Data Viewer
Location:
5 A3- B1; 5 12.35 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25427732..25470916)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (25222872..25265918)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33836 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 Neighboring gene STARR-seq mESC enhancer starr_12661 Neighboring gene lysine (K)-specific methyltransferase 2C Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 3 Neighboring gene sperm associated antigen 7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic variation regulates opioid-induced respiratory depression in mice. Bubier JA, et al. Sci Rep, 2020 Sep 11. PMID 32917924, Free PMC Article
  2. The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. Fritz TA, et al. Proc Natl Acad Sci U S A, 2004 Oct 26. PMID 15486088, Free PMC Article
  3. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Young WW Jr, et al. Glycobiology, 2003 Jul. PMID 12651884
  4. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
  5. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic variation regulates opioid-induced respiratory depression in mice.
    Title: Genetic variation regulates opioid-induced respiratory depression in mice.
  2. Megalin in Galnt11-deficient mice displays reduced ligand binding and undergoes age-related loss within the kidney.
    Title: Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.
  3. real-time polymerase chain reaction using the Taqman method to determine the expression of ppGaNTase isoforms in mouse tissues. In contrast to the general pattern, testis, sublingual gland, and colon exhibited distinctive profiles of isoform expression
    Title: Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family.
  4. homology models of several ppGaNTase isoforms predict dramatically different surface chemistries consistent with isoform-selective acceptor substrate recognition
    Title: The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Notch binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 11
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
galNAc-T11
polypeptide GalNAc transferase 11
pp-GaNTase 11
protein-UDP acetylgalactosaminyltransferase 11
NP_001346819.1
NP_659157.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359890.1 → NP_001346819.1  polypeptide N-acetylgalactosaminyltransferase 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform.
    Source sequence(s)
    AC127319, AK161524
    Consensus CDS
    CCDS19133.1
    UniProtKB/Swiss-Prot
    Q3TT83, Q8BU26, Q8K032, Q921L8
    Related
    ENSMUSP00000110602.2, ENSMUST00000114952.8
    Conserved Domains (2) summary
    cd02510
    Location:154 → 452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483 → 604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_144908.4 → NP_659157.1  polypeptide N-acetylgalactosaminyltransferase 11

    See identical proteins and their annotated locations for NP_659157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC127319, Y12435
    Consensus CDS
    CCDS19133.1
    UniProtKB/Swiss-Prot
    Q3TT83, Q8BU26, Q8K032, Q921L8
    Related
    ENSMUSP00000036240.8, ENSMUST00000045737.14
    Conserved Domains (2) summary
    cd02510
    Location:154 → 452
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:483 → 604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    25427732..25470916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003955624.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921L8.1 GenPept UniProtKB/Swiss-Prot:Q921L8

Gene LinkOut

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