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Tmem201 transmembrane protein 201 [ Mus musculus (house mouse) ]

Gene ID: 230917, updated on 3-Apr-2024

Summary

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Official Symbol
Tmem201provided by MGI
Official Full Name
transmembrane protein 201provided by MGI
Primary source
MGI:MGI:1196277
See related
Ensembl:ENSMUSG00000044700 AllianceGenome:MGI:1196277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Net5; Samp1; D4Ertd429e
Summary
Enables actin filament binding activity and lamin binding activity. Acts upstream of or within fibroblast migration and nuclear migration. Located in nuclear membrane. Orthologous to human TMEM201 (transmembrane protein 201). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 31.0), adrenal adult (RPKM 24.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 80.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149799832..149822501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149715375..149738072, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calsyntenin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149032165-149032348 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene microRNA 7023 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149063846-149064146 Neighboring gene STARR-positive B cell enhancer ABC_E9249 Neighboring gene STARR-positive B cell enhancer ABC_E2730 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149084694-149084994 Neighboring gene solute carrier family 25, member 33 Neighboring gene STARR-seq mESC enhancer starr_12124 Neighboring gene predicted gene 13073

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice. Shimizu A, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28893537
  2. A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. Menghini P, et al. PLoS One, 2017. PMID 28301579, Free PMC Article
  3. [Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice]. Khudoerkov RM, et al. Arkh Patol, 2014 Mar-Apr. PMID 25051721
  4. Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1). Aoyama Y, et al. Brain Res, 2013 Jun 17. PMID 23583482
  5. Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness. Fan J, et al. Metabolism, 2022 Sep. PMID 35792174, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.
    Title: Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.
  2. Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
    Title: Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
  3. These observations suggest that tumor suppression was caused not by mtDNA with polymorphic mutations or infection of cytozoic bacteria but by hypothetical heritable cytoplasmic elements other than mtDNA from SAMP1 mice.
    Title: Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.
  4. data demonstrate a heightened susceptibility to colonic inflammation and tumorigenesis in AOM/DSS-treated SAMP mice with CD-like ileitis
    Title: A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis.
  5. In the SAMP1 mice versus the SAMR1 ones, the glial index rose by 36% in layer III and by 24% in layer V. During simulation of physiological aging, the sizes of neuronal bodies were shown to be virtually unchanged in the cerebral cortex
    Title: [Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice].
  6. At 2- and 4-months old, SAMP1 mice show motor-coordination dysfunction.
    Title: Impaired motor function in senescence-accelerated mouse prone 1 (SAMP1).
  7. findings show that the nuclear envelope protein Samp1 is involved in nuclear movement during fibroblast polarization and migration
    Title: Samp1 is a component of TAN lines and is required for nuclear movement.
  8. Nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Samp1 is part of the TAN lines complex that contain nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C.
    Title: Samp1 is a component of TAN lines and is required for nuclear movement.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • RP23-383I7.1

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with cortical endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 201
Names
spindle-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284270.2 → NP_001271199.1  transmembrane protein 201 isoform c

    See identical proteins and their annotated locations for NP_001271199.1

    Status: VALIDATED

    Source sequence(s)
    AL626808
    Consensus CDS
    CCDS71523.1
    UniProtKB/Swiss-Prot
    A2A8U2, Q3U5F3, Q6GQS9, Q8BNY3
    Related
    ENSMUSP00000101312.3, ENSMUST00000105687.9
    Conserved Domains (2) summary
    pfam09779
    Location:47 → 169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192 → 379
    DUF2448; Protein of unknown function C-terminus (DUF2448)

  2. NM_001284273.2 → NP_001271202.1  transmembrane protein 201 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL626808
    UniProtKB/TrEMBL
    Q3TXY3
    Conserved Domains (2) summary
    pfam09779
    Location:3 → 125
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:148 → 343
    DUF2448; Protein of unknown function C-terminus (DUF2448)

  3. NM_001426158.1 → NP_001413087.1  transmembrane protein 201 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL626808

  4. NM_001426159.1 → NP_001413088.1  transmembrane protein 201 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL626808

  5. NM_001426160.1 → NP_001413089.1  transmembrane protein 201 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL626808

  6. NM_001426165.1 → NP_001413094.1  transmembrane protein 201 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL626808

  7. NM_001426168.1 → NP_001413097.1  transmembrane protein 201 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL626808

  8. NM_001426169.1 → NP_001413098.1  transmembrane protein 201 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL626808

  9. NM_177672.5 → NP_808340.2  transmembrane protein 201 isoform b

    See identical proteins and their annotated locations for NP_808340.2

    Status: VALIDATED

    Source sequence(s)
    AL626808
    Consensus CDS
    CCDS18965.1
    UniProtKB/TrEMBL
    Q8C397
    Related
    ENSMUSP00000099497.2, ENSMUST00000103208.2
    Conserved Domains (2) summary
    pfam09779
    Location:47 → 169
    Ima1_N; Ima1 N-terminal domain
    pfam10476
    Location:192 → 387
    DUF2448; Protein of unknown function C-terminus (DUF2448)

RNA

  1. NR_189667.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL626808

  2. NR_189668.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL626808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149799832..149822501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003954938.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025106.1: Suppressed sequence

    Description
    NM_001025106.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A8U2.1 GenPept UniProtKB/Swiss-Prot:A2A8U2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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