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Ajap1 adherens junction associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 230959, updated on 5-Mar-2024

Summary

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Official Symbol
Ajap1provided by MGI
Official Full Name
adherens junction associated protein 1provided by MGI
Primary source
MGI:MGI:2685419
See related
Ensembl:ENSMUSG00000039546 AllianceGenome:MGI:2685419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm573
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Predicted to act upstream of or within cell adhesion. Predicted to be located in basolateral plasma membrane and cell surface. Predicted to be active in adherens junction; cell-cell contact zone; and cytoplasmic side of plasma membrane. Predicted to be spanning component of plasma membrane. Is expressed in several structures, including adrenal gland; brain; eye; genitourinary system; and spinal cord. Orthologous to human AJAP1 (adherens junctions associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 5.3), cortex adult (RPKM 4.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 83.71 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (153457678..153568313, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (153373221..153483795, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12211 Neighboring gene predicted gene, 30911 Neighboring gene STARR-seq mESC enhancer starr_12212 Neighboring gene STARR-seq mESC enhancer starr_12213 Neighboring gene predicted gene, 31055 Neighboring gene STARR-seq mESC enhancer starr_12214 Neighboring gene STARR-seq mESC enhancer starr_12215 Neighboring gene STARR-seq mESC enhancer starr_12216 Neighboring gene predicted gene, 42358 Neighboring gene predicted gene, 42359

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AJAP1 affects behavioral changes and GABA(B)R1 level in epileptic mice. Zhang M, et al. Biochem Biophys Res Commun, 2020 Apr 16. PMID 32067740
  2. MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression. Qu W, et al. J Cell Mol Med, 2019 Feb. PMID 30597727, Free PMC Article
  3. Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. Schreiner A, et al. Mol Biol Cell, 2007 Apr. PMID 17267690, Free PMC Article
  4. Complex formation of APP with GABA(B) receptors links axonal trafficking to amyloidogenic processing. Dinamarca MC, et al. Nat Commun, 2019 Mar 22. PMID 30902970, Free PMC Article
  5. Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile. Klemmt PA, et al. Biol Open, 2016 Nov 15. PMID 27870635, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AJAP1 affects behavioral changes and GABABR1 level in epileptic mice.
    Title: AJAP1 affects behavioral changes and GABA(B)R1 level in epileptic mice.
  2. The findings suggested that miR-552 promotes hepatocellular carcinoma oncogenesis and progression by inhibiting AJAP1 expression.
    Title: MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of polarized epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell contact zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adherens junction-associated protein 1
Names
likely ortholog of H. sapiens transmembrane protein SHREW1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099299.1 → NP_001092769.1  adherens junction-associated protein 1 precursor

    See identical proteins and their annotated locations for NP_001092769.1

    Status: VALIDATED

    Source sequence(s)
    AL805910, AL954390
    Consensus CDS
    CCDS38987.1
    UniProtKB/Swiss-Prot
    A2ALI5, B2RVK0
    Related
    ENSMUSP00000101271.2, ENSMUST00000105646.3
    Conserved Domains (1) summary
    pfam15298
    Location:181 → 389
    AJAP1_PANP_C; AJAP1/PANP C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    153457678..153568313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538824.5 → XP_006538887.1  adherens junction-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15298
    Location:178 → 386
    AJAP1_PANP_C; AJAP1/PANP C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ALI5.1 GenPept UniProtKB/Swiss-Prot:A2ALI5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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