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Arhgef16 Rho guanine nucleotide exchange factor 16 [ Mus musculus (house mouse) ]

Gene ID: 230972, updated on 5-Mar-2024

Summary

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Official Symbol
Arhgef16provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 16provided by MGI
Primary source
MGI:MGI:2446219
See related
Ensembl:ENSMUSG00000029032 AllianceGenome:MGI:2446219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity; cell chemotaxis; and positive regulation of protein localization to plasma membrane. Predicted to be located in cytoplasm. Is expressed in several structures, including branchial arch; chordamesoderm; embryo ectoderm; extraembryonic component; and otocyst. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 48.9), duodenum adult (RPKM 48.3) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 83.96 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154362926..154384535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154278469..154300107, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene STARR-seq mESC enhancer starr_12229 Neighboring gene transformation related protein 63 regulated 1 like Neighboring gene multiple EGF-like-domains 6 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene predicted gene, 52687 Neighboring gene STARR-seq mESC enhancer starr_12232 Neighboring gene PR domain containing 16 Neighboring gene VISTA enhancer mm1087 Neighboring gene STARR-seq mESC enhancer starr_12235 Neighboring gene predicted gene, 52688 Neighboring gene predicted gene 13133

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation. Lee J, et al. Biochim Biophys Acta, 2014 Nov. PMID 25063526
  2. Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Sousa-Nunes R, et al. Genome Res, 2003 Dec. PMID 14613977, Free PMC Article
  3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 16
Names
Neuroblastoma
Rho guanine nucleotide exchange factor (GEF) 16
ephexin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112744.1 → NP_001106215.1  rho guanine nucleotide exchange factor 16

    See identical proteins and their annotated locations for NP_001106215.1

    Status: PROVISIONAL

    Source sequence(s)
    AK042195, AK153708
    Consensus CDS
    CCDS51399.1
    UniProtKB/Swiss-Prot
    B1ASH6, Q3U5C8, Q501M8, Q8VCE8
    Related
    ENSMUSP00000030898.6, ENSMUST00000030898.12
    Conserved Domains (3) summary
    cd11938
    Location:637 → 688
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:493 → 626
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:292 → 470
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    154362926..154384535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250242.4 → XP_011248544.1  rho guanine nucleotide exchange factor 16 isoform X2

    See identical proteins and their annotated locations for XP_011248544.1

    UniProtKB/Swiss-Prot
    B1ASH6, Q3U5C8, Q501M8, Q8VCE8
    Conserved Domains (3) summary
    cd11938
    Location:637 → 688
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:493 → 626
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:292 → 470
    RhoGEF; RhoGEF domain

  2. XM_006538829.5 → XP_006538892.1  rho guanine nucleotide exchange factor 16 isoform X2

    See identical proteins and their annotated locations for XP_006538892.1

    UniProtKB/Swiss-Prot
    B1ASH6, Q3U5C8, Q501M8, Q8VCE8
    Conserved Domains (3) summary
    cd11938
    Location:637 → 688
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:493 → 626
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:292 → 470
    RhoGEF; RhoGEF domain

  3. XM_011250241.4 → XP_011248543.1  rho guanine nucleotide exchange factor 16 isoform X1

    Conserved Domains (3) summary
    cd11938
    Location:645 → 696
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:501 → 634
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:300 → 478
    RhoGEF; RhoGEF domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U5C8.3 GenPept UniProtKB/Swiss-Prot:Q3U5C8

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