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Megf6 multiple EGF-like-domains 6 [ Mus musculus (house mouse) ]

Gene ID: 230971, updated on 5-Mar-2024

Summary

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Official Symbol
Megf6provided by MGI
Official Full Name
multiple EGF-like-domains 6provided by MGI
Primary source
MGI:MGI:1919351
See related
Ensembl:ENSMUSG00000057751 AllianceGenome:MGI:1919351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Egfl3; 2600001P17Rik
Summary
Predicted to enable calcium ion binding activity. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; embryo mesenchyme; head bone; intraembryonic coelom; and pharyngo-tympanic tube. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 18.7), limb E14.5 (RPKM 18.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Megf6 in Genome Data Viewer
Location:
4 E2; 4 83.89 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154255156..154360178)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154170704..154275721)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4737 Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene STARR-seq mESC enhancer starr_12229 Neighboring gene WD repeat containing, antisense to Trp73 Neighboring gene transformation related protein 63 regulated 1 like Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Rho guanine nucleotide exchange factor 16 Neighboring gene predicted gene, 52687 Neighboring gene STARR-seq mESC enhancer starr_12232 Neighboring gene PR domain containing 16 Neighboring gene VISTA enhancer mm1087 Neighboring gene STARR-seq mESC enhancer starr_12235 Neighboring gene predicted gene, 52688

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation and characterization of Megf6 null and Cre knock-in alleles. Wang Y, et al. Genesis, 2019 Feb. PMID 30381865
  2. MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFβ/SMAD Signaling Pathway in Colorectal Cancer Metastasis. Hu H, et al. Cell Physiol Biochem, 2018. PMID 29719292
  3. Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly. Penner AS, et al. J Biol Chem, 2002 Sep 20. PMID 12122015
  4. Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Naba A, et al. Sci Rep, 2017 Jan 10. PMID 28071719, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEGF6 prevents sepsis-induced acute lung injury in mice.
    Title: MEGF6 prevents sepsis-induced acute lung injury in mice.
  2. MEGF6 promoted Colorectal Cancer Metastasis metastasis in vitro and in vivo.
    Title: MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFβ/SMAD Signaling Pathway in Colorectal Cancer Metastasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC49785

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multiple epidermal growth factor-like domains protein 6
Names
EGF-like protein 3
EGF-like-domain, multiple 3
epidermal growth factor-like protein 3
multiple EGF-like domains protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162977.1 → NP_001156449.1  multiple epidermal growth factor-like domains protein 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627123
    Consensus CDS
    CCDS51398.1
    UniProtKB/TrEMBL
    A0A0A0MQ83
    Related
    ENSMUSP00000030897.9, ENSMUST00000030897.15
    Conserved Domains (3) summary
    pfam07546
    Location:42 → 111
    EMI; EMI domain
    pfam14670
    Location:337 → 372
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:153 → 201
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    154255156..154360178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250240.2 → XP_011248542.1  multiple epidermal growth factor-like domains protein 6 isoform X2

    Conserved Domains (3) summary
    pfam07546
    Location:42 → 111
    EMI; EMI domain
    pfam14670
    Location:337 → 372
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:153 → 201
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_006538826.3 → XP_006538889.1  multiple epidermal growth factor-like domains protein 6 isoform X1

    Conserved Domains (3) summary
    pfam07546
    Location:42 → 111
    EMI; EMI domain
    pfam14670
    Location:296 → 331
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:242 → 283
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_006538827.2 → XP_006538890.1  multiple epidermal growth factor-like domains protein 6 isoform X3

    Related
    ENSMUSP00000121641.2, ENSMUST00000152159.8
    Conserved Domains (2) summary
    pfam14670
    Location:229 → 264
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:175 → 216
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172273.1: Suppressed sequence

    Description
    NM_172273.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80V70.3 GenPept UniProtKB/Swiss-Prot:Q80V70

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